PMID- 34136169
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2048-7177 (Print)
IS  - 2048-7177 (Electronic)
IS  - 2048-7177 (Linking)
VI  - 9
IP  - 6
DP  - 2021 Jun
TI  - Association of serum selenium with anemia-related indicators and risk of anemia.
PG  - 3039-3047
LID - 10.1002/fsn3.2261 [doi]
AB  - Few studies have examined the association of serum selenium with anemia-related 
      indicators and risk of anemia. We conducted a cross-sectional analysis of 2,902 
      adults in 2003-2004 National Health and Nutrition Examination Survey database. 
      Multivariable linear and logistic regression models were used to examine the 
      association of serum selenium with anemia-related indicators and risk of anemia. 
      The nonlinear relationship was analyzed using a generalized additive model with 
      the smoothing plot. A total of 1,472 males and 1,430 females with a mean age of 
      61.94 +/- 13.73 years were included. Compared with the lowest quintile, the highest 
      quintile of serum selenium was associated with increased level of serum iron 
      (beta = 12.44, 95% confidence interval [CI]: 7.14, 17.75, p < .001), mean 
      corpuscular hemoglobin concentration (MCHC) (beta = 0.14, 95%CI: 0.02, 0.26, 
      p = .020), and hemoglobin (beta = 0.40, 95%CI: 0.19, 0.61, p < .001), and decreased 
      risk of anemia (odds ratio [OR] = 0.47, 95%CI: 0.28, 0.77, p = .002). 
      Furthermore, smoothed plots suggested the nonlinear relationships between serum 
      selenium and MCHC, hemoglobin level, and risk of anemia. Interestingly, on the 
      left of inflection point, serum selenium was associated with decreased risk of 
      anemia (OR = 0.972, 95%CI: 0.960, 0.985, p < .001), and then, the risk of anemia 
      increased with increasing serum selenium concentration (OR = 1.011, 95%CI: 1.002, 
      1.021, p = .023). Future large-scale, polycentric prospective studies should be 
      conducted to verify our results.
CI  - (c) 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
FAU - Zhou, Qing
AU  - Zhou Q
AD  - Central Laboratory People's Hospital of Baoan District The Second Affiliated 
      Hospital of Shenzhen University Shenzhen China.
FAU - Zhang, Baozhu
AU  - Zhang B
AD  - Department of Oncology People's Hospital of Baoan District The Second Affiliated 
      Hospital of Shenzhen University Shenzhen China.
FAU - Chen, Xi
AU  - Chen X
AD  - Central Laboratory People's Hospital of Baoan District The Second Affiliated 
      Hospital of Shenzhen University Shenzhen China.
FAU - Chen, Qiuyan
AU  - Chen Q
AD  - Science and Education Department Shenzhen Baoan Shiyan People's Hospital Shenzhen 
      China.
FAU - Hao, Lu
AU  - Hao L
AUID- ORCID: 0000-0002-4305-7766
AD  - Science and Education Department Shenzhen Baoan Shiyan People's Hospital Shenzhen 
      China.
LA  - eng
SI  - Dryad/10.5061/dryad.d5h62
PT  - Journal Article
DEP - 20210327
PL  - United States
TA  - Food Sci Nutr
JT  - Food science & nutrition
JID - 101605473
PMC - PMC8194763
OTO - NOTNLM
OT  - Selenium
OT  - anemia
OT  - cross-sectional study
OT  - hemoglobin concentrations
COIS- The authors declare that they do not have any conflict of interest Data 
      availability statement.
EDAT- 2021/06/18 06:00
MHDA- 2021/06/18 06:01
PMCR- 2021/03/27
CRDT- 2021/06/17 06:44
PHST- 2021/01/23 00:00 [received]
PHST- 2021/03/09 00:00 [revised]
PHST- 2021/03/14 00:00 [accepted]
PHST- 2021/06/17 06:44 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/06/18 06:01 [medline]
PHST- 2021/03/27 00:00 [pmc-release]
AID - FSN32261 [pii]
AID - 10.1002/fsn3.2261 [doi]
PST - epublish
SO  - Food Sci Nutr. 2021 Mar 27;9(6):3039-3047. doi: 10.1002/fsn3.2261. eCollection 
      2021 Jun.