PMID- 34154432
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210709
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 49
IP  - 6
DP  - 2021 Jun
TI  - Factors associated with microvascular occlusion in patients with ST elevation 
      myocardial infarction after primary percutaneous coronary intervention.
PG  - 3000605211024490
LID - 10.1177/03000605211024490 [doi]
LID - 03000605211024490
AB  - OBJECTIVE: This study aimed to determine predictors of microvascular occlusion 
      (MVO) in patients with ST elevation myocardial infarction (STEMI) after primary 
      percutaneous coronary intervention (pPCI). METHODS: This retrospective, 
      observational study consecutively included 113 patients with STEMI undergoing 
      pPCI. Cardiac magnetic resonance imaging was used to determine the presence of 
      MVO in these patients. Biomarkers in serum were routinely tested 1 day after 
      pPCI. Multivariable logistic regression analysis was used to evaluate significant 
      predictors of occurrence of MVO. RESULTS: There were 62 patients in the MVO group 
      and 51 patients in the non-MVO group. C-reactive protein (CRP), thrombomodulin, 
      lymphatic vessel endothelial hyaluronan receptor-1, syndecan-1, and troponin T 
      (TnT) levels after the procedure were significantly higher in the MVO group than 
      in the non-MVO group. CRP (hazard ratio [HR]=1.036), TnT (HR=1.316), and 
      syndecan-1 (HR=1.986) levels were independently associated with MVO in patients 
      with acute myocardial infarction after pPCI. CONCLUSIONS: Levels of CRP, TnT, and 
      syndecan-1 can be used as serum biomarkers for MVO in patients with STEMI 
      receiving pPCI.
FAU - Huang, Yinhao
AU  - Huang Y
AD  - Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of 
      Nanjing Medical University, Nanjing, China.
FAU - Lei, Dazhou
AU  - Lei D
AD  - Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of 
      Nanjing Medical University, Nanjing, China.
FAU - Chen, Ziwei
AU  - Chen Z
AUID- ORCID: 0000-0001-8211-6805
AD  - Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of 
      Nanjing Medical University, Nanjing, China.
FAU - Xu, Biao
AU  - Xu B
AD  - Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of 
      Nanjing Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Coronary Circulation
MH  - Humans
MH  - Microcirculation
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Retrospective Studies
MH  - *ST Elevation Myocardial Infarction/diagnostic imaging/surgery
PMC - PMC8236804
OTO - NOTNLM
OT  - C-reactive protein
OT  - Microvascular occlusion
OT  - ST elevation myocardial infarction
OT  - primary percutaneous coronary intervention
OT  - syndecan-1
OT  - troponin T
COIS- Declaration of conflicting interest: The authors declare that there is no 
      conflict of interest.
EDAT- 2021/06/23 06:00
MHDA- 2021/06/24 06:00
PMCR- 2021/06/22
CRDT- 2021/06/22 05:29
PHST- 2021/06/22 05:29 [entrez]
PHST- 2021/06/23 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2021/06/22 00:00 [pmc-release]
AID - 10.1177_03000605211024490 [pii]
AID - 10.1177/03000605211024490 [doi]
PST - ppublish
SO  - J Int Med Res. 2021 Jun;49(6):3000605211024490. doi: 10.1177/03000605211024490.