PMID- 34150102
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210622
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 5
DP  - 2021
TI  - Efficacy comparison of high-frequency oscillatory ventilation with continuous 
      nasal positive airway pressure in neonatal respiratory distress syndrome 
      treatment.
PG  - 5137-5146
AB  - OBJECTIVES: To compare the treatment efficacy of high-frequency oscillatory 
      ventilation (HFOV) with nasal continuous positive airway pressure (NCPAP) in the 
      treatment of neonatal respiratory distress syndrome (NRDS) and its effect on the 
      expression of high-mobility group protein B1 (HMGB1). METHODS: A total of 180 
      infants with NRDS admitted to our hospital were included and randomly assigned 
      into the HFOV group (receiving conventional therapy and HFOV), the NCPAP group 
      (receiving conventional therapy and NCPAP), and the conventional group (receiving 
      conventional therapy). Qi and blood indicators, heart rate, respiratory 
      frequency, PCO(2), and PaO(2) were observed and recorded before and after 
      treatment, together with complications after treatment. ELISA was performed for 
      HMGB1 Results: A distinctly lower partial pressure of carbon dioxide (PCO(2)) but 
      higher arterial partial pressure of oxygen (PaO(2)) was observed in the HFOV and 
      NCPAP groups than in the conventional group (P < 0.05), whereas infants in the 
      HFOV group exhibited slight differences in these two indicators from their 
      counterparts in the NCPAP group (P > 0.05). The serum HMGB1 levels in both groups 
      were significantly higher than those in the conventional group (P < 0.05). 
      DISCUSSION: Both HFOV and NCPAP are feasible in the treatment of NRDS and may 
      play a role in the inhibition of HMGB1.
CI  - AJTR Copyright (c) 2021.
FAU - Lin, Jincai
AU  - Lin J
AD  - Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian 
      Medical University Fuzhou 350001, Fujian, China.
FAU - Shen, Ying
AU  - Shen Y
AD  - Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian 
      Medical University Fuzhou 350001, Fujian, China.
FAU - Liu, Jiyuan
AU  - Liu J
AD  - Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian 
      Medical University Fuzhou 350001, Fujian, China.
FAU - Luo, Yinzhu
AU  - Luo Y
AD  - Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian 
      Medical University Fuzhou 350001, Fujian, China.
FAU - Ma, Xiaoying
AU  - Ma X
AD  - Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian 
      Medical University Fuzhou 350001, Fujian, China.
FAU - Zhang, Liyan
AU  - Zhang L
AD  - Department of Neonatology, The Affiliated Fuzhou Children Hospital of Fujian 
      Medical University Fuzhou 350001, Fujian, China.
LA  - eng
PT  - Journal Article
DEP - 20210515
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8205805
OTO - NOTNLM
OT  - HFOV
OT  - HMGB1
OT  - NCPAP
OT  - NRDS
OT  - conventional therapy
COIS- None.
EDAT- 2021/06/22 06:00
MHDA- 2021/06/22 06:01
PMCR- 2021/05/15
CRDT- 2021/06/21 05:55
PHST- 2021/01/03 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/06/21 05:55 [entrez]
PHST- 2021/06/22 06:00 [pubmed]
PHST- 2021/06/22 06:01 [medline]
PHST- 2021/05/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 May 15;13(5):5137-5146. eCollection 2021.