PMID- 34160246 OWN - NLM STAT- MEDLINE DCOM- 20211126 LR - 20230224 IS - 1552-9924 (Electronic) IS - 0091-6765 (Print) IS - 0091-6765 (Linking) VI - 129 IP - 6 DP - 2021 Jun TI - In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort. PG - 67005 LID - 10.1289/EHP8325 [doi] LID - 067005 AB - BACKGROUND: In utero exposure to heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) may be associated with higher childhood blood pressure (BP), whereas trace elements selenium (Se) and manganese (Mn) may have protective antioxidant effects that modify metal-BP associations. OBJECTIVES: We examined the individual and joint effects of in utero exposure to Pb, Hg, Cd, Se, and Mn on childhood BP. METHODS: We used data from the Boston Birth Cohort (enrolled 2002-2013). We measured heavy metals and trace elements in maternal red blood cells collected 24-72 h after delivery. We calculated child BP percentile per the 2017 American Academy of Pediatrics Clinical Practice Guideline. We used linear regression models to estimate the association of each metal, and Bayesian kernel machine regression (BKMR) to examine metal coexposures, with child BP between 3 to 15 years of age. RESULTS: Our analytic sample comprised 1,194 mother-infant pairs (61% non-Hispanic Black, 20% Hispanic). Hg and Pb were not associated with child systolic BP (SBP). Se and Mn were inversely associated with child SBP percentiles, which, on average, were 6.23 points lower with a doubling of Se (95% CI: - 11.51, - 0.96) and 2.62 points lower with a doubling of Mn (95% CI: - 5.20, - 0.04). BKMR models showed similar results. Although Cd was not associated with child SBP overall, the inverse association between Mn and child SBP was stronger at higher levels of Cd (p-interaction = 0.04). Consistent with this finding, in utero exposure to cigarette smoke modified the Mn-child SBP association. Among children whose mothers smoked during pregnancy, a doubling of Mn was associated with a 10.09-point reduction in SBP percentile (95% CI: - 18.03, - 2.15), compared with a 1.49-point reduction (95% CI: - 4.21, 1.24) in children whose mothers did not smoke during pregnancy (p-interaction = 0.08). CONCLUSION: Se and Mn concentrations in maternal red blood cells collected 24-72 h after delivery were associated with lower child SBP at 3 to 15 years of age. There was an interaction between Mn and Cd on child SBP, whereby the protective association of Mn on child SBP was stronger among mothers who had higher Cd. The association of Mn and child SBP was also modified by maternal cigarette smoking-a source of Cd-during pregnancy. Optimizing in utero Se levels, as well as Mn levels in women who had high Cd or smoked during pregnancy, may protect offspring from developing high BP during childhood. https://doi.org/10.1289/EHP8325. FAU - Zhang, Mingyu AU - Zhang M AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA. FAU - Liu, Tiange AU - Liu T AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Wang, Guoying AU - Wang G AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Buckley, Jessie P AU - Buckley JP AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Guallar, Eliseo AU - Guallar E AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA. FAU - Hong, Xiumei AU - Hong X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Wang, Mei-Cheng AU - Wang MC AD - Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Wills-Karp, Marsha AU - Wills-Karp M AD - Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Wang, Xiaobin AU - Wang X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. FAU - Mueller, Noel T AU - Mueller NT AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. AD - Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA. LA - eng GR - 827990/AHA_/American Heart Association-American Stroke Association/United States GR - R01 ES031521/ES/NIEHS NIH HHS/United States GR - R01 HD098232/HD/NICHD NIH HHS/United States GR - K01 HL141589/HL/NHLBI NIH HHS/United States GR - R01 ES031272/ES/NIEHS NIH HHS/United States GR - R01 HD041702/HD/NICHD NIH HHS/United States GR - R01 HD086013/HD/NICHD NIH HHS/United States GR - R01 ES029531/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20210623 PL - United States TA - Environ Health Perspect JT - Environmental health perspectives JID - 0330411 RN - 0 (Metals, Heavy) RN - 0 (Trace Elements) RN - H6241UJ22B (Selenium) SB - IM CIN - Environ Health Perspect. 2021 Jun;129(6):61301. PMID: 34160248 MH - Bayes Theorem MH - Blood Pressure MH - Child MH - Female MH - Humans MH - *Metals, Heavy/toxicity MH - Pregnancy MH - *Selenium MH - *Trace Elements PMC - PMC8221032 EDAT- 2021/06/24 06:00 MHDA- 2021/11/27 06:00 PMCR- 2021/06/23 CRDT- 2021/06/23 12:15 PHST- 2021/06/23 12:15 [entrez] PHST- 2021/06/24 06:00 [pubmed] PHST- 2021/11/27 06:00 [medline] PHST- 2021/06/23 00:00 [pmc-release] AID - EHP8325 [pii] AID - 10.1289/EHP8325 [doi] PST - ppublish SO - Environ Health Perspect. 2021 Jun;129(6):67005. doi: 10.1289/EHP8325. Epub 2021 Jun 23.