PMID- 34130874
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20220531
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 78
IP  - 5
DP  - 2021 Nov
TI  - Acute atrial ischemia associates with early but not late new-onset atrial 
      fibrillation in STEMI patients treated with primary PCI: relationship with 
      in-hospital outcomes.
PG  - 368-374
LID - S0914-5087(21)00136-2 [pii]
LID - 10.1016/j.jjcc.2021.05.013 [doi]
AB  - BACKGROUND: New-onset atrial fibrillation (NOAF), both early (EAF) or late (LAF), 
      may complicate ST-segment elevation myocardial infarction (STEMI). The mechanisms 
      underlying EAF or LAF are poorly described. We investigated atrial branch 
      occlusion and EAF or LAF onset in STEMI patients undergoing primary percutaneous 
      coronary intervention. METHODS: This was a retrospective cohort study including 
      155 STEMI patients. Patients were divided into 3 groups: sinus rhythm (SR), EAF, 
      or LAF. Clinical characteristics, angiographic features including occlusion of 
      atrial branches, namely ramus ostia cavae superioris (ROCS), atrio-ventricular 
      node artery (AVNA), right intermediate atrial artery (RIAA), and left 
      intermediate atrial artery, were assessed. We also investigated in-hospital 
      adverse events (AEs) and death. RESULTS: Mean age was 63.8+/-11.9 years; 78.7% were 
      men. NOAF was detected in 22 (14.2%) patients: 10 (6.4%) EAF and 12 LAF (7.7%). 
      Compared to EAF, LAF patients were older (p=0.013), with higher GRACE risk score 
      (p=0.014) and Killip class (p=0.015), depressed ejection fraction (p=0.007), 
      elevated filling pressures (p=0.029), higher C-reactive protein (p=0.014) and 
      more with thrombolysis in myocardial infarction flow <3 (p=0.015). Compared to 
      SR, EAF was associated with higher prevalence of occluded ROCS (p=0.010), AVNA 
      (p=0.005), and RIAA (p<0.001). Moreover, EAF patients had more frequently >/=2 
      diseased atrial branches than SR (19.5%, p<0.001) and LAF (25%, p<0.030) 
      patients. LAF patients had a higher in-hospital AEs (p=0.019 vs SR; p=0.029 vs 
      EAF) and death (p=0.004 vs SR). CONCLUSIONS: The occlusion of atrial branches is 
      associated with EAF but not LAF following STEMI. LAF patients had worse 
      in-hospital AEs and mortality.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Biccire, Flavio Giuseppe
AU  - Biccire FG
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Pastori, Daniele
AU  - Pastori D
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy. Electronic address: 
      daniele.pastori@uniroma1.it.
FAU - Torromeo, Concetta
AU  - Torromeo C
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Acconcia, Maria Cristina
AU  - Acconcia MC
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Capone, Silvia
AU  - Capone S
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Ferrari, Ilaria
AU  - Ferrari I
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Pannarale, Giuseppe
AU  - Pannarale G
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Paravati, Vincenzo
AU  - Paravati V
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Gaudio, Carlo
AU  - Gaudio C
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Tanzilli, Gaetano
AU  - Tanzilli G
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy.
FAU - Barilla, Francesco
AU  - Barilla F
AD  - Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, 
      Sapienza University of Rome, Rome, Italy; Department of Systems Medicine, 
      University of Rome Tor Vergata, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210612
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - Aged
MH  - *Atrial Fibrillation
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *ST Elevation Myocardial Infarction/surgery
OTO - NOTNLM
OT  - Acute myocardial Infarction
OT  - Atrial fibrillation
OT  - Cardiovascular events
OT  - Cardiovascular pathophysiology
OT  - ST-segment elevation myocardial infarction
EDAT- 2021/06/17 06:00
MHDA- 2021/12/01 06:00
CRDT- 2021/06/16 05:58
PHST- 2021/04/07 00:00 [received]
PHST- 2021/05/10 00:00 [revised]
PHST- 2021/05/14 00:00 [accepted]
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/06/16 05:58 [entrez]
AID - S0914-5087(21)00136-2 [pii]
AID - 10.1016/j.jjcc.2021.05.013 [doi]
PST - ppublish
SO  - J Cardiol. 2021 Nov;78(5):368-374. doi: 10.1016/j.jjcc.2021.05.013. Epub 2021 Jun 
      12.