PMID- 34148891
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20240321
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 46
IP  - 5
DP  - 2021 May 28
TI  - RNA methylation and neurovascular unit remodeling.
PG  - 536-544
LID - 1672-7347(2021)05-0536-09 [pii]
LID - 10.11817/j.issn.1672-7347.2021.200246 [doi]
AB  - RNA methylation is of great significance in the regulation of gene expression, 
      among which the more important methylation modifiers are N6-methyladenosine (m6A) 
      and 5-methylcytosine (m5C). The methylation process is mainly regulated by 3 
      kinds of proteins: methyltransferase, demethylase, and reader. m6A, m5C, and 
      their related proteins have high abundance in the brain, and they have important 
      roles in the development of the nervous system and the repair and remodeling of 
      the vascular system. The neurovascular unit (NVU) is a unit of brain structure 
      and function composed of neurons, capillaries, astrocytes, supporting cells, and 
      extracellular matrix. The local microenvironment for NVU has an important role in 
      nerve cell function repair, and the remodeling of NVU is of great significance in 
      the prognosis of various neurological diseases.
FAU - Lu, Xinyi
AU  - Lu X
AD  - Department of Neurology, Xiangya Hospital, Central South University, Changsha 
      410008, China. lvxinyi1368@163.com.
FAU - Fan, Yishu
AU  - Fan Y
AD  - Department of Neurology, Xiangya Hospital, Central South University, Changsha 
      410008, China.
FAU - Kang, Shuntong
AU  - Kang S
AD  - Department of Neurology, Xiangya Hospital, Central South University, Changsha 
      410008, China.
FAU - Xiao, Bo
AU  - Xiao B
AD  - Department of Neurology, Xiangya Hospital, Central South University, Changsha 
      410008, China.
FAU - Zhang, Mengqi
AU  - Zhang M
AD  - Department of Neurology, Xiangya Hospital, Central South University, Changsha 
      410008, China. zhangmengqi8912@163.com.
LA  - eng
LA  - chi
GR  - 81501025/the National Natural Science Foundation/
GR  - 2020SK2063/the Key Research and Development Program of Hunan Province/
GR  - 2020JJ4134/the Natural Science Foundation of Hunan Province/
PT  - Journal Article
TT  - RNA甲基化与神经血管单元重塑.
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 63231-63-0 (RNA)
RN  - 6R795CQT4H (5-Methylcytosine)
RN  - EC 2.1.1.- (Methyltransferases)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - 5-Methylcytosine
MH  - *Adenosine/metabolism
MH  - Methylation
MH  - *Methyltransferases/metabolism
MH  - RNA
PMC - PMC10930208
OAB - RNA methylation is of great significance in the regulation of gene expression, 
      among which the more important methylation modifiers are N6-methyladenosine (m6A) 
      and 5-methylcytosine (m5C). The methylation process is mainly regulated by 3 
      kinds of proteins: methyltransferase, demethylase, and reader. m6A, m5C, and 
      their related proteins have high abundance in the brain, and they have important 
      roles in the development of the nervous system and the repair and remodeling of 
      the vascular system. The neurovascular unit (NVU) is a unit of brain structure 
      and function composed of neurons, capillaries, astrocytes, supporting cells, and 
      extracellular matrix. The local microenvironment for NVU has an important role in 
      nerve cell function repair, and the remodeling of NVU is of great significance in 
      the prognosis of various neurological diseases.
OABL- eng
OTO - NOTNLM
OT  - 5-methylcytosine
OT  - N6-methyladenosine
OT  - RNA methylation
OT  - blood vessel
OT  - neuron
OT  - neurovascular unit
COIS- 作者声称无任何利益冲突。
EDAT- 2021/06/22 06:00
MHDA- 2021/06/23 06:00
PMCR- 2021/05/28
CRDT- 2021/06/21 05:39
PHST- 2021/06/21 05:39 [entrez]
PHST- 2021/06/22 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/05/28 00:00 [pmc-release]
AID - 1672-7347(2021)05-0536-09 [pii]
AID - 10.11817/j.issn.1672-7347.2021.200246 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 May 28;46(5):536-544. doi: 
      10.11817/j.issn.1672-7347.2021.200246.