PMID- 34130898
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220107
IS  - 1532-8422 (Electronic)
IS  - 1053-0770 (Linking)
VI  - 35
IP  - 12
DP  - 2021 Dec
TI  - Correlation Between Intraventricular Pressure Difference and Indexed Flow of a 
      Left Ventricular Assist Device.
PG  - 3626-3630
LID - S1053-0770(21)00448-1 [pii]
LID - 10.1053/j.jvca.2021.05.035 [doi]
AB  - OBJECTIVES: There is no definitive parameter for left ventricular (LV) preload in 
      patients with a continuous-flow left ventricular assist device (LVAD). The 
      intraventricular pressure difference (IVPD) is the maximum pressure difference 
      between the mitral valve and LV apex during diastole; and, in past studies, the 
      IVPD was influenced by volume loading. The authors hypothesized that IVPD in LVAD 
      patients correlates with indexed LVAD flow and that IVPD can serve as a novel 
      parameter of LV preload in this population. DESIGN: A single-center, 
      retrospective, observational study. SETTING: A tertiary-care hospital from August 
      2019 to July 2020. PARTICIPANTS: Sixteen ramp tests for adjustment of LVAD pump 
      speed in 14 adult patients undergoing continuous-flow LVAD implantation. 
      INTERVENTIONS: Measurement of IVPD during ramp tests. MEASUREMENTS AND MAIN 
      RESULTS: LVAD flow and IVPD were measured at each LVAD pump speed during the ramp 
      test for the adjustment of LVAD pump speed after patients came off 
      cardiopulmonary bypass during LVAD implantation. A straight, longitudinal view of 
      the left atrium and left ventricle was obtained, and the pressure difference 
      between the mitral valve and LV apex during diastole was measured by 
      transesophageal echocardiography. The maximum pressure difference during diastole 
      was recorded as IVPD. The relationship between indexed LVAD flow (LVAD flow/body 
      surface area) and IVPD was assessed by a multivariate nonlinear regression 
      analysis with the Huber-White sandwich estimator. IVPD correlated with indexed 
      LVAD flow (p < 0.001). CONCLUSIONS: IVPD is a useful indicator of LV preload 
      during LVAD implantation.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Maekawa, Masaki
AU  - Maekawa M
AD  - Department of Anesthesiology, Toranomon Hospital, Tokyo, Japan.
FAU - Minami, Kimito
AU  - Minami K
AD  - Department of Surgical Intensive Care, National Cerebral and Cardiovascular 
      Center, Osaka, Japan. Electronic address: k.minami@ncvc.go.jp.
FAU - Yoshitani, Kenji
AU  - Yoshitani K
AD  - Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka, 
      Japan.
FAU - Watanabe, Kenji
AU  - Watanabe K
AD  - Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka, 
      Japan.
FAU - Kanazawa, Hiroko
AU  - Kanazawa H
AD  - Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka, 
      Japan.
FAU - Tadokoro, Naoki
AU  - Tadokoro N
AD  - Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, 
      Osaka, Japan.
FAU - Fukushima, Satsuki
AU  - Fukushima S
AD  - Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, 
      Osaka, Japan.
FAU - Fujita, Tomoyuki
AU  - Fujita T
AD  - Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, 
      Osaka, Japan.
FAU - Ohnishi, Yoshihiko
AU  - Ohnishi Y
AD  - Department of Anesthesiology, National Cerebral and Cardiovascular Center, Osaka, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210523
PL  - United States
TA  - J Cardiothorac Vasc Anesth
JT  - Journal of cardiothoracic and vascular anesthesia
JID - 9110208
SB  - IM
MH  - Adult
MH  - Diastole
MH  - *Heart Failure/diagnostic imaging/surgery
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Retrospective Studies
MH  - Ventricular Function, Left
MH  - Ventricular Pressure
OTO - NOTNLM
OT  - intraventricular pressure difference
OT  - left ventricular assist device
OT  - ramp test
COIS- Conflict of Interest None.
EDAT- 2021/06/17 06:00
MHDA- 2022/01/08 06:00
CRDT- 2021/06/16 05:59
PHST- 2021/01/14 00:00 [received]
PHST- 2021/05/11 00:00 [revised]
PHST- 2021/05/13 00:00 [accepted]
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2021/06/16 05:59 [entrez]
AID - S1053-0770(21)00448-1 [pii]
AID - 10.1053/j.jvca.2021.05.035 [doi]
PST - ppublish
SO  - J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3626-3630. doi: 
      10.1053/j.jvca.2021.05.035. Epub 2021 May 23.