PMID- 34134880 OWN - NLM STAT- MEDLINE DCOM- 20210805 LR - 20231222 IS - 1873-6483 (Electronic) IS - 0740-5472 (Print) IS - 0740-5472 (Linking) VI - 127 DP - 2021 Aug TI - A pilot randomized clinical trial of mindfulness-oriented recovery enhancement as an adjunct to methadone treatment for people with opioid use disorder and chronic pain: Impact on illicit drug use, health, and well-being. PG - 108468 LID - S0740-5472(21)00194-X [pii] LID - 10.1016/j.jsat.2021.108468 [doi] AB - BACKGROUND: Chronic pain is highly prevalent among people in methadone maintenance treatment (MMT) for opioid use disorder and is known to be an important contributor to treatment discontinuation and opioid relapse. Mindfulness-Oriented Recovery Enhancement (MORE) is one of the few interventions developed and tested as an integrated treatment to simultaneously address both pain and illicit opioid use; however, this study is the first to evaluate MORE as an adjunct to MMT. METHODS: Randomized individuals in MMT (N = 30) received MORE plus methadone TAU (n = 15) or methadone TAU, only (n = 15). Participants in the MORE arm received their MMT, as usual, and attended eight, weekly, two-hour MORE groups at their MMT clinics. Participants in the TAU arm received their MMT, as usual, and group or individual counseling, as required by the clinic. TAU counseling consisted of relapse prevention, cognitive-behavioral therapy, and supportive treatment. TAU participants did not receive any mindfulness-based intervention. Participants completed assessments at baseline, post-treatment (i.e., 8-weeks post-baseline), and follow-up (i.e., 16-weeks post-baseline). RESULTS: Participants in MORE evidenced significantly fewer baseline adjusted days of illicit drug use and significantly lower levels of craving through 16-week follow-up compared to TAU. Also, Participants in MORE reported significantly lower levels of pain, physical and emotional limitations, depression, and anxiety through 16-week follow-up compared to TAU. Conversely, participants in MORE reported significantly higher levels of well-being, vitality, and social functioning through 16-week follow-up compared to TAU. CONCLUSION: MORE could be an effective adjunct to MMT, and larger trials are warranted. CI - Copyright (c) 2021 Elsevier Inc. All rights reserved. FAU - Cooperman, Nina A AU - Cooperman NA AD - Division of Addiction Psychiatry, Rutgers Robert Wood Johnson Medical School, 317 George Street, Suite 105, New Brunswick, NJ 08502, USA. Electronic address: cooperna@rwjms.rutgers.edu. FAU - Hanley, Adam W AU - Hanley AW AD - College of Social Work, University of Utah, Goodwill Humanitarian Building, 395 South, 1500 East, Room 273, Salt Lake City 84108, USA; Center on Mindfulness and Integrative Health Intervention Development, University of Utah, 395 South, 1500 East, Room 273, Salt Lake City 84108, USA. FAU - Kline, Anna AU - Kline A AD - Division of Addiction Psychiatry, Rutgers Robert Wood Johnson Medical School, 317 George Street, Suite 105, New Brunswick, NJ 08502, USA. FAU - Garland, Eric L AU - Garland EL AD - College of Social Work, University of Utah, Goodwill Humanitarian Building, 395 South, 1500 East, Room 273, Salt Lake City 84108, USA; Center on Mindfulness and Integrative Health Intervention Development, University of Utah, 395 South, 1500 East, Room 273, Salt Lake City 84108, USA. LA - eng GR - R21 AT010109/AT/NCCIH NIH HHS/United States GR - R33 AT010109/AT/NCCIH NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural DEP - 20210508 PL - United States TA - J Subst Abuse Treat JT - Journal of substance abuse treatment JID - 8500909 RN - 0 (Analgesics, Opioid) RN - 0 (Illicit Drugs) RN - UC6VBE7V1Z (Methadone) SB - IM MH - Analgesics, Opioid/therapeutic use MH - *Chronic Pain/drug therapy MH - Humans MH - *Illicit Drugs MH - Methadone/therapeutic use MH - *Mindfulness MH - Opiate Substitution Treatment MH - *Opioid-Related Disorders/drug therapy MH - Pilot Projects PMC - PMC8281569 MID - NIHMS1702074 OTO - NOTNLM OT - Chronic pain OT - MORE OT - Methadone OT - Mindfulness OT - Opioid OT - Savoring EDAT- 2021/06/18 06:00 MHDA- 2021/08/06 06:00 PMCR- 2022/08/01 CRDT- 2021/06/17 05:48 PHST- 2020/12/07 00:00 [received] PHST- 2021/04/30 00:00 [revised] PHST- 2021/04/30 00:00 [accepted] PHST- 2021/06/17 05:48 [entrez] PHST- 2021/06/18 06:00 [pubmed] PHST- 2021/08/06 06:00 [medline] PHST- 2022/08/01 00:00 [pmc-release] AID - S0740-5472(21)00194-X [pii] AID - 10.1016/j.jsat.2021.108468 [doi] PST - ppublish SO - J Subst Abuse Treat. 2021 Aug;127:108468. doi: 10.1016/j.jsat.2021.108468. Epub 2021 May 8.