PMID- 34148148 OWN - NLM STAT- MEDLINE DCOM- 20210629 LR - 20220113 IS - 1862-3514 (Electronic) VI - 16 IP - 1 DP - 2021 Jun 19 TI - Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data. PG - 98 LID - 10.1007/s11657-021-00947-0 [doi] AB - We performed a nationwide, population-based cohort study to evaluate the risk of osteoporosis and osteoporotic fracture in patients with breast cancer using the data from Korean Genome and Epidemiology Study (KoGES) and concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, regardless of age. PURPOSE: This study aimed to evaluate the association between breast cancer and the occurrence of osteoporosis and osteoporotic fracture using data from the Korean Genome and Epidemiology Study (KoGES). METHODS: Using the national KoGES health examinee (HEXA) data consisting of data from urban resident participants >/= 40 years old, we extracted data for patients with breast cancer (n = 1080) and for control participants (n = 106,993); we then analyzed the occurrence of osteoporosis and osteoporotic fracture at baseline from 2004 to 2013 and during follow-up from 2012 to 2016. A logistic regression model was used to analyze the odds ratios (ORs) and the 95% confidence intervals (CIs). Subgroup analysis was performed based on age (younger group aged /= 52 years old). RESULTS: The ORs (95% CIs) for osteoporosis and osteoporotic fracture were 1.54 (95% CI = 1.28-1.84, P < 0.001) and 1.01 (95% CI = 0.82-1.23, P = 0.949), respectively, in the breast cancer group. In the subgroup analysis based on age, the ORs (95% CIs) for osteoporosis were 2.41 (95% CI = 1.70-3.43, P < 0.001) in the younger group and 1.33 (95% CI = 1.08-1.64, P = 0.007) in the older group of breast cancer patients. The ORs (95% CIs) for osteoporotic fracture were 1.15 (95% CI = 0.81-1.63, P = 0.441) in the younger group and 0.95 (95% CI = 0.74-1.21, P = 0.661) in the older group of breast cancer patients. CONCLUSION: We concluded that Korean women with breast cancer had a higher risk of osteoporosis than healthy women, but the same finding was not observed for osteoporotic fracture, regardless of age. FAU - Choi, Hyo Geun AU - Choi HG AD - Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea. AD - Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea. FAU - Suh, Yong Joon AU - Suh YJ AD - Department of Breast and Endocrine Surgery, Hallym University College of Medicine, Anyang, Republic of Korea. FAU - Lee, Jung Woo AU - Lee JW AD - Department of Orthopedic Surgery, Yonsei University Wonju College of Medicine, Wonju, South Korea. FAU - Min, Chan Yang AU - Min CY AD - Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea. FAU - Yoo, Dae Myoung AU - Yoo DM AD - Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea. FAU - Lee, Suk Woo AU - Lee SW AUID- ORCID: 0000-0001-9200-8728 AD - Department of Obstetrics and Gynecology, Hallym University College of Medicine, Anyang, Republic of Korea. ssugucap@naver.com. AD - Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, Republic of Korea. ssugucap@naver.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210619 PL - England TA - Arch Osteoporos JT - Archives of osteoporosis JID - 101318988 SB - IM MH - Adult MH - *Breast Neoplasms MH - Cohort Studies MH - Cross-Sectional Studies MH - Female MH - Humans MH - Middle Aged MH - *Osteoporosis MH - *Osteoporotic Fractures MH - Risk Factors OTO - NOTNLM OT - Breast cancer OT - Cohort study OT - Korea Genome and Epidemiology Study OT - Nested case-control study OT - Osteoporosis EDAT- 2021/06/21 06:00 MHDA- 2021/06/30 06:00 CRDT- 2021/06/20 21:01 PHST- 2020/10/21 00:00 [received] PHST- 2021/04/29 00:00 [accepted] PHST- 2021/06/20 21:01 [entrez] PHST- 2021/06/21 06:00 [pubmed] PHST- 2021/06/30 06:00 [medline] AID - 10.1007/s11657-021-00947-0 [pii] AID - 10.1007/s11657-021-00947-0 [doi] PST - epublish SO - Arch Osteoporos. 2021 Jun 19;16(1):98. doi: 10.1007/s11657-021-00947-0.