PMID- 34130918
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 31
IP  - 1
DP  - 2022 Jan
TI  - Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic 
      Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy.
PG  - 110-118
LID - S1443-9506(21)00552-7 [pii]
LID - 10.1016/j.hlc.2021.05.090 [doi]
AB  - BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of 
      pulmonary embolism, and pulmonary endarterectomy (PEA) is the surgical treatment. 
      Asymmetric dimethylarginine (ADMA) levels are increased in pulmonary 
      hypertension. This study aimed to investigate serum ADMA levels in patients with 
      CTEPH, the effect of PEA on ADMA, and its prognostic value in long-term 
      mortality. METHOD: Eighty (80) patients with CTEPH and 32 healthy controls were 
      included. Preoperative serum ADMA levels, determined using an enzyme-linked 
      immunosorbent assay, were compared between patients with CTEPH and controls. Of 
      80 patients, 64 had PEA. Pre- and 6-month postoperative serum ADMA levels, 
      6-minute walk distance (6MWD), and haemodynamic parameters were collected from 
      patients undergoing PEA. Patients were followed-up for survival analysis. 
      RESULTS: Mean +/- standard deviation serum ADMA levels were significantly higher in 
      patients with CTEPH compared with controls (0.79+/-0.32 mumol/L vs 0.52+/-0.12 mumol/L; 
      p=0.0001). Statistically significant differences were observed between 
      preoperative and postoperative serum ADMA levels (0.78+/-0.30 mumol/L vs 0.62+/-0.22 
      mumol/L; p=0.0001), 6MWD (p=0.0001), and pulmonary vascular resistance (p=0.0001) 
      in 60 patients who underwent and survived PEA. The decrease in serum ADMA levels 
      and increase in 6MWD were significantly correlated (r=-0.286, p=0.027). No other 
      correlation was found. Perioperative mortality was 6.3%, and the survival rate 
      with a mean follow-up of 34.57+/-8.20 months was 93.3%. Patients with serum ADMA 
      levels >0.8 mumol/L had a significantly lower survival rate (logrank: 5.86; 
      p=0.015). CONCLUSIONS: Levels of circulating ADMA might add diagnostic and 
      prognostic information in CTEPH. Pulmonary endarterectomy is associated with an 
      improvement in serum ADMA levels. Preoperative serum ADMA levels may be useful 
      for estimating the outcome of PEA.
CI  - Copyright (c) 2021 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Turer Cabbar, Ayca
AU  - Turer Cabbar A
AD  - Department of Cardiology, Yeditepe University School of Medicine, Istanbul, 
      Turkey. Electronic address: turerayca@gmail.com.
FAU - Degertekin, M Muzaffer
AU  - Degertekin MM
AD  - Department of Cardiology, Yeditepe University School of Medicine, Istanbul, 
      Turkey.
FAU - Simsek, Mustafa A
AU  - Simsek MA
AD  - Department of Cardiology, Yeditepe University School of Medicine, Istanbul, 
      Turkey.
FAU - Ozveren, Olcay
AU  - Ozveren O
AD  - Department of Cardiology, Yeditepe University School of Medicine, Istanbul, 
      Turkey.
FAU - Gulec, Seda
AU  - Gulec S
AD  - Department of Medical Biology, Yeditepe University School of Medicine, Istanbul, 
      Turkey.
FAU - Yanartas, Mehmed
AU  - Yanartas M
AD  - Department of Cardiovascular Surgery, Kartal Kosuyolu High Specialty Educational 
      and Research Hospital, Istanbul, Turkey.
FAU - Gezer Tas, Serpil
AU  - Gezer Tas S
AD  - Department of Cardiovascular Surgery, Kartal Kosuyolu High Specialty Educational 
      and Research Hospital, Istanbul, Turkey.
FAU - Olgun Yildizeli, Sehnaz
AU  - Olgun Yildizeli S
AD  - Department of Pulmonary and Intensive Care, Marmara University Istanbul Pendik 
      Educational and Research Hospital, Istanbul, Turkey.
FAU - Mutlu, Bulent
AU  - Mutlu B
AD  - Department of Cardiology, Marmara University Istanbul Pendik Educational and 
      Research Hospital, Istanbul, Turkey.
FAU - Isbir, Turgay
AU  - Isbir T
AD  - Department of Medical Biology, Yeditepe University School of Medicine, Istanbul, 
      Turkey.
FAU - Yildizeli, Bedrettin
AU  - Yildizeli B
AD  - Department of Thoracic Surgery, Marmara University Istanbul Pendik Educational 
      and Research Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210612
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Arginine/analogs & derivatives
MH  - Chronic Disease
MH  - Endarterectomy
MH  - Humans
MH  - *Hypertension, Pulmonary/diagnosis/surgery
OTO - NOTNLM
OT  - Asymmetric dimethylarginine
OT  - Chronic thromboembolic pulmonary hypertension
OT  - Pulmonary endarterectomy
EDAT- 2021/06/17 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/06/16 06:00
PHST- 2021/01/17 00:00 [received]
PHST- 2021/04/13 00:00 [revised]
PHST- 2021/05/10 00:00 [accepted]
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/06/16 06:00 [entrez]
AID - S1443-9506(21)00552-7 [pii]
AID - 10.1016/j.hlc.2021.05.090 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2022 Jan;31(1):110-118. doi: 10.1016/j.hlc.2021.05.090. Epub 
      2021 Jun 12.