PMID- 34143688
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220716
IS  - 2151-3228 (Electronic)
IS  - 2151-321X (Print)
IS  - 2151-321X (Linking)
VI  - 34
IP  - 2
DP  - 2021 Jun
TI  - Paracetamol Allergy: A Case of a 9-Year-Old Female with a History of Atopy.
PG  - 80-82
LID - 10.1089/ped.2021.0027 [doi]
AB  - Background: We describe a rare case involving paracetamol, a commonly used drug 
      worldwide. Increased paracetamol consumption increases the risk of adverse drug 
      reactions. Case Presentation: This is a case of a 9-year-old girl who visited the 
      emergency department due to sudden onset sneezing, nasal itching, urticaria, and 
      angioedema after paracetamol ingestion. The diagnostic and etiologic studies 
      revealed an immunoglobulin E (IgE)-mediated hypersensitivity mechanism to 
      paracetamol. Conclusion: Few cases of this phenomenon have been reported in 
      previous literature. As confirmed in this study, a negative skin prick test did 
      not exclude hypersensitivity, and conducting intradermal tests (IDTs) increased 
      diagnostic accuracy. The patient had a positive IDT, confirming the underlying 
      IgE-mediated reaction. The follow-up of a confirmed paracetamol hypersensitivity 
      implies patient education about avoidance of any paracetamol-containing 
      formulation, including combination products and clarification of available 
      alternative drugs. This is likely the first publication documenting IgE-mediated 
      paracetamol allergy in pediatric patients. We intend to underline the clinical 
      benefits of diagnostic confirmation toward suspected drug hypersensitivity 
      reactions in children, a particularly useful topic for pediatricians and 
      pediatric allergists.
FAU - Teles, Ariana
AU  - Teles A
AUID- ORCID: 0000-0003-3745-4404
AD  - Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa 
      Luzia de Viana do Castelo, Viana do Castelo, Portugal.
FAU - Ribeiro-Mourao, Francisco
AU  - Ribeiro-Mourao F
AD  - Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa 
      Luzia de Viana do Castelo, Viana do Castelo, Portugal.
FAU - Branco, Mariana
AU  - Branco M
AD  - Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa 
      Luzia de Viana do Castelo, Viana do Castelo, Portugal.
FAU - Araujo, Ana Rita
AU  - Araujo AR
AD  - Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa 
      Luzia de Viana do Castelo, Viana do Castelo, Portugal.
FAU - Vieira, Teresa
AU  - Vieira T
AD  - Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa 
      Luzia de Viana do Castelo, Viana do Castelo, Portugal.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Allergy Immunol Pulmonol
JT  - Pediatric allergy, immunology, and pulmonology
JID - 101549629
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/adverse effects
MH  - Child
MH  - *Drug Hypersensitivity/diagnosis/etiology
MH  - Female
MH  - Humans
MH  - *Hypersensitivity, Immediate
MH  - Intradermal Tests
MH  - Skin Tests
PMC - PMC8329691
OTO - NOTNLM
OT  - adverse drug reactions
OT  - allergy
OT  - immunoglobulin E
OT  - intradermal tests
OT  - paracetamol
OT  - pediatric
COIS- No competing financial interests exist.
EDAT- 2021/06/19 06:00
MHDA- 2022/01/14 06:00
PMCR- 2022/06/01
CRDT- 2021/06/18 17:12
PHST- 2021/06/18 17:12 [entrez]
PHST- 2021/06/19 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.1089/ped.2021.0027 [pii]
AID - 10.1089/ped.2021.0027 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol Pulmonol. 2021 Jun;34(2):80-82. doi: 
      10.1089/ped.2021.0027.