PMID- 34150144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 5
DP  - 2021
TI  - Application value of UPLC-MS/MS in detecting serum concentration of 
      anti-schizophrenic drugs in patients with mental illnes.
PG  - 5460-5467
AB  - OBJECTIVE: This study was designed to demonstrate the accuracy of ultra-high 
      performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in 
      detecting serum concentration of anti-schizophrenic drugs in patients with mental 
      illness. METHODS: The study participants were 186 schizophrenia patients treated 
      in our hospital. Serum concentrations of anti-schizophrenic drugs in Chinese 
      patients with mental illness were evaluated according to the reference intervals 
      of drug therapy recommended in the guidelines. RESULTS: Five drugs, namely 
      Aripiprazole (ARI), Amisulpride (AMI), Olanzapine (OLA), Paliperidone (PAL) and 
      Ziprasidone (ZIP) all showed good linearity within the linear range. The 
      within-day precision of the above five drugs was all between 1.3%-8.9% and the 
      inter-day precision was between 1.8%-7.6%, with within-day and inter-day relative 
      standard deviations (RSDs) less than 15.00% and accuracy ranging from 87.00% to 
      106.73%. However, AMI had a mean blood concentration of 436.31+/-241.05 ng/mL 
      (median concentration: 379.34 ng/mL), which was significantly higher than the 
      reference range (100-320 ng/mL) recommended in the guidelines. Good recovery 
      rates (86.21%-99.77%) were obtained after the samples were stored at room 
      temperature for 24 h, at 4 degrees C for 48h and at -20 degrees C for half a year. CONCLUSIONS: 
      Given that UPLC-MS/MS renders more accurate results in detecting the 
      concentration of psychotropic drugs, it can be applied clinically to detect the 
      concentration of therapeutic drugs in patients with mental illness.
CI  - AJTR Copyright (c) 2021.
FAU - Wu, Shaochang
AU  - Wu S
AD  - Department of Geriatrics, The Second People's Hospital of Lishui Lishui, Zhejiang 
      Province, China.
FAU - Zhu, Guidong
AU  - Zhu G
AD  - Department of Psychiatry, The Second People's Hospital of Lishui Lishui, Zhejiang 
      Province, China.
FAU - Zhou, Dajin
AU  - Zhou D
AD  - Clinical Laboratory, The Second People's Hospital of Lishui Lishui, Zhejiang 
      Province, China.
FAU - Xu, Hongtao
AU  - Xu H
AD  - Hangzhou Biozon Medical Co., Ltd. Hangzhou, Zhejiang Province, China.
FAU - Zhao, Longyou
AU  - Zhao L
AD  - Clinical Laboratory, The Second People's Hospital of Lishui Lishui, Zhejiang 
      Province, China.
LA  - eng
PT  - Journal Article
DEP - 20210515
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8205737
OTO - NOTNLM
OT  - Ultra-high performance liquid chromatography-tandem mass spectrometry
OT  - drug concentration
OT  - schizophrenia
COIS- None.
EDAT- 2021/06/22 06:00
MHDA- 2021/06/22 06:01
PMCR- 2021/05/15
CRDT- 2021/06/21 05:55
PHST- 2021/01/22 00:00 [received]
PHST- 2021/02/23 00:00 [accepted]
PHST- 2021/06/21 05:55 [entrez]
PHST- 2021/06/22 06:00 [pubmed]
PHST- 2021/06/22 06:01 [medline]
PHST- 2021/05/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 May 15;13(5):5460-5467. eCollection 2021.