PMID- 34157349 OWN - NLM STAT- MEDLINE DCOM- 20211129 LR - 20221003 IS - 1097-6833 (Electronic) IS - 0022-3476 (Print) IS - 0022-3476 (Linking) VI - 237 DP - 2021 Oct TI - Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth. PG - 148-153.e3 LID - S0022-3476(21)00556-4 [pii] LID - 10.1016/j.jpeds.2021.06.026 [doi] AB - OBJECTIVE: To evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants. STUDY DESIGN: EPT infants (24(0/7)-27(6/7) weeks of gestation) enrolled in the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) were included. EPT infants who died before 36 weeks of postmenstrual age (PMA) were excluded. The growth rates from birth to 36 weeks of PMA and follow-up outcomes at 18-22 months corrected age of EPT infants randomized at birth to either early CPAP (intervention group) or early intubation for surfactant administration (control group) were analyzed. RESULTS: Growth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well as growth rates during multiple intervals from birth to day 7, days 7-14, days 14-21, days 21-28, day 28 to 32 weeks PMA, and 32-36 weeks PMA did not differ between treatment groups. Independent of treatment group, higher growth rates from day 21 to day 28 were associated with a lower risk of having a Bayley-III cognitive score <85 at 18-22 months corrected age (P = .002). CONCLUSIONS: EPT infants randomized to early CPAP did not have higher in-hospital growth rates than infants randomized to early intubation. CI - Copyright (c) 2021 Elsevier Inc. All rights reserved. FAU - Salas, Ariel A AU - Salas AA AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: asalas@peds.uab.edu. FAU - Carlo, Waldemar A AU - Carlo WA AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. FAU - Do, Barbara T AU - Do BT AD - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC. FAU - Bell, Edward F AU - Bell EF AD - Department of Pediatrics, University of Iowa, Iowa City, IA. FAU - Das, Abhik AU - Das A AD - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC. FAU - Van Meurs, Krisa P AU - Van Meurs KP AD - Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA. FAU - Poindexter, Brenda B AU - Poindexter BB AD - Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA. FAU - Shankaran, Seetha AU - Shankaran S AD - Department of Pediatrics, Wayne State University, Detroit, MI. FAU - Younge, Noelle AU - Younge N AD - Department of Pediatrics, Duke University, Durham, NC. FAU - Watterberg, Kristi L AU - Watterberg KL AD - University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Higgins, Rosemary D AU - Higgins RD AD - National Institute of Child Health and Human Development, Bethesda, MD; Department of Global and Community Health, George Mason University, Fairfax, VA. CN - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network LA - eng GR - UG1 HD068263/HD/NICHD NIH HHS/United States GR - U10 HD021373/HD/NICHD NIH HHS/United States GR - K23 HD102554/HD/NICHD NIH HHS/United States GR - UG1 HD087226/HD/NICHD NIH HHS/United States GR - U01 HD036790/HD/NICHD NIH HHS/United States GR - K23 DK120960/DK/NIDDK NIH HHS/United States GR - UG1 HD068270/HD/NICHD NIH HHS/United States GR - UG1 HD053089/HD/NICHD NIH HHS/United States GR - UG1 HD027856/HD/NICHD NIH HHS/United States GR - UG1 HD034216/HD/NICHD NIH HHS/United States GR - UG1 HD027904/HD/NICHD NIH HHS/United States GR - UG1 HD027880/HD/NICHD NIH HHS/United States GR - U10 HD068284/HD/NICHD NIH HHS/United States GR - UG1 HD053109/HD/NICHD NIH HHS/United States GR - UG1 HD027851/HD/NICHD NIH HHS/United States GR - U10 HD036790/HD/NICHD NIH HHS/United States GR - UG1 HD068244/HD/NICHD NIH HHS/United States GR - UG1 HD027853/HD/NICHD NIH HHS/United States GR - UG1 HD087229/HD/NICHD NIH HHS/United States GR - UL1 TR003167/TR/NCATS NIH HHS/United States GR - UG1 HD040689/HD/NICHD NIH HHS/United States GR - UG1 HD068284/HD/NICHD NIH HHS/United States GR - UG1 HD021385/HD/NICHD NIH HHS/United States GR - UG1 HD040492/HD/NICHD NIH HHS/United States GR - UG1 HD021364/HD/NICHD NIH HHS/United States GR - UG1 HD068278/HD/NICHD NIH HHS/United States GR - U24 HD095254/HD/NICHD NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20210619 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 RN - 0 (Pulmonary Surfactants) SB - IM MH - Child Development/*physiology MH - *Continuous Positive Airway Pressure MH - Energy Intake MH - Female MH - Gestational Age MH - Humans MH - Infant, Extremely Premature MH - Infant, Newborn MH - *Intubation, Intratracheal MH - Male MH - Neurodevelopmental Disorders/*epidemiology MH - Oximetry MH - Pulmonary Surfactants/therapeutic use MH - Respiratory Distress Syndrome, Newborn/mortality/physiopathology/*therapy PMC - PMC8478787 MID - NIHMS1716902 COIS- The other authors declare no conflicts of interest. 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Cole L FIR - Osborne, Karen A IR - Osborne KA FIR - Spencer, Cynthia IR - Spencer C FIR - Steffens, Mike IR - Steffens M FIR - Weaver-Lewis, Kimberlee IR - Weaver-Lewis K FIR - Zanetti, Karen IR - Zanetti K FIR - O'Shea, T Michael IR - O'Shea TM FIR - Dillard, Robert G IR - Dillard RG FIR - Washburn, Lisa K IR - Washburn LK FIR - Peters, Nancy J IR - Peters NJ FIR - Jackson, Barbara G IR - Jackson BG FIR - Chiu, Korinne IR - Chiu K FIR - Allred, Deborah Evans IR - Allred DE FIR - Goldstein, Donald J IR - Goldstein DJ FIR - Halfond, Raquel IR - Halfond R FIR - Peterson, Carroll IR - Peterson C FIR - Waldrep, Ellen L IR - Waldrep EL FIR - Welch, Cherrie D IR - Welch CD FIR - Morris, Melissa Whalen IR - Morris MW FIR - Hounshell, Gail Wiley IR - Hounshell GW FIR - Pappas, Athina IR - Pappas A FIR - Sood, Beena G IR - Sood BG FIR - Bara, Rebecca IR - Bara R FIR - Billian, Elizabeth IR - Billian E FIR - Goldston, Laura A IR - Goldston LA FIR - Johnson, Mary IR - Johnson M FIR - Ehrenkranz, Richard A IR - Ehrenkranz RA FIR - Bhandari, Vineet IR - Bhandari V FIR - Jacobs, Harris C IR - Jacobs HC FIR - Cervone, Pat IR - Cervone P FIR - Gettner, Patricia IR - Gettner P FIR - Konstantino, Monica IR - Konstantino M FIR - Poulsen, JoAnn IR - Poulsen J FIR - Taft, Janet IR - Taft J FIR - Butler, Christine G IR - Butler CG FIR - Close, Nancy IR - Close N FIR - Gilliam, Walter IR - Gilliam W FIR - Greisman, Sheila IR - Greisman S FIR - Romano, Elaine IR - Romano E FIR - Williams, Joanne IR - Williams J EDAT- 2021/06/23 06:00 MHDA- 2021/11/30 06:00 PMCR- 2022/10/01 CRDT- 2021/06/22 20:10 PHST- 2021/02/12 00:00 [received] PHST- 2021/05/03 00:00 [revised] PHST- 2021/06/15 00:00 [accepted] PHST- 2021/06/23 06:00 [pubmed] PHST- 2021/11/30 06:00 [medline] PHST- 2021/06/22 20:10 [entrez] PHST- 2022/10/01 00:00 [pmc-release] AID - S0022-3476(21)00556-4 [pii] AID - 10.1016/j.jpeds.2021.06.026 [doi] PST - ppublish SO - J Pediatr. 2021 Oct;237:148-153.e3. doi: 10.1016/j.jpeds.2021.06.026. Epub 2021 Jun 19.