PMID- 34158811
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20220118
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2021
DP  - 2021
TI  - Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with 
      Obsessive-Compulsive Disorder.
PG  - 9966378
LID - 10.1155/2021/9966378 [doi]
LID - 9966378
AB  - BACKGROUND: Patients with obsessive-compulsive disorder (OCD) experience 
      deficiencies in reward processing. The investigation of the reward circuit and 
      its essential connectivity may further clarify the pathogenesis of OCD. METHODS: 
      The current research was designed to analyze the nucleus accumbens (NAc) 
      functional connectivity at rest in medicine-free patients with OCD. Forty 
      medication-free patients and 38 gender-, education-, and age-matched healthy 
      controls (HCs) were recruited for resting-state functional magnetic resonance 
      imaging. Seed-based functional connectivity (FC) was used to analyze the data. 
      LIBSVM (library for support vector machines) was designed to identify whether 
      altered FC could be applied to differentiate OCD. RESULTS: Patients with OCD 
      showed remarkably decreased FC values between the left NAc and the bilateral 
      orbitofrontal cortex (OFC) and bilateral medial prefrontal cortex (MPFC) and 
      between the right NAc and the left OFC at rest in the reward circuit. Moreover, 
      decreased left NAc-bilateral MPFC connectivity can be deemed as a potential 
      biomarker to differentiate OCD from HCs with a sensitivity of 80.00% and a 
      specificity of 76.32%. CONCLUSION: The current results emphasize the importance 
      of the reward circuit in the pathogenesis of OCD.
CI  - Copyright (c) 2021 Yunhui Chen et al.
FAU - Chen, Yunhui
AU  - Chen Y
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Ou, Yangpan
AU  - Ou Y
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, 
      China.
FAU - Lv, Dan
AU  - Lv D
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Ma, Jidong
AU  - Ma J
AD  - Department of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, 
      Heilongjiang 150050, China.
FAU - Zhan, Chuang
AU  - Zhan C
AD  - Department of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, 
      Heilongjiang 150050, China.
FAU - Yang, Ru
AU  - Yang R
AD  - Department of Radiology, The Second Xiangya Hospital of Central South University, 
      Changsha, Hunan 410011, China.
FAU - Jia, Cuicui
AU  - Jia C
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Shang, Tinghuizi
AU  - Shang T
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Sun, Lei
AU  - Sun L
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Wang, Yuhua
AU  - Wang Y
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Sun, Zhenghai
AU  - Sun Z
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
FAU - Zhang, Guangfeng
AU  - Zhang G
AD  - Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical 
      University, Qiqihar, Heilongjiang 161000, China.
FAU - Wang, Xiaoping
AU  - Wang X
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, 
      China.
FAU - Guo, Wenbin
AU  - Guo W
AUID- ORCID: 0000-0002-1626-2465
AD  - National Clinical Research Center for Mental Disorders, Department of Psychiatry, 
      The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, 
      China.
FAU - Li, Ping
AU  - Li P
AUID- ORCID: 0000-0002-3241-3091
AD  - Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 
      161006, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210601
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Connectome
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Male
MH  - Nerve Net/physiopathology
MH  - Neuroimaging
MH  - Nucleus Accumbens/*physiopathology
MH  - Obsessive-Compulsive Disorder/*physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Psychological Tests
MH  - Rest
MH  - *Reward
MH  - Young Adult
PMC - PMC8187042
COIS- All authors declare no conflict of interest.
EDAT- 2021/06/24 06:00
MHDA- 2022/01/19 06:00
PMCR- 2021/06/01
CRDT- 2021/06/23 07:18
PHST- 2021/03/30 00:00 [received]
PHST- 2021/05/08 00:00 [revised]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/06/23 07:18 [entrez]
PHST- 2021/06/24 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 10.1155/2021/9966378 [doi]
PST - epublish
SO  - Neural Plast. 2021 Jun 1;2021:9966378. doi: 10.1155/2021/9966378. eCollection 
      2021.