PMID- 34134112
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20211230
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 94
IP  - 1-2
DP  - 2021
TI  - Adult Height in 299 Patients with Turner Syndrome with or without Growth Hormone 
      Therapy: Results and Literature Review.
PG  - 63-70
LID - 10.1159/000516869 [doi]
AB  - CONTEXT: Treatment with growth hormone (GH) is considered effective in improving 
      adult height (AH) in Turner syndrome (TS). However, there are few studies 
      comparing AH between treated patients and a concurrent untreated group. 
      OBJECTIVE: To assess the efficacy of GH treatment in improving AH in TS and to 
      review previous published studies with treated and untreated groups. PARTICIPANTS 
      AND METHODS: We retrospectively analyzed clinical data and AH of a large cohort 
      of GH-treated (n = 168) and untreated (n = 131) patients with TS. Data are shown 
      as median and interquartile range (IQR). We assessed pretreatment variables 
      related with AH and compared our results with 16 studies that also included an 
      untreated group. RESULTS: The GH-treated group was 6.2 cm taller than the 
      untreated group (AH = 149 cm [IQR 144.5-152.5 cm] vs. 142.8 cm [IQR 139-148 cm], 
      p < 0.001) after 4.9 years of GH treatment with a dose of 0.35 mg/kg/week. AH SDS 
      corrected for target height (TH) was 7.2 cm higher in GH-treated patients. AH SDS 
      >/=-2 was more frequent in GH-treated patients (43%) than in untreated patients 
      (16%, p < 0.001). AH SDS was also more frequently within the TH range in the 
      GH-treated group (52%) than in the untreated group (15%, p < 0.001). Height SDS 
      at start of GH therapy and TH SDS were positively correlated with AH (p < 0.001; 
      R2 = 0.375). Considering the current result together with previous similar 
      publications, a mean AH gain of 5.7 cm was observed in GH-treated (n = 696) 
      versus untreated (n = 633) patients. CONCLUSIONS: Our study strengthens the 
      evidence for efficacy of GH therapy in patients with TS from different 
      populations.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Dantas, Naiara C B
AU  - Dantas NCB
AD  - Unidade de Endocrinologia Genetica, Laboratorio de Endocrinologia Celular e 
      Molecular LIM/25, Disciplina de Endocrinologia, Faculdade de Medicina da 
      Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Braz, Adriana F
AU  - Braz AF
AD  - Unidade Academica de Medicina, Faculdade de Medicina, Universidade Federal de 
      Campina Grande, Campina Grande, Brazil.
FAU - Malaquias, Alexsandra
AU  - Malaquias A
AD  - Departamento de Pediatria, Faculdade de Ciencias Medicas da Santa Casa de Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Lemos-Marini, Sofia
AU  - Lemos-Marini S
AD  - Departamento de Pediatria, Faculdade de Ciencias Medicas, Universidade Estadual 
      de Campinas, Campinas, Brazil.
FAU - Arnhold, Ivo J P
AU  - Arnhold IJP
AD  - Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica 
      Molecular LIM/42, Disciplina de Endocrinologia, Faculdade de Medicina da 
      Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Silveira, Ester R
AU  - Silveira ER
AD  - Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, Ribeirao Preto, Brazil.
FAU - Antonini, Sonir R
AU  - Antonini SR
AD  - Departamento de Pediatria, Faculdade de Medicina de Ribeirao Preto, Universidade 
      de Sao Paulo, Ribeirao Preto, Brazil.
FAU - Guerra-Junior, Gil
AU  - Guerra-Junior G
AD  - Departamento de Pediatria, Faculdade de Ciencias Medicas, Universidade Estadual 
      de Campinas, Campinas, Brazil.
FAU - Mendonca, Berenice
AU  - Mendonca B
AD  - Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica 
      Molecular LIM/42, Disciplina de Endocrinologia, Faculdade de Medicina da 
      Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Jorge, Alexander
AU  - Jorge A
AD  - Unidade de Endocrinologia Genetica, Laboratorio de Endocrinologia Celular e 
      Molecular LIM/25, Disciplina de Endocrinologia, Faculdade de Medicina da 
      Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Scalco, Renata C
AU  - Scalco RC
AD  - Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica 
      Molecular LIM/42, Disciplina de Endocrinologia, Faculdade de Medicina da 
      Universidade de Sao Paulo, Sao Paulo, Brazil.
AD  - Departamento de Medicina, Faculdade de Ciencias Medicas da Santa Casa de Sao 
      Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210616
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adult
MH  - Body Height/*drug effects
MH  - Female
MH  - Growth Disorders/*drug therapy/etiology/physiopathology
MH  - Human Growth Hormone/administration & dosage/*therapeutic use
MH  - Humans
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Turner Syndrome/*complications/drug therapy/physiopathology
OTO - NOTNLM
OT  - Adult height
OT  - Growth hormone therapy
OT  - Turner syndrome
EDAT- 2021/06/17 06:00
MHDA- 2021/12/31 06:00
CRDT- 2021/06/16 20:15
PHST- 2020/12/30 00:00 [received]
PHST- 2021/04/21 00:00 [accepted]
PHST- 2021/06/17 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
PHST- 2021/06/16 20:15 [entrez]
AID - 000516869 [pii]
AID - 10.1159/000516869 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2021;94(1-2):63-70. doi: 10.1159/000516869. Epub 2021 Jun 16.