PMID- 34160330
OWN - NLM
STAT- MEDLINE
DCOM- 20220801
LR  - 20220802
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Linking)
VI  - 28
IP  - 4
DP  - 2022 Aug
TI  - T Cells: A Growing Universe of Roles in Neurodegenerative Diseases.
PG  - 335-348
LID - 10.1177/10738584211024907 [doi]
AB  - T cells play a central role in homeostasis and host defense against infectious 
      diseases. T cell dysregulation can lead to recognizing self-antigens as foreign 
      antigens, causing a detrimental autoimmune response. T cell involvement in 
      multiple sclerosis (MS), long understood to be an autoimmune-mediated 
      neurodegenerative disease, is well characterized. More recently, a role for T 
      cells has also been identified for the neurodegenerative diseases Alzheimer's 
      disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 
      Interestingly, several alleles and variants of human leukocyte antigen (HLA) 
      genes have been classified as AD and PD risk genes. HLA codes for components of 
      major histocompatibility complex (MHC) class I or class II, both of which are 
      expressed by microglia, the innate immune cells of the central nervous system 
      (CNS). Thus, both microglia and T cells may potentially interact in an 
      antigen-dependent or independent fashion to shape the inflammatory cascade 
      occurring in neurodegenerative diseases. Dissecting the antigen specificity of T 
      cells may lead to new options for disease-modifying treatments in 
      neurodegenerative diseases. Here, we review the current understanding of T cells 
      in neurodegenerative diseases. We summarize the subsets of T cells, their 
      phenotype and potential functions in animal models and in human studies of 
      neurodegenerative diseases.
FAU - Dressman, Dallin
AU  - Dressman D
AUID- ORCID: 0000-0002-0792-1940
AD  - Department of Pharmacology, Columbia University, New York, NY, USA.
AD  - Department of Neurology, Columbia University, New York, NY, USA.
AD  - Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia 
      University, New York, NY, USA.
FAU - Elyaman, Wassim
AU  - Elyaman W
AD  - Department of Neurology, Columbia University, New York, NY, USA.
AD  - Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia 
      University, New York, NY, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210623
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
SB  - IM
MH  - *Alzheimer Disease
MH  - *Amyotrophic Lateral Sclerosis
MH  - Animals
MH  - Central Nervous System
MH  - Humans
MH  - *Neurodegenerative Diseases
MH  - *Parkinson Disease
MH  - T-Lymphocytes
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Parkinson's disease
OT  - T-cell lymphocytes
OT  - amyotrophic lateral sclerosis
OT  - cytotoxic T cells
OT  - helper T cells
OT  - microglia
OT  - multiple sclerosis
OT  - neurodegenerative disease
OT  - neuroinflammation
EDAT- 2021/06/24 06:00
MHDA- 2022/08/02 06:00
CRDT- 2021/06/23 12:18
PHST- 2021/06/24 06:00 [pubmed]
PHST- 2022/08/02 06:00 [medline]
PHST- 2021/06/23 12:18 [entrez]
AID - 10.1177/10738584211024907 [doi]
PST - ppublish
SO  - Neuroscientist. 2022 Aug;28(4):335-348. doi: 10.1177/10738584211024907. Epub 2021 
      Jun 23.