PMID- 34126421 OWN - NLM STAT- MEDLINE DCOM- 20210805 LR - 20210805 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 140 DP - 2021 Aug TI - Abnormality of subcortical volume and resting functional connectivity in adolescents with early-onset and prodromal schizophrenia. PG - 282-288 LID - S0022-3956(21)00322-8 [pii] LID - 10.1016/j.jpsychires.2021.05.052 [doi] AB - OBJECTIVE: Studies have found that there may be qualitative changes in brain structure and function in adolescents with early-onset schizophrenia (EOS) and prodromal schizophrenia (PDS). However, the abnormal brain structure and function of adolescents with EOS and PDS have received little attention, and their underlying neural mechanisms are still unknown. METHODS: In this study, structural and resting-state functional magnetic resonance imaging (fMRI) were used to compare the subcortical volume and functional connectivity (FC) among EOS, PDS, and a control group. The Positive and Negative Symptom Scale (PNASS) questionnaire was used for clinical evaluation. Structural MRI was used to calculate cortical-based morphological volume and subcortical volume, and resting-state fMRI was used to analyze seed-based FC. RESULTS: Structural MRI analyses showed that the gray matter volume of the hippocampus in EOS was significantly smaller than that in the control group, and the gray matter volume of the hippocampus, amygdala, and caudate nucleus in PDS was significantly smaller than that in the control group. Additionally, correlation analysis showed that the gray matter volume of the hippocampus was significantly negatively correlated with the negative symptom score of PANSS in EOS. When the hippocampus was used as the seed, fMRI analysis found that the FC between the hippocampus and the posterior cingulate gyrus and precuneus in EOS was significantly weaker than that in the control group. CONCLUSION: Our results indicate that the brain structure and function are abnormal in EOS and PDS, with abnormalities mainly concentrated in the limbic system, including the hippocampus, amygdala, caudate nucleus, cingulate gyrus, and precuneus. These findings provide a new direction for early intervention and improvement of the prognosis of schizophrenic patients. CI - Copyright (c) 2021 Elsevier Ltd. All rights reserved. FAU - Wen, Dan AU - Wen D AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China. FAU - Wang, Junjie AU - Wang J AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China. FAU - Yao, Guanqun AU - Yao G AD - School of Clinical Medicine, Tsinghua University, Beijing, China; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Beijing, China. FAU - Liu, Sha AU - Liu S AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China. FAU - Li, Xinrong AU - Li X AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China. FAU - Li, Jing AU - Li J AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China. FAU - Li, Hong AU - Li H AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China. Electronic address: lihong2012412@163.com. FAU - Xu, Yong AU - Xu Y AD - Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Department of Mental Health, Shanxi Medical University, Taiyuan, China. Electronic address: xuyong@sxmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210604 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Adolescent MH - Brain/diagnostic imaging MH - Brain Mapping MH - Humans MH - Magnetic Resonance Imaging MH - Rest MH - *Schizophrenia/diagnostic imaging OTO - NOTNLM OT - Early-onset schizophrenia (EOS) OT - Functional connectivity (FC) OT - Functional magnetic resonance imaging (fMRI) OT - Hippocampus OT - Prodromal schizophrenia (PDS) OT - Voxel-based morphometric (VBM) EDAT- 2021/06/15 06:00 MHDA- 2021/08/06 06:00 CRDT- 2021/06/14 20:23 PHST- 2020/08/04 00:00 [received] PHST- 2021/05/05 00:00 [revised] PHST- 2021/05/21 00:00 [accepted] PHST- 2021/06/15 06:00 [pubmed] PHST- 2021/08/06 06:00 [medline] PHST- 2021/06/14 20:23 [entrez] AID - S0022-3956(21)00322-8 [pii] AID - 10.1016/j.jpsychires.2021.05.052 [doi] PST - ppublish SO - J Psychiatr Res. 2021 Aug;140:282-288. doi: 10.1016/j.jpsychires.2021.05.052. Epub 2021 Jun 4.