PMID- 34143904
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20211117
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 102
IP  - 1
DP  - 2022 Jan 15
TI  - Monitoring residue levels and dietary risk assessment of thiamethoxam and its 
      metabolite clothianidin for Chinese consumption of Chinese kale.
PG  - 417-424
LID - 10.1002/jsfa.11371 [doi]
AB  - BACKGROUND: Thiamethoxam is widely used to control pests in Chinese kale, 
      popularly consumed leafy vegetables. The potential risk to the environment and 
      human health has aroused much public concern. Therefore, it is important to 
      investigate the degradation behavior, residue distribution and dietary risk 
      assessment of thiamethoxam in Chinese kale. RESULTS: A sensitive analytical 
      method for determination of thiamethoxam and its metabolite clothianidin residue 
      in Chinese kale was established and validated through a quick, easy, cheap, 
      effective, rugged, and safe (QuEChERS) technique with ultra-performance liquid 
      chromatography tandem mass spectrometry (UPLC-MS/MS). The recoveries were 
      85.4-101.2% for thiamethoxam and 79.5-108.1% for clothianidin, with the relative 
      standard deviations (RSDs) of 0.9-10.2% and 1.8-6.0%, respectively. For the 
      dissipation kinetics, the data showed that thiamethoxam in Chinese kale was 
      degraded with the half-lives of 4.1 to 4.5 days. In the terminal residue 
      experiments, the residues of thiamethoxam were 0.017-0.357 mg kg(-1) after 
      application 2-3 times with a preharvest interval (PHI) of 7 days under the 
      designed dosages. The chronic and acute dietary exposure assessment risk quotient 
      (RQ) values of thiamethoxam in Chinese kale for different Chinese consumers were 
      0.08-0.19% and 0.05-0.12%, respectively, and those of clothianidin were 
      0.01-0.04% and 0.02-0.04%, respectively, all of the RQ values were lower than 
      100%. CONCLUSION: Thiamethoxam in Chinese kale was rapidly degraded following 
      first-order kinetics models. The dietary risk of thiamethoxam and clothianidin 
      through Chinese kale was negligible to consumers. The results from this study are 
      important reference for Chinese governments to developing criteria for the safe 
      and rational use of thiamethoxam, setting maximum residue levels (MRLs), 
      monitoring the quality safety of agricultural products and protecting consumer 
      health. (c) 2021 Society of Chemical Industry.
CI  - (c) 2021 Society of Chemical Industry.
FAU - Li, Kai-Long
AU  - Li KL
AUID- ORCID: 0000-0003-2386-6897
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
FAU - Chen, Wu-Ying
AU  - Chen WY
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
FAU - Luo, Xiang-Wen
AU  - Luo XW
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
FAU - Zhang, De-Yong
AU  - Zhang DY
AUID- ORCID: 0000-0002-2239-0252
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
FAU - Chen, Ang
AU  - Chen A
AD  - Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, 
      Changsha, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20210628
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Guanidines)
RN  - 0 (Neonicotinoids)
RN  - 0 (Pesticide Residues)
RN  - 0 (Thiazoles)
RN  - 2V9906ABKQ (clothianidin)
RN  - 747IC8B487 (Thiamethoxam)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brassica/*chemistry/metabolism
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Chromatography, Liquid/*methods
MH  - Dietary Exposure/adverse effects/analysis
MH  - Female
MH  - Food Contamination/analysis
MH  - Guanidines/*metabolism
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - Neonicotinoids/*metabolism
MH  - Pesticide Residues/*chemistry/*metabolism
MH  - Risk Assessment
MH  - Tandem Mass Spectrometry/*methods
MH  - Thiamethoxam/*chemistry/*metabolism
MH  - Thiazoles/*metabolism
MH  - Vegetables/chemistry/metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Chinese kale
OT  - degradation
OT  - dietary risk assessment
OT  - residue distribution
OT  - thiamethoxam
EDAT- 2021/06/19 06:00
MHDA- 2021/11/18 06:00
CRDT- 2021/06/18 17:23
PHST- 2021/05/13 00:00 [revised]
PHST- 2021/01/24 00:00 [received]
PHST- 2021/06/18 00:00 [accepted]
PHST- 2021/06/19 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/06/18 17:23 [entrez]
AID - 10.1002/jsfa.11371 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2022 Jan 15;102(1):417-424. doi: 10.1002/jsfa.11371. Epub 2021 
      Jun 28.