PMID- 34138868
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 6
DP  - 2021
TI  - Enhanced virulence of Plasmodium falciparum in blood of diabetic patients.
PG  - e0249666
LID - 10.1371/journal.pone.0249666 [doi]
LID - e0249666
AB  - Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued 
      malaria transmission, has resulted more patients dealing with both communicable 
      and non-communicable diseases. We previously reported that travelers with type 2 
      diabetes mellitus (T2DM) infected with Plasmodium falciparum were three times 
      more likely to develop severe malaria than non-diabetics. Here we explore the 
      biological basis for this by testing blood from uninfected subjects with type 1 
      and type 2 diabetes, ex vivo, for their effects on parasite growth and rosetting 
      (binding of infected erythrocytes to uninfected erythrocytes). Rosetting was 
      associated with type 2 diabetes, blood glucose and erythrocyte sedimentation rate 
      (ESR), while parasite growth was positively associated with blood glucose, 
      glycated hemoglobin (HbA1c), body mass index (BMI), fibrinogen and triglycerides. 
      This study establishes a link between diabetes and malaria virulence assays, 
      potentially explaining the protective effect of good glycemic control against 
      severe malaria in subjects with diabetes.
FAU - Ch'ng, Jun-Hong
AU  - Ch'ng JH
AD  - Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 
      Stockholm, Sweden.
AD  - Department of Microbiology and Immunology, National University of Singapore, 
      Singapore, Singapore.
FAU - Moll, Kirsten
AU  - Moll K
AD  - Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 
      Stockholm, Sweden.
FAU - Wyss, Katja
AU  - Wyss K
AD  - Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Infectious Diseases, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Hammar, Ulf
AU  - Hammar U
AD  - Department of Epidemiology, Institute for Environmental Medicine, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Ryden, Mikael
AU  - Ryden M
AD  - Department of Medicine Huddinge, Stockholm, Sweden.
AD  - Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
FAU - Kampe, Olle
AU  - Kampe O
AD  - Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
FAU - Farnert, Anna
AU  - Farnert A
AD  - Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Infectious Diseases, Karolinska University Hospital, Stockholm, 
      Sweden.
FAU - Wahlgren, Mats
AU  - Wahlgren M
AUID- ORCID: 0000-0001-6541-6056
AD  - Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 
      Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210617
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Diabetes Mellitus, Type 1/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Plasmodium falciparum/*pathogenicity
MH  - Virulence
PMC - PMC8211161
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/06/18 06:00
MHDA- 2023/02/25 06:00
PMCR- 2021/06/17
CRDT- 2021/06/17 17:24
PHST- 2020/10/04 00:00 [received]
PHST- 2021/03/22 00:00 [accepted]
PHST- 2021/06/17 17:24 [entrez]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2021/06/17 00:00 [pmc-release]
AID - PONE-D-20-31196 [pii]
AID - 10.1371/journal.pone.0249666 [doi]
PST - epublish
SO  - PLoS One. 2021 Jun 17;16(6):e0249666. doi: 10.1371/journal.pone.0249666. 
      eCollection 2021.