PMID- 34136507
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210619
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Intrauterine Growth Restriction Promotes Postnatal Airway Hyperresponsiveness 
      Independent of Allergic Disease.
PG  - 674324
LID - 10.3389/fmed.2021.674324 [doi]
LID - 674324
AB  - Introduction: Intrauterine growth restriction (IUGR) is associated with asthma. 
      Murine models of IUGR have altered airway responsiveness in the absence of any 
      inflammatory exposure. Given that a primary feature of asthma is airway 
      inflammation, IUGR-affected individuals may develop more substantial respiratory 
      impairment if subsequently exposed to an allergen. This study used a maternal 
      hypoxia-induced mouse model of IUGR to determine the combined effects of IUGR and 
      allergy on airway responsiveness. Methods: Pregnant BALB/c mice were housed under 
      hypoxic conditions (10.5% O(2)) from gestational day (GD) 11-GD 17.5 (IUGR group; 
      term = GD 21). Following hypoxic exposure, mice were returned to a normoxic 
      environment (21% O(2)). A second group of pregnant mice were housed under 
      normoxic conditions throughout pregnancy (Control). All offspring were sensitized 
      to ovalbumin (OVA) and assigned to one of four treatment groups: Control - 
      normoxic and saline challenge; IUGR - hypoxic and saline challenge; Allergy - 
      normoxic and OVA challenge; and IUGR + Allergy - hypoxic and OVA challenge. At 8 
      weeks of age, and 24 h post-aerosol challenge, mice were tracheostomised for 
      methacholine challenge and assessment of lung mechanics by the forced oscillation 
      technique, and lungs subsequently fixed for morphometry. Results: IUGR offspring 
      were lighter than Control at birth and in adulthood. Both Allergy and IUGR 
      independently increased airway resistance after methacholine challenge. The IUGR 
      group also exhibited an exaggerated increase in tissue damping and elastance 
      after methacholine challenge compared with Control. However, there was no 
      incremental effect on airway responsiveness in the combined IUGR + Allergy group. 
      There was no impact of IUGR or Allergy on airway structure and no effect of sex 
      on any outcome. Conclusion: IUGR and aeroallergen independently increased 
      bronchoconstrictor response, but when combined the pathophysiology was not 
      worsened. Findings suggest that an association between IUGR and asthma is 
      mediated by baseline airway responsiveness rather than susceptibility to 
      allergen.
CI  - Copyright (c) 2021 Kalotas, Wang, Noble and Wang.
FAU - Kalotas, Jack O
AU  - Kalotas JO
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA, 
      Australia.
FAU - Wang, Carolyn J
AU  - Wang CJ
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA, 
      Australia.
FAU - Noble, Peter B
AU  - Noble PB
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA, 
      Australia.
FAU - Wang, Kimberley C W
AU  - Wang KCW
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA, 
      Australia.
AD  - Telethon Kids Institute, The University of Western Australia, Nedlands, WA, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20210531
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8200568
OTO - NOTNLM
OT  - airway hyperresponsiveness
OT  - allergy
OT  - asthma
OT  - intrauterine growth restriction
OT  - lung function
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/06/18 06:00
MHDA- 2021/06/18 06:01
PMCR- 2021/05/31
CRDT- 2021/06/17 06:48
PHST- 2021/03/01 00:00 [received]
PHST- 2021/05/07 00:00 [accepted]
PHST- 2021/06/17 06:48 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/06/18 06:01 [medline]
PHST- 2021/05/31 00:00 [pmc-release]
AID - 10.3389/fmed.2021.674324 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 May 31;8:674324. doi: 10.3389/fmed.2021.674324. 
      eCollection 2021.