PMID- 34136201
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2048-7177 (Print)
IS  - 2048-7177 (Electronic)
IS  - 2048-7177 (Linking)
VI  - 9
IP  - 6
DP  - 2021 Jun
TI  - Nephroprotective activity of natural products against chemical toxicants: The 
      role of Nrf2/ARE signaling pathway.
PG  - 3362-3384
LID - 10.1002/fsn3.2320 [doi]
AB  - Nephropathy can occur following exposure of the kidneys to oxidative stress. 
      Oxidative stress is the result of reactive oxygen species (ROS) formation due to 
      intracellular catabolism or exogenous toxicant exposure. Many natural products 
      (NPs) with antioxidant properties have been used to demonstrate that oxidative 
      damage-induced nephrotoxicity can be ameliorated or at least reduced through 
      stimulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling 
      pathway. Nrf2 is a basic leucine zipper (bZip) transcription factor that 
      regulates gene expression of the antioxidant response elements (ARE). Nrf2 is 
      involved in the cellular antioxidant-detoxification machinery. Nrf2 activation is 
      a major mechanism of nephroprotective activity for these NPs, which facilitates 
      its entry into the nucleus, primarily by inhibiting Kelch like-ECH-associated 
      protein 1 (Keap1). The purpose of this article was to review the peer-reviewed 
      literature of NPs that have shown mitigating effects on renal disorder by 
      stimulating Nrf2 and thereby suggesting potential new therapeutic or prophylactic 
      strategies against kidney-damaging xenobiotics.
CI  - (c) 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
FAU - Molaei, Emad
AU  - Molaei E
AD  - Faculty of Pharmacy Mashhad University of Medical Sciences Mashhad Iran.
FAU - Molaei, Ali
AU  - Molaei A
AD  - Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
FAU - Abedi, Farshad
AU  - Abedi F
AD  - Faculty of Pharmacy Mashhad University of Medical Sciences Mashhad Iran.
FAU - Hayes, A Wallace
AU  - Hayes AW
AD  - University of South Florida College of Public Health Tampa FL USA.
FAU - Karimi, Gholamreza
AU  - Karimi G
AUID- ORCID: 0000-0002-1273-5448
AD  - Pharmaceutical Research Center Institute of Pharmaceutical Technology Mashhad 
      University of Medical Sciences Mashhad Iran.
AD  - Department of Pharmacodynamics and Toxicology Faculty of Pharmacy Mashhad 
      University of Medical Sciences Mashhad Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210501
PL  - United States
TA  - Food Sci Nutr
JT  - Food science & nutrition
JID - 101605473
PMC - PMC8194945
OTO - NOTNLM
OT  - Nrf2
OT  - herbal medicine
OT  - natural products
OT  - nephroprotective
OT  - nephrotoxicity
OT  - xenobiotics
COIS- The authors declare no conflicts of interest.
EDAT- 2021/06/18 06:00
MHDA- 2021/06/18 06:01
PMCR- 2021/05/01
CRDT- 2021/06/17 06:44
PHST- 2021/02/01 00:00 [received]
PHST- 2021/04/15 00:00 [revised]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/06/17 06:44 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/06/18 06:01 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - FSN32320 [pii]
AID - 10.1002/fsn3.2320 [doi]
PST - epublish
SO  - Food Sci Nutr. 2021 May 1;9(6):3362-3384. doi: 10.1002/fsn3.2320. eCollection 
      2021 Jun.