PMID- 34151809
OWN - NLM
STAT- MEDLINE
DCOM- 20210915
LR  - 20210915
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 82
IP  - 3
DP  - 2021
TI  - Elevated Plasma Free Fatty Acid Susceptible to Early Cognitive Impairment in Type 
      2 Diabetes Mellitus.
PG  - 1345-1356
LID - 10.3233/JAD-210403 [doi]
AB  - BACKGROUND: Elevated free fatty acid (FFA) induces lipotoxicity, attributed to 
      diabetes and cognitive decline. Sterol regulatory element-binding protein-1c 
      (SREBP-1c) regulates lipid metabolism. OBJECTIVE: We investigated the roles of 
      FFA in mild cognitive impairment (MCI) of type 2 diabetes mellitus (T2DM) 
      patients and determine its association with rs11868035 polymorphism. METHODS: We 
      recruited 191 Chinese T2DM patients into two groups through Montreal Cognitive 
      Assessment. Demographic and clinical data were collected, multiple domain 
      cognitive functions were tested, plasma FFA levels were measured through ELISA, 
      and SREBP-1c rs11868035 genotype was detected using the Seqnome method. RESULTS: 
      In comparison with the healthy-cognition group (n = 128), the MCI group (n = 63) 
      displayed lower glucose control (p = 0.012) and higher plasma FFA level 
      (p = 0.021), which were independent risk factors of MCI in T2DM patients in 
      multivariate regression analysis (OR = 1.270, p = 0.003; OR = 1.005, p = 0.036). 
      Additionally, the plasma FFA levels of MCI patients were positively correlated 
      with Stroop color word test-C time scores (r = 0.303, p = 0.021) and negatively 
      related to apolipoprotein A1 levels (r = -0.311, p = 0.017), which are associated 
      positively with verbal fluency test scores (r = 0.281, p = 0.033). Both scores 
      reflected attention ability and executive function. Moreover, the G allele 
      carriers of rs11868035 showed higher digit span test scores than non-carriers in 
      T2DM patients (p = 0.019) but without correlation with plasma FFA levels. 
      CONCLUSION: In T2DM, elevated plasma level of FFA, when combined with lower 
      apolipoprotein A1 level portends abnormal cholesterol transport, were susceptible 
      to early cognitive impairment, especially for attention and execution deficits. 
      The G allele of SREBP-1c rs11868035 may be a protective factor for memory.
FAU - Zhu, Wenwen
AU  - Zhu W
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Xu, Lan
AU  - Xu L
AD  - The Affiliated Wuxi People's Hospital of Nanjing Medical University, Xuzhou, 
      China.
FAU - Zhang, Haoqiang
AU  - Zhang H
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Tian, Sai
AU  - Tian S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - An, Ke
AU  - An K
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Cao, Wuyou
AU  - Cao W
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Shi, Jijing
AU  - Shi J
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Tang, Wei
AU  - Tang W
AD  - Department of Endocrinology, Geriatric Hospital of Nanjing Medical University, 
      Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids, Nonesterified)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - Cognitive Dysfunction/*blood/*diagnosis/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis/epidemiology
MH  - Disease Susceptibility/*blood/diagnosis/epidemiology
MH  - Fatty Acids, Nonesterified/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
OTO - NOTNLM
OT  - Free fatty acid
OT  - lipid profile
OT  - mild cognitive impairment
OT  - sterol regulatory element-binding protein-1c
OT  - type 2 diabetes mellitus.
EDAT- 2021/06/22 06:00
MHDA- 2021/09/16 06:00
CRDT- 2021/06/21 08:50
PHST- 2021/06/22 06:00 [pubmed]
PHST- 2021/09/16 06:00 [medline]
PHST- 2021/06/21 08:50 [entrez]
AID - JAD210403 [pii]
AID - 10.3233/JAD-210403 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2021;82(3):1345-1356. doi: 10.3233/JAD-210403.