PMID- 34129890
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 197
DP  - 2021 Jul
TI  - Caloric restriction enhances vascular tone of cerebral and mesenteric resistance 
      arteries in aged rats.
PG  - 111520
LID - S0047-6374(21)00092-0 [pii]
LID - 10.1016/j.mad.2021.111520 [doi]
AB  - Vascular changes of tone and biomechanical properties induced by ageing increase 
      the risk for cardiovascular diseases. Caloric restriction (CR) has been shown to 
      protect against cardiovascular diseases and improve endothelial dysfunction in 
      cerebral resistance arteries. We hypothesise that CR will enhance vascular tone 
      and structural properties of cerebral resistance arteries and exert comparable 
      beneficial effects on the systemic vasculature of aged rat model. 
      Eighteen-month-old male Sprague-Dawley rats were feed either ad libitum or 
      restricted to 60 % of calorie consumption up to 24 months of age, when body 
      weight (BW) measurements were taken and functional and structural properties of 
      resistance arteries were assessed using a pressure myograph. In cerebral 
      arteries, CR increased myogenic tone (p < 0.001) and distensibility (p < 0.01) in 
      response to intraluminal pressure and concentration-dependent constriction to KCl 
      (p < 0.001). In mesenteric arteries constriction in response to KCl was increased 
      (p < 0.0001) and wall thickness reduced (p < 0.01) in CR rats. BW was reduced (p 
      < 0.0001) in FR rats. Our findings demonstrate that CR improves vascular tone of 
      resistance arteries regardless the type of stimulus and independently of the 
      vascular bed. CR may be a beneficial dietary approach to prevent age-related 
      vascular diseases.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Tropea, Teresa
AU  - Tropea T
AD  - Maternal and Fetal Health Research Centre, Division of Developmental Biology and 
      Medicine, Faculty of Biology, Medicine and Health, University of Manchester, 
      Manchester, United Kingdom; Manchester Academic Health Science Centre, Manchester 
      University NHS Foundation Trust, St. Mary's Hospital, Manchester, United Kingdom; 
      Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, 
      Rende, Italy.
FAU - Mandala, Maurizio
AU  - Mandala M
AD  - Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, 
      Rende, Italy; Department of Obstetrics, Gynecology and Reproductive Science, 
      University of Vermont, Burlington, VT, 05405, USA. Electronic address: 
      m.mandala@unical.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210612
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Cerebral Arteries/*physiopathology
MH  - Male
MH  - Mesenteric Arteries/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Vascular Resistance
OTO - NOTNLM
OT  - Ageing
OT  - Endothelial cell
OT  - Smooth muscle cells
OT  - Vascular structure
EDAT- 2021/06/16 06:00
MHDA- 2022/01/18 06:00
CRDT- 2021/06/15 20:12
PHST- 2021/03/29 00:00 [received]
PHST- 2021/06/09 00:00 [revised]
PHST- 2021/06/09 00:00 [accepted]
PHST- 2021/06/16 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/06/15 20:12 [entrez]
AID - S0047-6374(21)00092-0 [pii]
AID - 10.1016/j.mad.2021.111520 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2021 Jul;197:111520. doi: 10.1016/j.mad.2021.111520. Epub 2021 
      Jun 12.