PMID- 34135850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210619
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 12
DP  - 2021
TI  - The Association Between Clinical Characteristics and Motor Symptom Laterality in 
      Patients With Parkinson's Disease.
PG  - 663232
LID - 10.3389/fneur.2021.663232 [doi]
LID - 663232
AB  - Background and Purpose: The unilateral onset and persistent asymmetry of motor 
      symptoms are important characteristics of Parkinson's disease (PD). By using 
      scales and wearable sensors, this study explored whether motor symptom laterality 
      could affect non-motor symptom and gait performance. Methods: A total of 130 
      right-handed patients with PD were enrolled in our study and were divided into 
      two groups according to the side of predominant motor symptom presentation by 
      using the Unified Parkinson's Disease Rating Scale part III. We measured the 
      non-motor symptoms with the Non-motor symptoms Scale, sleep quality with the 
      Parkinson's Disease Sleep Scale and Pittsburgh sleep quality index, cognitive 
      function with the Mini-mental State Examination and Montreal Cognitive 
      Assessment, quality of life with the Parkinson's Disease Questionnaire-39, and 
      the severity of anxiety and depression with the Hamilton Anxiety Scale and 
      Hamilton Depression Scale, respectively. All participants underwent the 
      instrumented stand and walk test, and gait data were collected using a set of 
      JiBuEn gait analysis system. Results: We observed that left-dominant symptom PD 
      patients (LPD) were associated with a greater impairment of sleep quality than 
      right-dominant symptom PD patients (RPD). We found no difference between LPD and 
      RPD in terms of gait performance. However, compared with the severe asymmetry RPD 
      patients (RPD-S), severe asymmetry LPD patients (LPD-S) showed a shorter stride 
      length and decreased range of motion of hip joints. Conclusions: In this study, 
      LPD was associated with a more severe sleep-related dysfunction than RPD. In 
      addition, LPD-S exhibited more gait impairments than RPD-S. Considering that 
      motor symptom laterality may affect the non-motor symptom and gait performance, 
      it should be taken into account when evaluating and treating PD patients.
CI  - Copyright (c) 2021 Zhu, Zhong, Bai, Wu, Gu, Jiang, Shen, Zhu, Pan, Dong, Xu, Yan 
      and Zhang.
FAU - Zhu, Sha
AU  - Zhu S
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Zhong, Min
AU  - Zhong M
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Bai, Yu
AU  - Bai Y
AD  - Department of Biological Sciences, University of Toronto Scarborough, Toronto, 
      ON, Canada.
FAU - Wu, Zhuang
AU  - Wu Z
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Gu, Ruxin
AU  - Gu R
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Jiang, Xu
AU  - Jiang X
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Shen, Bo
AU  - Shen B
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Pan, Yang
AU  - Pan Y
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Dong, Jingde
AU  - Dong J
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Xu, Pingyi
AU  - Xu P
AD  - Department of Neurology, First Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Yan, Jun
AU  - Yan J
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20210531
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8201506
OTO - NOTNLM
OT  - Parkinson's disease
OT  - asymmetry
OT  - gait analysis
OT  - motor
OT  - non-motor symptoms
OT  - wearable sensors
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/06/18 06:00
MHDA- 2021/06/18 06:01
PMCR- 2021/05/31
CRDT- 2021/06/17 06:41
PHST- 2021/02/02 00:00 [received]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/06/17 06:41 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/06/18 06:01 [medline]
PHST- 2021/05/31 00:00 [pmc-release]
AID - 10.3389/fneur.2021.663232 [doi]
PST - epublish
SO  - Front Neurol. 2021 May 31;12:663232. doi: 10.3389/fneur.2021.663232. eCollection 
      2021.