PMID- 34136721
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 2451-9936 (Electronic)
IS  - 2451-9936 (Linking)
VI  - 23
DP  - 2021 Sep
TI  - Polypoidal choroidal vasculopathy in a case of retinitis pigmentosa, successfully 
      treated with intravitreal aflibercept.
PG  - 101123
LID - 10.1016/j.ajoc.2021.101123 [doi]
LID - 101123
AB  - PURPOSE: Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related 
      macular degeneration that is seen frequently in Asians. Nevertheless, it is rare 
      for this condition to be combined with retinitis pigmentosa (RP). The purpose of 
      this paper is to present findings from this rare combination in a Japanese 
      patient, and to describe its successful treatment with intravitreal aflibercept 
      (IVA). OBSERVATIONS: The patient was a 71-year-old Japanese woman with RP 
      (diagnosed at the age of 30) and PCV. She noticed a decrease in vision in her 
      right eye 6 months previously. Decimal best-corrected visual acuity (BCVA) was 
      0.05 in her right eye. Optical coherence tomography and indocyanine green 
      angiography (IA) revealed serous retinal detachment (SRD) and PCV in her right 
      eye. The SRD was initially resolved after 3 monthly treatments with IVA, but 
      recurrences began 5 months later, requiring four more treatments with IVA, 
      performed about every 4 months within the next 12 months, for successful 
      resolution. There were no recurrences of PCV in 7 more months of follow-up, as 
      confirmed with IA at the final appointment. Final decimal BCVA in the right eye 
      improved to 0.15. Furthermore, macular retinal sensitivity, measured with 
      microperimetry, increased after the treatment, and RP-related visual field 
      narrowing, determined by Goldmann perimetry, did not progress throughout follow 
      up of 26 months. CONCLUSION: More than 2 years of follow up showed that IVA may 
      be effective for treating PCV, even in RP patients, and can increase central 
      visual function without causing progression of RP-related visual field narrowing.
CI  - (c) 2021 Published by Elsevier Inc.
FAU - Takahashi, Nana
AU  - Takahashi N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Japan.
FAU - Kunikata, Hiroshi
AU  - Kunikata H
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Japan.
AD  - Department of Retinal Disease Control, Tohoku University Graduate School of 
      Medicine, Japan.
FAU - Yasuda, Masayuki
AU  - Yasuda M
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Japan.
FAU - Hariya, Takehiro
AU  - Hariya T
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Japan.
FAU - Nishiguchi, Koji M
AU  - Nishiguchi KM
AD  - Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of 
      Medicine, Japan.
FAU - Nakazawa, Toru
AU  - Nakazawa T
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Japan.
AD  - Department of Retinal Disease Control, Tohoku University Graduate School of 
      Medicine, Japan.
AD  - Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of 
      Medicine, Japan.
AD  - Department of Ophthalmic Imaging and Information Analytics, Tohoku University 
      Graduate School of Medicine, Japan.
LA  - eng
PT  - Case Reports
DEP - 20210524
PL  - United States
TA  - Am J Ophthalmol Case Rep
JT  - American journal of ophthalmology case reports
JID - 101679941
PMC - PMC8181791
OTO - NOTNLM
OT  - LSFG
OT  - Laser speckle flowgraphy
OT  - MP-3
OT  - Microperimetry
OT  - Vascular endothelial growth factor
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/06/18 06:00
MHDA- 2021/06/18 06:01
PMCR- 2021/05/24
CRDT- 2021/06/17 06:51
PHST- 2020/06/10 00:00 [received]
PHST- 2021/01/16 00:00 [revised]
PHST- 2021/05/10 00:00 [accepted]
PHST- 2021/06/17 06:51 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/06/18 06:01 [medline]
PHST- 2021/05/24 00:00 [pmc-release]
AID - S2451-9936(21)00132-8 [pii]
AID - 101123 [pii]
AID - 10.1016/j.ajoc.2021.101123 [doi]
PST - epublish
SO  - Am J Ophthalmol Case Rep. 2021 May 24;23:101123. doi: 10.1016/j.ajoc.2021.101123. 
      eCollection 2021 Sep.