PMID- 34133512
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20221209
IS  - 1678-4227 (Electronic)
IS  - 0004-282X (Print)
IS  - 0004-282X (Linking)
VI  - 79
IP  - 4
DP  - 2021 Apr
TI  - Electroencephalographic findings among inpatients with COVID-19 in a tertiary 
      hospital from a middle-income country.
PG  - 315-320
LID - S0004-282X2021000400315 [pii]
LID - 10.1590/0004-282X-ANP-2020-0555 [doi]
AB  - BACKGROUND: In 2019, the world witnessed the emergence of a new type of 
      coronavirus - the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 
      The spectrum of coronavirus disease 2019 (COVID-19) is variable, and amongst its 
      manifestations are neurological implications. OBJECTIVE: This report aimed to 
      describe electroencephalographic findings in COVID-19 patients from a general 
      tertiary hospital in Sao Paulo, Brazil. METHODS: It was a retrospective, 
      observational, and non-interventional study. Data were collected anonymously, 
      comprising inpatients from Mar 1 to Jun 30, 2020, either confirmed (positive 
      RT-PCR) or probable cases (CO-RADS 4/5) who had performed EEG during 
      hospitalization. RESULTS: Twenty-eight patients were enrolled, 17 (60.7%) women 
      and 11 men, with a median age of 58 (minimum and maximum: 18-86; IQR 23.5). 
      COVID-19 diagnosis was confirmed in 22 (78.5%). Twenty-one patients (75%) had 
      severe disease, requiring mechanical ventilation due to acute respiratory 
      distress syndrome (ARDS); 16 (57.1%) patients developed adjunct sepsis throughout 
      hospitalization. There was no specific pattern found for COVID-19 in EEG. No 
      patients presented with status epilepticus or electrographic events; most 
      patients developed an encephalopathic pattern, as seen in most studies, with a 
      high prevalence of altered mental status as an indication for EEG. Adjunct sepsis 
      was associated with higher mortality. CONCLUSIONS: EEG presents as a useful tool 
      in the context of COVID-19, as in other conditions, to differentiate 
      nonconvulsive status epilepticus (NCSE) from encephalopathy and other causes of 
      mental status alterations. Further studies are required to analyze whether there 
      might be a specific EEG pattern to the disease.
FAU - Corazza, Luiza Alves
AU  - Corazza LA
AUID- ORCID: 0000-0001-7866-7786
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Tatsch, Joao Fellipe Santos
AU  - Tatsch JFS
AUID- ORCID: 0000-0002-6807-5004
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Barros, Maraysa Pereira
AU  - Barros MP
AUID- ORCID: 0000-0002-2952-9237
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Queiroz, Apolonio Peixoto de
AU  - Queiroz AP
AUID- ORCID: 0000-0002-5598-7389
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Batista, Luana Lobo Ribeiro
AU  - Batista LLR
AUID- ORCID: 0000-0003-2378-6424
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Aidar, Mariana Barbosa
AU  - Aidar MB
AUID- ORCID: 0000-0001-5073-4588
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Baldocchi, Meire Argentoni
AU  - Baldocchi MA
AUID- ORCID: 0000-0002-2125-9455
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Rocha, Maria Sheila Guimaraes
AU  - Rocha MSG
AUID- ORCID: 0000-0003-4312-3994
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
FAU - Brucki, Sonia Maria Dozzi
AU  - Brucki SMD
AUID- ORCID: 0000-0002-8303-6732
AD  - Hospital Santa Marcelina, Departamento de Neurologia, Sao Paulo SP, Brazil.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arq Neuropsiquiatr
JT  - Arquivos de neuro-psiquiatria
JID - 0125444
SB  - IM
MH  - Brazil
MH  - *COVID-19
MH  - COVID-19 Testing
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - *Inpatients
MH  - Male
MH  - Retrospective Studies
MH  - SARS-CoV-2
MH  - Tertiary Care Centers
PMC - PMC9231444
COIS- Conflict of interest: There is no conflict of interest to declare.
EDAT- 2021/06/17 06:00
MHDA- 2021/06/25 06:00
PMCR- 2021/05/08
CRDT- 2021/06/16 17:30
PHST- 2020/11/27 00:00 [received]
PHST- 2021/02/16 00:00 [accepted]
PHST- 2021/06/16 17:30 [entrez]
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2021/05/08 00:00 [pmc-release]
AID - S0004-282X2021000400315 [pii]
AID - 10.1590/0004-282X-ANP-2020-0555 [doi]
PST - ppublish
SO  - Arq Neuropsiquiatr. 2021 Apr;79(4):315-320. doi: 10.1590/0004-282X-ANP-2020-0555.