PMID- 34133255
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20210922
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 97
IP  - 9
DP  - 2021
TI  - An intercomparison exercise to compare scoring criteria and develop image 
      databank for biodosimetry in South Korea.
PG  - 1199-1205
LID - 10.1080/09553002.2021.1941384 [doi]
AB  - PURPOSE: Mutual cooperation of biodosimetry laboratories is required for dose 
      assessments of large numbers of people with potential radiation exposure, as in 
      mass casualty accidents. We launched an intercomparison exercise to validate the 
      performance of biodosimetry laboratories in South Korea. MATERIALS AND METHODS: 
      Participating laboratories shared metaphase images from dicentric chromosome 
      assays (DCAs) and fluorescence in situ hybridization (FISH)-based translocation 
      assays, which were evaluated based on their own scoring protocols. RESULTS: 
      Overall, the coefficient of variation among three laboratories was less than 10% 
      for counting scorable metaphases and chromosomal aberrations. However, there was 
      variation in the interpretation of the International Atomic Energy Agency 
      guidelines for selecting scorable metaphases and identifying chromosomal 
      aberrations. In a technical workshop, scoring discrepancies were extensively 
      discussed in order to harmonize biodosimetry protocols in Korea. In addition, 
      metaphase images with agreement among all participating laboratories were 
      compiled into an image databank, which can be used for education and training of 
      scorers. CONCLUSIONS: These findings and exercises may improve the accuracy of 
      dose assessment, as well as increase the capacity for biodosimetry in South 
      Korea.
FAU - Lee, Yang Hee
AU  - Lee YH
AUID- ORCID: 0000-0002-9537-3306
AD  - Lab of Biological Dosimetry, National Radiation Emergency Medical Center (NREMC), 
      Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Republic of 
      Korea.
FAU - Lee, Younghyun
AU  - Lee Y
AUID- ORCID: 0000-0003-0633-7248
AD  - Lab of Biological Dosimetry, National Radiation Emergency Medical Center (NREMC), 
      Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Republic of 
      Korea.
FAU - Yoon, Hyo Jin
AU  - Yoon HJ
AUID- ORCID: 0000-0003-1976-5276
AD  - Lab of Biological Dosimetry, National Radiation Emergency Medical Center (NREMC), 
      Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Republic of 
      Korea.
FAU - Yang, Su San
AU  - Yang SS
AD  - Lab of Biological Dosimetry, National Radiation Emergency Medical Center (NREMC), 
      Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Republic of 
      Korea.
FAU - Joo, Hae Mi
AU  - Joo HM
AD  - Korea Hydro & Nuclear Power Co, Radiation Health Institute, Seoul, Republic of 
      Korea.
FAU - Kim, Ji Young
AU  - Kim JY
AD  - Korea Hydro & Nuclear Power Co, Radiation Health Institute, Seoul, Republic of 
      Korea.
FAU - Cho, Seong-Jun
AU  - Cho SJ
AD  - Korea Hydro & Nuclear Power Co, Radiation Health Institute, Seoul, Republic of 
      Korea.
FAU - Jo, Wol Soon
AU  - Jo WS
AUID- ORCID: 0000-0003-2823-0994
AD  - Department of Research Center, Dong Nam Institute of Radiological and Medical 
      Sciences (DIRAMS), Busan, Republic of Korea.
FAU - Jeong, Soo Kyung
AU  - Jeong SK
AUID- ORCID: 0000-0003-0622-7225
AD  - Department of Research Center, Dong Nam Institute of Radiological and Medical 
      Sciences (DIRAMS), Busan, Republic of Korea.
FAU - Oh, Su Jung
AU  - Oh SJ
AUID- ORCID: 0000-0002-0457-4146
AD  - Department of Research Center, Dong Nam Institute of Radiological and Medical 
      Sciences (DIRAMS), Busan, Republic of Korea.
FAU - Kang, Yeong-Rok
AU  - Kang YR
AUID- ORCID: 0000-0003-2981-6559
AD  - Department of Research Center, Dong Nam Institute of Radiological and Medical 
      Sciences (DIRAMS), Busan, Republic of Korea.
FAU - Seong, Ki Moon
AU  - Seong KM
AUID- ORCID: 0000-0003-3530-5587
AD  - Lab of Biological Dosimetry, National Radiation Emergency Medical Center (NREMC), 
      Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul, Republic of 
      Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210707
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Chromosome Aberrations/radiation effects
MH  - *Databases, Factual
MH  - In Situ Hybridization, Fluorescence
MH  - Radiation Dosage
MH  - Radiation Exposure
MH  - *Radiometry
MH  - Republic of Korea
OTO - NOTNLM
OT  - Biodosimetry
OT  - cytogenetics
OT  - intercomparison
OT  - radiation
EDAT- 2021/06/17 06:00
MHDA- 2021/09/23 06:00
CRDT- 2021/06/16 17:20
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/06/16 17:20 [entrez]
AID - 10.1080/09553002.2021.1941384 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2021;97(9):1199-1205. doi: 10.1080/09553002.2021.1941384. Epub 
      2021 Jul 7.