PMID- 34128902
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 24
DP  - 2021 Jun 18
TI  - Correlation analysis of expression of CC and CXC chemokines in children with 
      autism spectrum disorder.
PG  - e26391
LID - 10.1097/MD.0000000000026391 [doi]
LID - e26391
AB  - To investigate the relationship between the expression of CC and CXC chemokines 
      and autism spectrum disorder (ASD).A total of 62 children with ASD (ASD group) 
      and 60 gender- and age-matched normal children (control group) admitted to our 
      hospital from January 2019 to January 2020 were included in the study. Monocyte 
      chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha), 
      macrophage inflammatory protein-1beta (MIP-1beta), regulated upon activation, normal 
      T-cell expressed and secreted (RANTES), interleukin-8 (IL-8), monokine induced by 
      interferon (IFN)-gamma (MIG), and purified human interferon-gamma-induced protein-10 
      (IP-10) were detected in the ASD group. The correlation between the above indexes 
      and the severity of the ASD group was analyzed.Significantly increased MCP-1 
      levels (P < .01) along with the markedly decreased MIP-1alpha and MIP-1beta levels 
      (P < .01) were detected in the venous blood of the ASD group compared with the 
      control group. In addition, they exhibited no significant difference (yet a 
      downward trend) in the level of RANTES (P > .05). Children in the ASD group 
      showed significantly decreased IP-10 levels (P < .01); however, they had no 
      noticeable change (yet a decreasing trend) in the levels of IL-8 and MIG 
      (P > .05). MCP-1 level was positively related to the Module 1 scores of Autism 
      Diagnostic Observation Schedule-second edition (ADOS-2), whereas the levels of 
      Childhood Autism Rating Scale MIP-1alpha, MIP-1beta, IL-8, IP-10, and MIG were 
      negatively correlated with the ADOS-2 Module 1 scores (P < .01). However, no 
      significant correlation was found between RANTES and the ADOS-2 Module 1 scores 
      (P > .05).The levels of CC chemokines (MCP-1, MIP-1alpha, MIP-1beta, and RANTES) and CXC 
      chemokines (IL-8, IP-10, and MIG) are positively correlated with the pathogenesis 
      of ASD. Inflammation is an important contributing factor to ASD.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Peng, Guangyang
AU  - Peng G
AD  - Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital.
FAU - Peng, Xiaofei
AU  - Peng X
AD  - Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital.
FAU - Tong, Tingting
AU  - Tong T
AD  - Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital.
FAU - Zhang, Xiuyun
AU  - Zhang X
AD  - Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital.
FAU - Xu, Min
AU  - Xu M
AD  - Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital.
FAU - Peng, Xiaofang
AU  - Peng X
AD  - Huanggang Central Hospital, Huanggang, Hubei 438000, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemokines, CXC)
SB  - IM
MH  - Autism Spectrum Disorder/*immunology
MH  - Chemokines, CC/*blood
MH  - Chemokines, CXC/*blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Severity of Illness Index
PMC - PMC8213293
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2021/06/16 06:00
MHDA- 2021/06/25 06:00
PMCR- 2021/06/18
CRDT- 2021/06/15 13:31
PHST- 2020/11/04 00:00 [received]
PHST- 2021/05/26 00:00 [accepted]
PHST- 2021/06/15 13:31 [entrez]
PHST- 2021/06/16 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2021/06/18 00:00 [pmc-release]
AID - 00005792-202106180-00061 [pii]
AID - MD-D-20-10907 [pii]
AID - 10.1097/MD.0000000000026391 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Jun 18;100(24):e26391. doi: 
      10.1097/MD.0000000000026391.