PMID- 34154600
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20220420
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 19
IP  - 1
DP  - 2021 Jun 21
TI  - Sexually transmitted infections and semen quality from subfertile men with and 
      without leukocytospermia.
PG  - 92
LID - 10.1186/s12958-021-00769-2 [doi]
LID - 92
AB  - BACKGROUND: The role of sexually transmitted infections (STIs) in semen 
      parameters and male infertility is still a controversial area. Previous studies 
      have found bacterial infection in a minority of infertile leukocytospermic males. 
      This study aims to investigate the prevalence of STIs in semen from subfertile 
      men with leukocytospermia (LCS) and without leukocytospermia (non-LCS) and their 
      associations with sperm quality. METHODS: Semen samples were collected from 195 
      men who asked for a fertility evaluation. Infection with the above 6 pathogens 
      was assessed in each sample. Sperm quality was compared in subfertile men with 
      and without LCS. RESULTS: The LCS group had significantly decreased semen volume, 
      sperm concentration, progressive motility, total motility and normal morphology. 
      The infection rates of Ureaplasma urealyticum (Uuu), Ureaplasma parvum (Uup), 
      Mycoplasma hominis (MH), Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), 
      herpes simplex virus-2 (HSV-2) and Neisseria gonorrhoeae (NG) were 8.7 %, 21.0 %, 
      8.2 %, 2.1 %, 3.6 %, 1.0 and 0 %, respectively. The STI detection rates of 
      patients with LCS were higher than those of the non-LCS group (52.3 % vs. 
      39.3 %), although there was no statistically significant difference between the 
      two groups (P = 0.07). All semen parameters were not significantly different 
      between LCS with STIs and without STIs, except the semen volume in the 
      MG-infected patients with LCS was significantly lower than that in the 
      noninfected group. CONCLUSIONS: LCS was associated with a reduction in semen 
      quality, but was not associated with STIs.
FAU - Bai, Shun
AU  - Bai S
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Li, Yuan
AU  - Li Y
AD  - Dermatology Department, The Fifth People's Hospital of Hainan Province, 570100, 
      Haikou, Hainan, P.R. China.
FAU - Wan, Yangyang
AU  - Wan Y
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Guo, Tonghang
AU  - Guo T
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Jin, Qi
AU  - Jin Q
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Liu, Ran
AU  - Liu R
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Tang, Wenjuan
AU  - Tang W
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Sang, Meiying
AU  - Sang M
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Tao, Yuanyuan
AU  - Tao Y
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Xie, Baoguo
AU  - Xie B
AD  - Reproductive Medicine Center, the First Affiliated Hospital of Hainan Medical 
      University, 570102, Haikou, Hainan, P.R. China.
FAU - Zhao, Yun
AU  - Zhao Y
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Li, Wei
AU  - Li W
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Xu, Xiangdong
AU  - Xu X
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China.
FAU - Yue, Qiuling
AU  - Yue Q
AD  - Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, 210008, Nanjing, Jiangsu, P.R. China. 
      yulychina@163.com.
FAU - Hu, Xuechun
AU  - Hu X
AD  - Department of Urology, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, 230001, P.R. China. b091230028@163.com.
FAU - Xu, Bo
AU  - Xu B
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, Anhui, 230001, P.R. China. bio_xubo@163.com.
LA  - eng
GR  - 81901543/National Natural Science Foundation of China/
GR  - 81901545/National Natural Science Foundation of China/
GR  - 81971333/National Natural Science Foundation of China/
GR  - 82001495/National Natural Science Foundation of China/
GR  - WK9110000063/the Fundamental Research Funds for the Central Universities/
GR  - SKLRM-K201904/State Key Laboratory of Reproductive Medicine/
GR  - 1908085QH315/Natural Science Foundation of Anhui Provincial of China/
GR  - 2019YFA0802600/the National Key Research and Development Project/
PT  - Comparative Study
PT  - Journal Article
DEP - 20210621
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
SB  - IM
EIN - Reprod Biol Endocrinol. 2022 Apr 19;20(1):69. PMID: 35440000
MH  - Adult
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Infertility, Male/diagnosis/epidemiology/*microbiology
MH  - Leukocytes/*microbiology/physiology
MH  - Male
MH  - Semen/*microbiology/physiology
MH  - Semen Analysis/*methods
MH  - Sexually Transmitted Diseases/diagnosis/epidemiology/*microbiology
PMC - PMC8218447
OTO - NOTNLM
OT  - Leukocytospermia
OT  - Semen parameters
OT  - Sexually transmitted infections
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/23 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/06/21
CRDT- 2021/06/22 05:37
PHST- 2021/02/07 00:00 [received]
PHST- 2021/05/25 00:00 [accepted]
PHST- 2021/06/22 05:37 [entrez]
PHST- 2021/06/23 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/06/21 00:00 [pmc-release]
AID - 10.1186/s12958-021-00769-2 [pii]
AID - 769 [pii]
AID - 10.1186/s12958-021-00769-2 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2021 Jun 21;19(1):92. doi: 10.1186/s12958-021-00769-2.