PMID- 34139296
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 166
DP  - 2021 Nov 1
TI  - Inflammatory cytokines and appetite in older hospitalized patients.
PG  - 105470
LID - S0195-6663(21)00377-9 [pii]
LID - 10.1016/j.appet.2021.105470 [doi]
AB  - It has already been confirmed that the decline in appetite during disease is a 
      common issue and the biologic players of inflammation such as cytokines may serve 
      as mediators of this effect. This study aimed to investigate the association of 
      appetite with individual cytokines that could be involved in the 
      inflammation-associated loss of appetite in acutely ill older hospitalized 
      patients. 191 patients (mean age 81.3 +/- 6.6 years, 64% women) participated in 
      this prospective observational study. Risk of malnutrition and patient's appetite 
      were evaluated using the Mini Nutritional Assessment Short Form and the 
      Simplified Nutritional Appetite Questionnaire on admission, respectively. Serum 
      C-reactive protein (CRP) and serum cytokines such as Interleukin 1 beta (IL-1beta), 
      IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, interferon alpha-2, 
      interferon gamma, tumor necrosis factor alpha and monocyte chemoattractant 
      protein-1 (MCP-1) were measured. Of total population, 30% had CRP>3.0 (mg/dL), 
      31% were malnourished and 31% demonstrated poor and very poor appetite. There 
      were significant differences in the mean concentrations of a number of cytokines 
      including IL-1beta, MCP-1, IL-6, IL-10, IL-12p70, IL-18 and IL-23 across the 
      appetite scores. In a regression analysis, an increased IL-18 level (P = 0.049) 
      was the most prominent biomarker for poor appetite. No other significant 
      associations between appetite and circulating levels of other cytokines were 
      found in the regression analysis, except for IL-6 and IL-33, which were only 
      significantly associated in the unadjusted model. The association of IL-18 with 
      decreased appetite was independent from the severity of CRP-level and infections. 
      In this study, certain cytokines, in particular IL-18 were associated with poor 
      appetite in acutely diseased patients and should therefore be considered as a 
      potential target of the prevention and treatment of malnutrition.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Pourhassan, Maryam
AU  - Pourhassan M
AD  - Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universitat Bochum, 
      Germany. Electronic address: maryam.pourhassan@ruhr-uni-bochum.de.
FAU - Babel, Nina
AU  - Babel N
AD  - Medical Department I, General Internal Medicine, Marien Hospital Herne, 
      Ruhr-Universitat Bochum, Germany.
FAU - Sieske, Lars
AU  - Sieske L
AD  - Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universitat Bochum, 
      Germany.
FAU - Westhoff, Timm Henning
AU  - Westhoff TH
AD  - Medical Department I, General Internal Medicine, Marien Hospital Herne, 
      Ruhr-Universitat Bochum, Germany.
FAU - Wirth, Rainer
AU  - Wirth R
AD  - Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universitat Bochum, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210615
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
RN  - 0 (Cytokines)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Appetite
MH  - C-Reactive Protein
MH  - Cytokines
MH  - Female
MH  - Humans
MH  - Male
MH  - *Malnutrition
MH  - Nutrition Assessment
OTO - NOTNLM
OT  - Appetite
OT  - C-reactive protein
OT  - Cytokines
OT  - Inflammation
OT  - Interleukin-18
OT  - Older persons
EDAT- 2021/06/18 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/06/17 20:12
PHST- 2021/01/08 00:00 [received]
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/06/11 00:00 [accepted]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2021/06/17 20:12 [entrez]
AID - S0195-6663(21)00377-9 [pii]
AID - 10.1016/j.appet.2021.105470 [doi]
PST - ppublish
SO  - Appetite. 2021 Nov 1;166:105470. doi: 10.1016/j.appet.2021.105470. Epub 2021 Jun 
      15.