PMID- 34146037
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210826
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 69
IP  - 7
DP  - 2021 Jul
TI  - Effect of myopia and optic disc area on ganglion cell-inner plexiform layer and 
      retinal nerve fiber layer thickness.
PG  - 1820-1824
LID - 10.4103/ijo.IJO_2818_20 [doi]
AB  - PURPOSE: The aim of this work was to study the impact of myopia and different 
      optic disc areas on ganglion cell-inner plexiform layer (GCIPL) and retinal nerve 
      fiber layer (RNFL) thickness profiles in myopic patients by spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: This was a cross-sectional study 
      of 100 eyes of 50 myopic individuals. All patients underwent complete ophthalmic 
      evaluation and SD-OCT examination. According to spherical equivalent (SE), 
      patients were divided into M1, M2, and M3 (low, moderate, and high myopia group). 
      According to optic disc area values, patients were divided into D1, D2 and D3 
      (small, medium and large disc groups). Average GCIPL and RNFL thickness recorded 
      globally and separately for all quadrants and also according to 12 clock hours 
      and analyzed with respect to different myopic groups, optic disc area groups, and 
      axial length. RESULTS: Quadrantic RNFL thickness profiles and their average RNFL 
      thickness were significantly thinner in high myopic group compared to low myopic 
      group, except for the temporal quadrant (P < 0.05). Average RNFL and RNFL 
      thickness of all quadrants were significantly thicker in the large disc group 
      than in the small disc group (P < 0.05). Average GCIPL and GCIPL thicknesses of 
      all sectors were significantly thinner in high myopic group compared to low 
      myopic group (P < 0.05). No significant correlation was observed between GCIPL 
      and disc area changes. Average RNFL thickness correlated significantly with SE 
      (3.667 mum/diopter), axial length (-5.3805 mum/mm) and optic disc area (9.4617 
      mum/mm(2)). Also, average GCIPL thickness correlated statistically significantly 
      with SE (1.6807 mum/diopter) and axial length (-2.626 mum/mm). CONCLUSION: Myopia 
      and axial length significantly reduce RNFL and GCIPL thickness profiles but the 
      optic disc area significantly increases RNFL thickness, but not GCIPL thickness.
FAU - Ganekal, Sunil
AU  - Ganekal S
AD  - Department of Ophthalmology, JJM Medical College, Davangere, Karnataka, India.
FAU - Sadhwini, M H
AU  - Sadhwini MH
AD  - Department of Ophthalmology, JJM Medical College, Davangere, Karnataka, India.
FAU - Kagathur, Shivanna
AU  - Kagathur S
AD  - Department of Ophthalmology, JJM Medical College, Davangere, Karnataka, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Myopia/diagnosis
MH  - Nerve Fibers
MH  - *Optic Disk
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
PMC - PMC8374803
OTO - NOTNLM
OT  - GCIPL
OT  - RNFL
OT  - myopia
OT  - optic disc area
COIS- None
EDAT- 2021/06/20 06:00
MHDA- 2021/07/01 06:00
PMCR- 2021/07/01
CRDT- 2021/06/19 12:05
PHST- 2021/06/19 12:05 [entrez]
PHST- 2021/06/20 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2021_69_7_1820_318591 [pii]
AID - IJO-69-1820 [pii]
AID - 10.4103/ijo.IJO_2818_20 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2021 Jul;69(7):1820-1824. doi: 10.4103/ijo.IJO_2818_20.