PMID- 34144912
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 18
IP  - 7
DP  - 2021 Jul
TI  - Minimal Clinically Important Difference (MCID) for the Pelvic Organ 
      Prolapse-Urinary Incontinence Sexual Function Questionnaire - IUGA Revised 
      (PISQ-IR).
PG  - 1265-1270
LID - S1743-6095(21)00428-8 [pii]
LID - 10.1016/j.jsxm.2021.04.005 [doi]
AB  - BACKGROUND: To put statistically significant changes in patient reported outcome 
      measurement (PROM) questionnaires into a clinical perspective, the concept of the 
      minimal clinically important difference (MCID) can be used. AIM: To determine the 
      MCID for the summary score for sexually active (SA) women of the Pelvic Organ 
      Prolapse/Urinary Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR), a 
      validated instrument which assesses sexual functioning (SF) for patients 
      suffering from a symptomatic pelvic floor disorder. METHODS: Patients 
      participating in a multicentre prospective cohort study comparing pessary therapy 
      with surgery for a symptomatic pelvic organ prolapse (POP) filled in the PISQ-IR 
      at baseline and 12 months' follow-up. We used both an anchor-based as well as a 
      distribution-based method to calculate the MCID for both treatment groups. The 
      Patient Global Impression of Improvement (PGI-I) questionnaire and PISQ-IR 
      question 19a about satisfaction with sexual functioning were used as anchors. For 
      the distribution-based approach we used the effect size (ES). OUTCOMES: MCID for 
      the SA summary score of the PISQ-IR. RESULTS: Data of 243 women were used to 
      calculate the MCID. In the pessary group, Kendall's tau-b correlation 
      coefficients between the PISQ-IR summary score and both anchors were below the 
      cut-off of 0.21, which implies the anchors cannot be used to calculate an MCID. 
      In our surgery group, the PISQ-IR question 19a met the anchor criteria and 0.31 
      points increase in the PISQ-IR summary score was equal to an improvement of 1 
      point on question 19a about satisfaction with sexual functioning. CLINICAL 
      IMPLICATIONS: Future research on this subject should focus on clinical relevance 
      of results rather than statistical significance only. STRENGTHS & LIMITATIONS: 
      Our main strength is the fact that we used both anchor-based and 
      distribution-based methods to determine our MCID. Secondly, we set out to 
      determine an MCID for both treatment groups separately, which relatively enhances 
      the generalisability of our results. A limitation is that we were not able to 
      estimate an MCID for the pessary group. Pruijssers B, van der Vaart L, Milani F, 
      et al. Minimal Clinically Important Difference (MCID) for the Pelvic Organ 
      Prolapse-Urinary Incontinence Sexual Function Questionnaire - IUGA Revised 
      (PISQ-IR). J Sex Med 2021;18:1265-1270. CONCLUSION: We estimated the MCID for the 
      PISQ-IR SA summary score to be 0.31 in our surgery group.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Pruijssers, Bente
AU  - Pruijssers B
AD  - Department of Obstetrics and Gynecology, University Medical Center, Utrecht, The 
      Netherlands. Electronic address: bentepruijssers@gmail.com.
FAU - van der Vaart, Lisa
AU  - van der Vaart L
AD  - Department of Gynecology and Obstetrics, Amsterdam University Medical Center, 
      Amsterdam, The Netherlands.
FAU - Milani, Fred
AU  - Milani F
AD  - Department of Obstetrics & Gynaecology, Reinier de Graaf Hospital, Delft, The 
      Netherlands.
FAU - Roovers, Jan-Paul
AU  - Roovers JP
AD  - Department of Gynecology and Obstetrics, Amsterdam University Medical Center, 
      Amsterdam, The Netherlands.
FAU - Vollebregt, Astrid
AU  - Vollebregt A
AD  - Department of Obstetrics and Gynaecology, Spaarne Gasthuis, Haarlem, The 
      Netherlands.
FAU - van der Vaart, Huub
AU  - van der Vaart H
AD  - Department of Obstetrics and Gynecology, University Medical Center, Utrecht, The 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210616
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
SB  - IM
MH  - Female
MH  - Humans
MH  - Minimal Clinically Important Difference
MH  - *Pelvic Organ Prolapse/therapy
MH  - Prospective Studies
MH  - Sexual Behavior
MH  - Surveys and Questionnaires
MH  - *Urinary Incontinence/therapy
OTO - NOTNLM
OT  - Female
OT  - Minimal Clinically Important Difference
OT  - Pelvic Organ Prolapse
OT  - Sexual Dysfunction
OT  - Surveys and questionnaires
OT  - Urinary Incontinence
EDAT- 2021/06/20 06:00
MHDA- 2021/07/29 06:00
CRDT- 2021/06/19 05:36
PHST- 2020/10/29 00:00 [received]
PHST- 2021/04/09 00:00 [revised]
PHST- 2021/04/12 00:00 [accepted]
PHST- 2021/06/20 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2021/06/19 05:36 [entrez]
AID - S1743-6095(21)00428-8 [pii]
AID - 10.1016/j.jsxm.2021.04.005 [doi]
PST - ppublish
SO  - J Sex Med. 2021 Jul;18(7):1265-1270. doi: 10.1016/j.jsxm.2021.04.005. Epub 2021 
      Jun 16.