PMID- 34140784
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 1178-6973 (Print)
IS  - 1178-6973 (Electronic)
IS  - 1178-6973 (Linking)
VI  - 14
DP  - 2021
TI  - Microbial Spectrum and Resistance Patterns in Ocular Infections: A 15-Year Review 
      in East China.
PG  - 2165-2171
LID - 10.2147/IDR.S314647 [doi]
AB  - PURPOSE: To report antibiotic resistance rates and trends of common ocular 
      isolates collected over a 15-year period. METHODS: We collected 3533 isolates 
      from July 1, 2005 to July 31, 2020. Antibiotic sensitivity was determined 
      according to the guidelines of the Clinical and Laboratory Standards Institute. 
      Chi-squared (chi (2)) test was used to analyze changes in antibiotic susceptibility 
      over 15 years. RESULTS: Among the 3533 isolates, the predominant pathogens were 
      the staphylococcal species. Methicillin resistance was observed in 381 
      Staphylococcus aureus (S. aureus) isolates (46.4%) and 1888 coagulase-negative 
      staphylococci (CoNS) isolates (61.1%), and methicillin-resistant (MR) isolates 
      had a high probability of concurrent resistance to fluoroquinolones and 
      aminoglycosides. The mean percentage of resistance in staphylococcal isolates did 
      not reach statistical significance across patient age groups (P = 0.87). 
      Methicillin resistance did not increase in the CoNS (P = 0.546) isolates, and 
      resistance to methicillin slightly decreased among S. aureus (P = 0.04) isolates 
      over 15 years. Additional exploratory analysis revealed a small decrease in 
      resistance to tobramycin (P = 0.01) and chloramphenicol (P < 0.001) among the 
      CoNS isolates. All staphylococcal isolates were susceptible to vancomycin. 
      CONCLUSION: Staphylococci were the most common microorganisms responsible for 
      causing ocular infections. Antibiotic resistance was high among staphylococci, 
      with nearly half of these isolates were resistant to methicillin and these had a 
      high probability of concurrent resistance among MR staphylococci to other 
      antibiotics. Overall, ocular resistance did not significantly change during the 
      15-year study period. We conclude that continued surveillance of antibiotic 
      resistance provides critical data to guide antibiotic selection.
CI  - (c) 2021 Liu et al.
FAU - Liu, Chunhong
AU  - Liu C
AD  - Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, People's 
      Republic of China.
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, People's Republic of China.
FAU - Ding, Baixing
AU  - Ding B
AD  - Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's 
      Republic of China.
FAU - Ji, Jian
AU  - Ji J
AD  - Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, People's 
      Republic of China.
FAU - Wang, Zhujian
AU  - Wang Z
AD  - Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, People's 
      Republic of China.
FAU - Chen, Huiwen
AU  - Chen H
AD  - Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, People's 
      Republic of China.
FAU - Cao, Wenjun
AU  - Cao W
AD  - Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, People's 
      Republic of China.
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210610
PL  - New Zealand
TA  - Infect Drug Resist
JT  - Infection and drug resistance
JID - 101550216
PMC - PMC8203601
OTO - NOTNLM
OT  - antibiotic resistance
OT  - methicillin
OT  - ocular isolate
OT  - staphylococci
COIS- The sponsor or funding organization had no role in the design or conduct of this 
      research. No conflicting relationships exists for any author.
EDAT- 2021/06/19 06:00
MHDA- 2021/06/19 06:01
PMCR- 2021/06/10
CRDT- 2021/06/18 06:40
PHST- 2021/04/07 00:00 [received]
PHST- 2021/05/18 00:00 [accepted]
PHST- 2021/06/18 06:40 [entrez]
PHST- 2021/06/19 06:00 [pubmed]
PHST- 2021/06/19 06:01 [medline]
PHST- 2021/06/10 00:00 [pmc-release]
AID - 314647 [pii]
AID - 10.2147/IDR.S314647 [doi]
PST - epublish
SO  - Infect Drug Resist. 2021 Jun 10;14:2165-2171. doi: 10.2147/IDR.S314647. 
      eCollection 2021.