PMID- 3415279
OWN - NLM
STAT- MEDLINE
DCOM- 19880926
LR  - 20190717
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 124
IP  - 9
DP  - 1988 Sep
TI  - Association of herpes simplex virus-induced erythema multiforme with the human 
      leukocyte antigen DQw3.
PG  - 1372-5
AB  - We studied the genetic markers in human leukocyte antigen (HLA) region HLA-A, -B, 
      -C, -DR, -DQ, C2, Bf, C4A, and C4B of 31 patients with erythema multiforme (EM) 
      and their families. In contrast to the complement allotypes, which showed no 
      deviation from the distribution in the normal population, two HLA class II 
      antigens occurred in much higher frequency in patients with EM. The frequency of 
      HLA-DQw3 (77.4%) increased with high significance compared with normal Caucasian 
      control individuals (41.2%). An even stronger DQw3 association was found in the 
      patient group with postherpetic EM (88.8%; relative risk, 9.41). Interestingly, 
      all patients suffering from frequently recurrent EM were found to have the DQw3 
      allele (relative risk 44.2). The previously reported association to HLA-B15 was 
      also seen and may be due to a linkage disequilibrium with the HLA-DR4 allele 
      (66.6% in recurrent EM). Our data provide further evidence that classic recurrent 
      EM is related to herpes simplex virus infection and should be regarded as a 
      distinct entity within the enigmatic EM syndrome. DQw3 may serve as a helpful 
      marker for distinguishing this entity from other diseases with EM-like lesions.
FAU - Kampgen, E
AU  - Kampgen E
AD  - Institut fur Immunologie, Ludwig-Maximilians-Universitat, Munich, West Germany.
FAU - Burg, G
AU  - Burg G
FAU - Wank, R
AU  - Wank R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ3 antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Erythema Multiforme/*immunology
MH  - Female
MH  - HLA-D Antigens/*analysis
MH  - HLA-DQ Antigens/*analysis/genetics
MH  - HLA-DR Antigens/analysis
MH  - Herpes Simplex/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
AID - 10.1001/archderm.1988.01670090028005 [doi]
PST - ppublish
SO  - Arch Dermatol. 1988 Sep;124(9):1372-5. doi: 10.1001/archderm.1988.01670090028005.