PMID- 34135577
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20220424
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 16
DP  - 2021
TI  - Potentially Inappropriate Medication and Associated Factors Among Older Patients 
      with Chronic Coronary Syndrome at Hospital Discharge in Beijing, China.
PG  - 1047-1056
LID - 10.2147/CIA.S305006 [doi]
AB  - PURPOSE: Medication therapy is crucial in the management of chronic coronary 
      syndrome (CCS). The use of potentially inappropriate medications (PIMs) 
      contributes to poor outcomes in older patients, making it a major public health 
      concern. However, few studies are available on PIMs use in older Chinese CCS 
      patients. To investigate the frequency of prescribed PIMs at discharge and 
      explore risk factors in older adults with CCS. PATIENTS AND METHODS: The 
      cross-sectional study was conducted in a tertiary hospital in China over three 
      months, from 1st October to 31st December, 2019. CCS patients aged over 60 years 
      who were discharged alive were recruited. Information on demographics and 
      medications at discharge was collected. Clinical data including diagnoses, 
      frailty status, New York Heart Association (NYHA) class and age-adjusted Charlson 
      Comorbidity Index (ACCI) were evaluated in each patient. PIMs were identified 
      using the 2019 Beers criteria. Binary logistic regression was performed to 
      recognize variables related to PIMs. RESULTS: A total of 447 eligible patients 
      with 2947 medications were included. The prevalence of PIMs use was 38%. 
      Medications to be avoided, to be used with caution, and with drug-drug 
      interactions were 38.4%, 48.9% and 12.7% of the PIMs, respectively. Medications 
      with drug-disease/syndrome interactions and those adjusted for kidney function 
      were not identified. The common PIMs were diuretics (37.1%), benzodiazepines and 
      benzodiazepine receptor agonist hypnotics (15.2%), glimepiride (13.1%), and 
      co-prescription of potassium-sparing diuretics and renin-angiotensin system (RAS) 
      inhibitors (9.7%). Individuals with frailty syndrome, polypharmacy, multiple 
      comorbidities, atrial fibrillation, psychiatric disorders and greater NYHA class 
      severity were more likely to receive PIMs. CONCLUSION: Prescription of PIMs was a 
      common burden in older adults. A CCS multidisciplinary team is needed to control 
      PIMs, especially in vulnerable older patients.
CI  - (c) 2021 Zhao et al.
FAU - Zhao, Mei
AU  - Zhao M
AUID- ORCID: 0000-0001-5092-7793
AD  - Department of Pharmacy, Peking University People's Hospital, Beijing, People's 
      Republic of China.
FAU - Song, Jun-Xian
AU  - Song JX
AD  - Department of Cardiology, Peking University People's Hospital, Beijing, People's 
      Republic of China.
FAU - Zheng, Fang-Fang
AU  - Zheng FF
AD  - Department of Cardiology, Peking University People's Hospital, Beijing, People's 
      Republic of China.
FAU - Huang, Lin
AU  - Huang L
AD  - Department of Pharmacy, Peking University People's Hospital, Beijing, People's 
      Republic of China.
FAU - Feng, Yu-Fei
AU  - Feng YF
AD  - Department of Pharmacy, Peking University People's Hospital, Beijing, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210609
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antihypertensive Agents/*adverse effects/therapeutic use
MH  - Beijing
MH  - Cardiovascular Diseases/*drug therapy/epidemiology
MH  - Cross-Sectional Studies
MH  - Frail Elderly/*statistics & numerical data
MH  - Humans
MH  - Inappropriate Prescribing/*adverse effects/statistics & numerical data
MH  - Logistic Models
MH  - Male
MH  - Patient Discharge/statistics & numerical data
MH  - Polypharmacy
MH  - Potentially Inappropriate Medication List/*statistics & numerical data
MH  - Prevalence
MH  - Risk Factors
MH  - Tertiary Care Centers
PMC - PMC8200161
OTO - NOTNLM
OT  - Beers criteria
OT  - chronic coronary syndrome
OT  - discharge
OT  - older adults
OT  - potentially inappropriate medication
COIS- The authors declare no conflicts of interest in this work.
EDAT- 2021/06/18 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/06/09
CRDT- 2021/06/17 06:37
PHST- 2021/02/05 00:00 [received]
PHST- 2021/05/23 00:00 [accepted]
PHST- 2021/06/17 06:37 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/06/09 00:00 [pmc-release]
AID - 305006 [pii]
AID - 10.2147/CIA.S305006 [doi]
PST - epublish
SO  - Clin Interv Aging. 2021 Jun 9;16:1047-1056. doi: 10.2147/CIA.S305006. eCollection 
      2021.