PMID- 34129109
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20220224
IS  - 1435-2451 (Electronic)
IS  - 1435-2443 (Print)
IS  - 1435-2443 (Linking)
VI  - 406
IP  - 7
DP  - 2021 Nov
TI  - Planned surgery in the COVID-19 pandemic: a prospective cohort study from 
      Nottingham.
PG  - 2469-2477
LID - 10.1007/s00423-021-02207-8 [doi]
AB  - PURPOSE: Globally planned surgical procedures have been deferred during the 
      current COVID-19 pandemic. The study aimed to report the outcomes of planned 
      urgent and cancer cases during the current pandemic using a multi-disciplinary 
      prioritisation group. METHODS: A prospective cohort study of patients having 
      urgent or cancer surgery at a NHS Trust from 1st March to 30th April 2020 who had 
      been prioritised by a multi-disciplinary COVID Surgery group. Rates of 
      post-operative PCR positive and suspected COVID-19 infections within 30 days, 
      30-day mortality and any death related to COVID-19 are reported. RESULTS: Overall 
      597 patients underwent surgery with a median age of 65 years (interquartile range 
      (IQR) 54-74 years). Of these, 86.1% (514/597) had a current cancer diagnosis. 
      During the period, 60.8% (363/597) of patients had surgery at the NHS Trust 
      whilst 39.2% (234/597) had surgery at Independent Sector hospitals. The incidence 
      of COVID-19 in the East Midlands was 193.7 per 100,000 population during the 
      study period. In the 30 days following surgery, 1.3% (8/597) of patients tested 
      positive for COVID-19 with all cases at the NHS site. Overall 30-day mortality 
      was 0.7% (4/597). Following a PCR positive COVID-19 diagnosis, mortality was 
      25.0% (2/8). Including both PCR positive and suspected cases, 3.0% (18/597) 
      developed COVID-19 infection with 1.3% at the independent site compared to 4.1% 
      at the NHS Trust (p=0.047). CONCLUSIONS: Rates of COVID-19 infection in the 
      post-operative period were low especially in the Independent Sector site. 
      Mortality following a post-operative diagnosis of COVID-19 was high.
CI  - (c) 2021. The Author(s).
FAU - Catton, J
AU  - Catton J
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK.
FAU - Banerjea, A
AU  - Banerjea A
AUID- ORCID: 0000-0002-3094-2870
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK.
FAU - Gregory, S
AU  - Gregory S
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK.
FAU - Hall, C
AU  - Hall C
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK.
FAU - Crooks, C J
AU  - Crooks CJ
AUID- ORCID: 0000-0002-6794-6621
AD  - National Institute for Health Research (NIHR) Nottingham Biomedical Research 
      Centre (BRC), Nottingham University Hospitals NHS Trust and the University of 
      Nottingham, School of Medicine, E Floor West Block, Queen's Medical Centre 
      Campus, Nottingham, NG7 2UH, UK.
FAU - Lewis-Lloyd, C A
AU  - Lewis-Lloyd CA
AUID- ORCID: 0000-0001-9996-3699
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK. mzxcl1@exmail.nottingham.ac.uk.
AD  - National Institute for Health Research (NIHR) Nottingham Biomedical Research 
      Centre (BRC), Nottingham University Hospitals NHS Trust and the University of 
      Nottingham, School of Medicine, E Floor West Block, Queen's Medical Centre 
      Campus, Nottingham, NG7 2UH, UK. mzxcl1@exmail.nottingham.ac.uk.
FAU - Marshall, A
AU  - Marshall A
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK.
FAU - Humes, D J
AU  - Humes DJ
AUID- ORCID: 0000-0002-7071-4098
AD  - Division of Surgery, Nottingham University Hospitals NHS Trust, Nottingham, NG7 
      2UH, UK.
AD  - National Institute for Health Research (NIHR) Nottingham Biomedical Research 
      Centre (BRC), Nottingham University Hospitals NHS Trust and the University of 
      Nottingham, School of Medicine, E Floor West Block, Queen's Medical Centre 
      Campus, Nottingham, NG7 2UH, UK.
LA  - eng
PT  - Journal Article
DEP - 20210615
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
SB  - IM
MH  - Aged
MH  - *COVID-19
MH  - COVID-19 Testing
MH  - Humans
MH  - Middle Aged
MH  - *Pandemics
MH  - Prospective Studies
MH  - SARS-CoV-2
PMC - PMC8204733
OTO - NOTNLM
OT  - COVID-19
OT  - HPB
OT  - Lower GI
OT  - Mortality
OT  - Upper GI
COIS- The authors declare no competing interests.
EDAT- 2021/06/16 06:00
MHDA- 2021/11/12 06:00
PMCR- 2021/06/15
CRDT- 2021/06/15 13:37
PHST- 2020/12/30 00:00 [received]
PHST- 2021/05/16 00:00 [accepted]
PHST- 2021/06/16 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/06/15 13:37 [entrez]
PHST- 2021/06/15 00:00 [pmc-release]
AID - 10.1007/s00423-021-02207-8 [pii]
AID - 2207 [pii]
AID - 10.1007/s00423-021-02207-8 [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 2021 Nov;406(7):2469-2477. doi: 
      10.1007/s00423-021-02207-8. Epub 2021 Jun 15.