PMID- 34144467
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220207
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 222
DP  - 2021 Sep
TI  - Two new lanthanide complexes with 5-(Pyrazol-1-yl)nicotinic acid: Structures and 
      their anti-cancer properties.
PG  - 111505
LID - S0162-0134(21)00152-5 [pii]
LID - 10.1016/j.jinorgbio.2021.111505 [doi]
AB  - Two new lanthanide complexes [PrL(2)(EA)(2)]NO(3) (complex 1) and 
      [SmL(2)(EA)(2)]NO(3) (complex 2) (H(2)L = 5-(Pyrazol-1-yl)nicotinic acid, 
      EA = CH(3)CH(2)OH) were synthesized. The structures were characterized by single 
      crystal X-ray and elemental analysis. The interaction between the complex and 
      fish sperm DNA(FS-DNA) was monitored using ultraviolet and fluorescence 
      spectroscopy, and the binding constants were determined. Both complexes showed 
      the ability to effectively bind DNA, and the molecular docking technology was 
      used to simulate the binding of the complex and DNA. In addition, through the 
      annexin V-Fluorescein Isothiocyanate(FITC)/ Propidium Iodide (PI) test 
      experiment, tetrazollium [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium 
      bromide(MTT) in vitro test, and cell morphology apoptosis studies, it was shown 
      that the complex can effectively induce HeLa tumor cell apoptosis. Compared with 
      cisplatin and complex, complex 1 shows significant cancer cell inhibition, and we 
      hope that this new type of complex will open up new ways for the next generation 
      of drugs in biomedical applications.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Zhu, Xiaopeng
AU  - Zhu X
AD  - International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and 
      Department of Coordination Chemistry, Shenyang University of Chemical Technology, 
      Shenyang 110142, PR China.
FAU - Li, Zhipeng
AU  - Li Z
AD  - International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and 
      Department of Coordination Chemistry, Shenyang University of Chemical Technology, 
      Shenyang 110142, PR China.
FAU - Ji, Xiaoxi
AU  - Ji X
AD  - International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and 
      Department of Coordination Chemistry, Shenyang University of Chemical Technology, 
      Shenyang 110142, PR China.
FAU - Chen, Qing
AU  - Chen Q
AD  - International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and 
      Department of Coordination Chemistry, Shenyang University of Chemical Technology, 
      Shenyang 110142, PR China.
FAU - Wu, Shuangyan
AU  - Wu S
AD  - International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and 
      Department of Coordination Chemistry, Shenyang University of Chemical Technology, 
      Shenyang 110142, PR China.
FAU - Gao, Enjun
AU  - Gao E
AD  - School of Chemical Engineering, University of Science and Technology Liaoning, 
      Anshan 114051, PR China.
FAU - Zhu, Mingchang
AU  - Zhu M
AD  - International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and 
      Department of Coordination Chemistry, Shenyang University of Chemical Technology, 
      Shenyang 110142, PR China; Key Laboratory of Resource Chemical Technology and 
      Materials, (Ministry of Education), Shenyang University Chemical Technology, 
      Shenyang 110142, PR China. Electronic address: mczhu@syuct.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210611
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Coordination Complexes)
RN  - 0 (Nicotinic Acids)
RN  - 0 (Pyrazoles)
RN  - 42OD65L39F (Samarium)
RN  - 9007-49-2 (DNA)
RN  - NKN7EZA750 (Praseodymium)
SB  - IM
MH  - Antineoplastic Agents/chemical synthesis/metabolism/*pharmacology
MH  - Apoptosis/drug effects
MH  - Coordination Complexes/chemical synthesis/metabolism/*pharmacology
MH  - DNA/metabolism
MH  - Drug Screening Assays, Antitumor
MH  - HeLa Cells
MH  - Humans
MH  - Molecular Docking Simulation
MH  - Molecular Structure
MH  - Nicotinic Acids/chemical synthesis/metabolism/*pharmacology
MH  - Praseodymium/chemistry
MH  - Pyrazoles/chemical synthesis/metabolism/*pharmacology
MH  - Samarium/chemistry
OTO - NOTNLM
OT  - AnnexinV-FITC/PI flow
OT  - Anti-cancer
OT  - Complexes
OT  - DNA binding
OT  - Lanthanides
OT  - MTT
EDAT- 2021/06/19 06:00
MHDA- 2022/02/08 06:00
CRDT- 2021/06/18 20:28
PHST- 2020/12/18 00:00 [received]
PHST- 2021/05/29 00:00 [revised]
PHST- 2021/05/30 00:00 [accepted]
PHST- 2021/06/19 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/06/18 20:28 [entrez]
AID - S0162-0134(21)00152-5 [pii]
AID - 10.1016/j.jinorgbio.2021.111505 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2021 Sep;222:111505. doi: 10.1016/j.jinorgbio.2021.111505. Epub 
      2021 Jun 11.