PMID- 34139432
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20240402
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 68
DP  - 2021 Jun
TI  - Maternal fecal microbiome predicts gestational age, birth weight and neonatal 
      growth in rural Zimbabwe.
PG  - 103421
LID - S2352-3964(21)00214-0 [pii]
LID - 10.1016/j.ebiom.2021.103421 [doi]
LID - 103421
AB  - BACKGROUND: Preterm birth and low birth weight (LBW) affect one in ten and one in 
      seven livebirths, respectively, primarily in low-income and middle-income 
      countries (LMIC) and are major predictors of poor child health outcomes. However, 
      both have been recalcitrant to public health intervention. The maternal 
      intestinal microbiome may undergo substantial changes during pregnancy and may 
      influence fetal and neonatal health in LMIC populations. METHODS: Within a 
      subgroup of 207 mothers and infants enrolled in the SHINE trial in rural 
      Zimbabwe, we performed shotgun metagenomics on 351 fecal specimens provided 
      during pregnancy and at 1-month post-partum to investigate the relationship 
      between the pregnancy gut microbiome and infant gestational age, birth weight, 
      1-month length-, and weight-for-age z-scores using extreme gradient boosting 
      machines. FINDINGS: Pregnancy gut microbiome taxa and metabolic functions 
      predicted birth weight and WAZ at 1 month more accurately than gestational age 
      and LAZ. Blastoscystis sp, Brachyspira sp and Treponeme carriage were high 
      compared to Western populations. Resistant starch-degraders were important 
      predictors of birth outcomes. Microbiome capacity for environmental sensing, 
      vitamin B metabolism, and signalling predicted increased infant birth weight and 
      neonatal growth; while functions involved in biofilm formation in response to 
      nutrient starvation predicted reduced birth weight and growth. INTERPRETATION: 
      The pregnancy gut microbiome in rural Zimbabwe is characterized by resistant 
      starch-degraders and may be an important metabolic target to improve birth 
      weight. FUNDING: Bill and Melinda Gates Foundation, UK Department for 
      International Development, Wellcome Trust, Swiss Agency for Development and 
      Cooperation, US National Institutes of Health, and UNICEF.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Gough, Ethan K
AU  - Gough EK
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA. Electronic address: amee.manges@ubc.ca.
FAU - Edens, Thaddeus J
AU  - Edens TJ
AD  - Devil's Staircase Consulting, West Vancouver, British Columbia, Canada.
FAU - Geum, Hyun Min
AU  - Geum HM
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, Canada.
FAU - Baharmand, Iman
AU  - Baharmand I
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, Canada.
FAU - Gill, Sandeep K
AU  - Gill SK
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, Canada.
FAU - Robertson, Ruairi C
AU  - Robertson RC
AD  - Blizard Institute, Queen Mary University of London, London, UK.
FAU - Mutasa, Kuda
AU  - Mutasa K
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Ntozini, Robert
AU  - Ntozini R
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Smith, Laura E
AU  - Smith LE
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; 
      Department of Population Medicine and Diagnostics, Cornell University, Ithaca, 
      NY, USA.
FAU - Chasekwa, Bernard
AU  - Chasekwa B
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Majo, Florence D
AU  - Majo FD
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Tavengwa, Naume V
AU  - Tavengwa NV
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Mutasa, Batsirai
AU  - Mutasa B
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Francis, Freddy
AU  - Francis F
AD  - Department of Experimental Medicine, University of British Columbia, Canada.
FAU - Carr, Lynnea
AU  - Carr L
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Canada.
FAU - Tome, Joice
AU  - Tome J
AD  - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
FAU - Stoltzfus, Rebecca J
AU  - Stoltzfus RJ
AD  - Goshen College, Goshen, Indiana, USA.
FAU - Moulton, Lawrence H
AU  - Moulton LH
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA.
FAU - Prendergast, Andrew J
AU  - Prendergast AJ
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA; Blizard Institute, Queen Mary University of London, 
      London, UK; Zvitambo Institute for Maternal and Child Health Research, Harare, 
      Zimbabwe.
FAU - Humphrey, Jean H
AU  - Humphrey JH
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA; Blizard Institute, Queen Mary University of London, 
      London, UK.
FAU - Manges, Amee R
AU  - Manges AR
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, Canada; British Columbia Centre for Disease Control, Vancouver, 
      British Columbia, Canada.
FAU - Team, Shine Trial
AU  - Team ST
AD  - Members of the SHINE Trial team who are not named authors are listed in 
      https://academic.oup.com/cid/article/61/suppl_7/S685/358186.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 206455/Z/17/Z/WT_/Wellcome Trust/United Kingdom
GR  - R01 HD060338/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20210615
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (RNA, Ribosomal, 16S)
SB  - IM
CIN - EBioMedicine. 2021 Jul;69:103449. PMID: 34157483
MH  - Bacteria/*classification/genetics/isolation & purification
MH  - *Birth Weight
MH  - *Body Height
MH  - Child Development
MH  - Feces/*microbiology
MH  - Female
MH  - Gestational Age
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Metagenomics/*methods
MH  - Mothers
MH  - Pregnancy
MH  - RNA, Ribosomal, 16S/*genetics
MH  - Randomized Controlled Trials as Topic
MH  - Rural Population
MH  - Sequence Analysis, DNA
MH  - Zimbabwe
PMC - PMC8217692
OTO - NOTNLM
OT  - birth weight
OT  - gestation
OT  - maternal
OT  - metagenome
OT  - microbiome
OT  - pregnancy
COIS- Declaration of Competing Interest None.
EDAT- 2021/06/18 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/06/15
CRDT- 2021/06/17 20:16
PHST- 2020/12/21 00:00 [received]
PHST- 2021/05/14 00:00 [revised]
PHST- 2021/05/17 00:00 [accepted]
PHST- 2021/06/18 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/06/17 20:16 [entrez]
PHST- 2021/06/15 00:00 [pmc-release]
AID - S2352-3964(21)00214-0 [pii]
AID - 103421 [pii]
AID - 10.1016/j.ebiom.2021.103421 [doi]
PST - ppublish
SO  - EBioMedicine. 2021 Jun;68:103421. doi: 10.1016/j.ebiom.2021.103421. Epub 2021 Jun 
      15.