PMID- 34146699
OWN - NLM
STAT- MEDLINE
DCOM- 20211223
LR  - 20211223
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 248
DP  - 2021 Oct
TI  - Chitosan nanoparticles alleviated endocrine disruption, oxidative damage, and 
      genotoxicity of Bisphenol-A- intoxicated female African catfish.
PG  - 109104
LID - S1532-0456(21)00131-9 [pii]
LID - 10.1016/j.cbpc.2021.109104 [doi]
AB  - Bisphenol-A (BPA) is widely used in production of plastic products. It can reach 
      the ecosystems affecting aquatic organisms most likely fishes. The purpose of 
      this study was to study the toxic effects of BPA on the biochemical variables and 
      oxidative stress in female African catfish, Clarias gariepinus and to estimate 
      the protective role of chitosan nanoparticles (CSNPs) against BPA toxicity. Five 
      groups in triplicates of fish were divided as follows: group I was control, group 
      II was treated with CSNPs (0.66 ml/L), group III was exposed to BPA (1.43 mug/L), 
      group IV was treated with BPA (1.43 mug/L) plus CSNPs (0.33 ml/L), and group V was 
      treated with BPA (1.43 mug/L) plus CSNPs (0.66 ml/L) for 30 days. Blood and liver 
      tissue samples were collected at the end of experiment for the biochemical and 
      oxidative stress biomarkers analyses. Results exhibited that serum Follicle 
      Stimulating Hormone (FSH) and 17-beta Estradiol (E2) were significantly decreased in 
      female catfish. While, serum Testosterone (T.) and Luteinizing Hormone (LH) were 
      increased after exposure to BPA. Marked increment in superoxide dismutase (SOD) 
      and malondialdehyde (MDA) levels of hepatic tissue of catfish exposed to BPA. 
      Furthermore, significant reduction in hepatic catalase (CAT), glutathione 
      peroxidase (GSH-px), total antioxidant capacity (TAC), reduced glutathione (GSH), 
      and glutathione S-transferase (GST) levels were decreased significantly in 
      BPA-exposed catfish compared to the control group. However, administration of 
      female C. gariepinus with the low and high doses (0.33 ml/L and 0.66 ml/L) of 
      CNPs restored the biochemical parameters to be close to the normal values of the 
      control group and also, reduced oxidative stress induced by BPA toxicity. This 
      improvement was evident in fish administrated with the high CSNPs dose 
      (0.66 ml/L) compared to catfish exposed to BPA in group (III). Furthermore, the 
      percentage of hepatic DNA damage was detected in group III exposed to BPA alone. 
      However, it was declined after co- administration with both the low and high 
      doses of CSNPs. The study has revealed that treatment with CSNPs has antagonistic 
      functions against the toxicity of BPA in female African catfish.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Hamed, Heba S
AU  - Hamed HS
AD  - Department of Zoology, Faculty of women for Arts, Science & Education, Ain Shams 
      University, Cairo 11757, Egypt. Electronic address: hebasalah84@women.asu.edu.eg.
FAU - Ali, Rokaya M
AU  - Ali RM
AD  - Department of Zoology, Faculty of women for Arts, Science & Education, Ain Shams 
      University, Cairo 11757, Egypt.
FAU - Shaheen, Adel A
AU  - Shaheen AA
AD  - Department of Aquatic animals Diseases and Management, Faculty of Veterinary 
      Medicine, Banha University, Banha, Egypt.
FAU - Hussein, Naema M
AU  - Hussein NM
AD  - Department of Zoology, Faculty of women for Arts, Science & Education, Ain Shams 
      University, Cairo 11757, Egypt.
LA  - eng
PT  - Clinical Trial, Veterinary
PT  - Journal Article
DEP - 20210617
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Biomarkers)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9012-76-4 (Chitosan)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/chemistry/*toxicity
MH  - Biomarkers/metabolism
MH  - *Catfishes
MH  - Chemical and Drug Induced Liver Injury/prevention & control/veterinary
MH  - Chitosan/administration & dosage/*pharmacology
MH  - DNA Fragmentation/drug effects
MH  - Endocrine Disruptors/*toxicity
MH  - Estrogens, Non-Steroidal/toxicity
MH  - Female
MH  - Malondialdehyde/metabolism
MH  - Molecular Structure
MH  - Nanoparticles/administration & dosage/*chemistry
MH  - Oxidative Stress/drug effects
MH  - Phenols/chemistry/*toxicity
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Bisphenol-A
OT  - Chitosan nanoparticles
OT  - Clarias gariepinus
OT  - DNA damage
OT  - Oxidative stress
OT  - Reproductive hormones
EDAT- 2021/06/20 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/06/19 20:12
PHST- 2021/04/10 00:00 [received]
PHST- 2021/05/31 00:00 [revised]
PHST- 2021/06/06 00:00 [accepted]
PHST- 2021/06/20 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/06/19 20:12 [entrez]
AID - S1532-0456(21)00131-9 [pii]
AID - 10.1016/j.cbpc.2021.109104 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2021 Oct;248:109104. doi: 
      10.1016/j.cbpc.2021.109104. Epub 2021 Jun 17.