PMID- 34137242
OWN - NLM
STAT- MEDLINE
DCOM- 20220804
LR  - 20220804
IS  - 2724-5772 (Electronic)
IS  - 2724-5683 (Linking)
VI  - 70
IP  - 4
DP  - 2022 Aug
TI  - Additive prognosis of clinical presentation in revascularized peripheral arterial 
      disease patients.
PG  - 413-420
LID - 10.23736/S2724-5683.21.05704-5 [doi]
AB  - BACKGROUND: Peripheral artery disease (PAD) is a frequent cause of morbidity and 
      mortality. It may present with diverse clinical presentations. The aim of this 
      study was to evaluate the prognosis of these clinical presentations. METHODS: We 
      performed a retrospective cohort study, in which symptomatic PAD patients were 
      included from 2014 to 2020 at a university hospital in Argentina. We classified 
      symptomatic PAD in intermittent claudication (IC), chronic limb-threatening 
      ischemia (CLTI) and acute ischemia (AI). Our primary endpoint was to compare the 
      composite of all-cause mortality and major amputation events between the three 
      groups. RESULTS: We included 309 patients, with a median follow up of 1.87 years 
      (IQR 0.72-3.67). The primary endpoint was more prevalent in CLTI and AI patients 
      (33% and 33.3%) compared to IC patients (8.1%), P<0.001. CLTI and AI were 
      independently associated with the primary endpoint after adjusting for clinical 
      variables of interest (OR 4.04 95%CI [1.86-9.07], P<0.001 and OR 5.40 95%CI 
      [2.18-13.7], P<0.001, respectively). Mortality incidence rate (per 100 
      patients/year) was similar between AI and CLTI patients (14.2 95% CI [8.0-24.1] 
      and 13.1 95%CI [8.8-19.7], respectively, P=0.67) but higher compared to IC (2.9 
      95%CI [1.6-5.1], P<0.01). Major amputation events were more prevalent in CLTI 
      (16.5%) compared to AI (8.9%) and IC patients (1.2%), P<0.01. CONCLUSIONS: Those 
      with CLTI and AI have a particular increased risk of all-cause death and major 
      amputation events. Although mortality incidence was similar between AI and CLTI 
      patients, the latter have an increased risk of major amputation events compared 
      to AI and IC patients.
FAU - Garagoli, Fernando
AU  - Garagoli F
AD  - Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, 
      Argentina - fernando.garagoli@hospitalitaliano.org.ar.
FAU - Chiabrando, Juan G
AU  - Chiabrando JG
AD  - Department of Interventional Cardiology, Hospital Italiano de Buenos Aires, 
      Buenos Aires, Argentina.
FAU - Abraham Foscolo, Maria M
AU  - Abraham Foscolo MM
AD  - Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Corna, Giuliana
AU  - Corna G
AD  - Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Fleitas, Maria M
AU  - Fleitas MM
AD  - Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, 
      Argentina.
FAU - Valle Raleigh, Juan
AU  - Valle Raleigh J
AD  - Department of Interventional Cardiology, Hospital Italiano de Buenos Aires, 
      Buenos Aires, Argentina.
FAU - Medina DE Chazal, Horacio
AU  - Medina DE Chazal H
AD  - Department of Interventional Cardiology, Hospital Italiano de Buenos Aires, 
      Buenos Aires, Argentina.
FAU - Chas, Jose G
AU  - Chas JG
AD  - Department of Digital Angiography, Hospital Italiano de Buenos Aires, Buenos 
      Aires, Argentina.
FAU - Berrocal, Daniel H
AU  - Berrocal DH
AD  - Department of Interventional Cardiology, Hospital Italiano de Buenos Aires, 
      Buenos Aires, Argentina.
FAU - Rabellino, Jose M
AU  - Rabellino JM
AD  - Department of Digital Angiography, Hospital Italiano de Buenos Aires, Buenos 
      Aires, Argentina.
FAU - Bluro, Ignacio M
AU  - Bluro IM
AD  - Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, 
      Argentina.
LA  - eng
PT  - Journal Article
DEP - 20210617
PL  - Italy
TA  - Minerva Cardiol Angiol
JT  - Minerva cardiology and angiology
JID - 101776555
SB  - IM
MH  - Humans
MH  - Intermittent Claudication/epidemiology/surgery
MH  - Ischemia/surgery
MH  - *Peripheral Arterial Disease/epidemiology/surgery
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2021/06/18 06:00
MHDA- 2022/08/05 06:00
CRDT- 2021/06/17 07:32
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2022/08/05 06:00 [medline]
PHST- 2021/06/17 07:32 [entrez]
AID - S2724-5683.21.05704-5 [pii]
AID - 10.23736/S2724-5683.21.05704-5 [doi]
PST - ppublish
SO  - Minerva Cardiol Angiol. 2022 Aug;70(4):413-420. doi: 
      10.23736/S2724-5683.21.05704-5. Epub 2021 Jun 17.