PMID- 34130473
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 0001-723X (Print)
IS  - 0001-723X (Linking)
VI  - 65
IP  - 2
DP  - 2021
TI  - Genetic variation analysis of Type 2 porcine reproductive and respiratory 
      syndrome virus in Guangdong Province from 2016 to 2018.
PG  - 221-231
LID - 10.4149/av_2021_213 [doi]
AB  - Porcine reproductive and respiratory syndrome virus (PRRSV) is a notable threat 
      to the pig industry. Long-term epidemiological investigations and genetic 
      variation analyses of PRRSV isolates benefit PRRSV prevention and control. In our 
      study, 43 PRRSV strains were  successfully isolated from the lungs of sick pigs, 
      and the genetic variations of these isolates were analyzed. Phylogenetic analysis 
      showed that the isolates belonged to PRRSV2 and that lineage 8 (8.7) subgroup III 
      strains remained the dominant type circulating in South China. In addition, 
      sequence alignment analysis identified many novel deletions and mutations in the 
      Nsp2 and GP5 genes. Furthermore, phylogenetic analysis showed that highly 
      frequent recombination events of PRRSV between different lineages might occur in 
      Guangdong Province. These results may help to elucidate the epidemiology and 
      genetic variation of PRRSV isolates in Guangdong Province. Keywords: GP5; Nsp2; 
      phylogenetic analysis; sequence alignment; porcine reproductive and respiratory 
      syndrome virus (PRRSV).
FAU - Zhao, Pandeng
AU  - Zhao P
FAU - Yu, Linyang
AU  - Yu L
FAU - Liu, Yanling
AU  - Liu Y
FAU - Zhang, Leyi
AU  - Zhang L
FAU - Liang, Pengshuai
AU  - Liang P
FAU - Wang, Lei
AU  - Wang L
FAU - Jing, Huiyuan
AU  - Jing H
FAU - Huang, Li
AU  - Huang L
FAU - Song, Changxu
AU  - Song C
FAU - Dong, Jianguo
AU  - Dong J
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Acta Virol
JT  - Acta virologica
JID - 0370401
SB  - IM
MH  - Animals
MH  - China/epidemiology
MH  - Genetic Variation
MH  - Phylogeny
MH  - *Porcine Reproductive and Respiratory Syndrome/epidemiology
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - Swine
EDAT- 2021/06/17 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/06/16 05:32
PHST- 2021/06/16 05:32 [entrez]
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
AID - 10.4149/av_2021_213 [doi]
PST - ppublish
SO  - Acta Virol. 2021;65(2):221-231. doi: 10.4149/av_2021_213.