PMID- 34160424
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 25
DP  - 2021 Jun 25
TI  - Clinical acupuncture therapy for femur head necrosis: A protocol for systematic 
      review and meta analysis.
PG  - e26400
LID - 10.1097/MD.0000000000026400 [doi]
LID - e26400
AB  - BACKGROUND: Femur Head Necrosis (FHN) is a common clinical joint 
      orthopedic-related disease, and its incidence is increasing year by year. 
      Symptoms include dull pain and dull pain in the affected hip joint or its 
      surrounding joints. More severely, it can lead to limited joint movement and 
      inability to walk autonomously. Surgical treatment has many sequelae. The high 
      cost makes it unaffordable for patients, and the side effects of drug treatment 
      are unknown. A large number of clinical studies have shown that acupuncture is 
      effective in treating femoral head necrosis. Therefore, this systematic review 
      aims to explore the safety and effectiveness of acupuncture in the treatment of 
      femoral head necrosis. METHODS: We will conduct a comprehensive literature search 
      in Medline, PubMed, Cochrane Database of Systematic Reviews, Embase, Chinese 
      Biomedical Literatures Database (CBM), China National Knowledge Infrastructure 
      (CNKI), Wang FangDatabase (WF), Chinese Scientific Journal Database (VIP) from 
      inception to May 2021 without any language restriction. In addition, we will 
      retrieve the unpublished studies and the references of initially included 
      literature manually. The two reviewers will identify studies, extract data, and 
      assess the quality independently. The outcomes of interest include: total 
      effective rate; the total nasal symptom score; Hip function (Hip Harris joint 
      score, WOMAC hip score, hip joint Lequesne index score, Merle D 'Aubigne and hip 
      joint Postel score); Adverse events. Randomized clinical trials will be 
      collected, methodological quality will be evaluated using the Cochrane 
      risk-of-bias assessment tool, and the level of evidence will be rated using the 
      Grading of Recommendations, Assessment, Development and Evaluation approach. 
      Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity 
      test will be conducted between the studies, P < .1 and I2 > 50% are the 
      thresholds for the tests. We will utilize the fixed effects model or the random 
      effects model according to the size of heterogeneity. RESULTS: The meta-analysis 
      program will systematically evaluate the efficacy and safety of acupuncture in 
      the treatment of FHN patients. CONCLUSION: This study will investigate whether 
      acupuncture can be used as one of the non-surgical and non-pharmacological 
      therapies for the prevention or treatment of FHN. TRIAL REGISTRATION NUMBER: 
      INPLASY202150035.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Wang, Hongyu
AU  - Wang H
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Yang, Fengyun
AU  - Yang F
AD  - The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 
      Nanchang, China.
FAU - Cao, Zhiwen
AU  - Cao Z
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Luo, Yunfeng
AU  - Luo Y
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Liu, Jiangyuan
AU  - Liu J
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Yang, Zhijun
AU  - Yang Z
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Xia, Hanting
AU  - Xia H
AD  - The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 
      Nanchang, China.
FAU - Li, Fuwei
AU  - Li F
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Mao, Zhaochong
AU  - Mao Z
AD  - Jiangxi University of Traditional Chinese Medicine.
FAU - Yang, Wenlong
AU  - Yang W
AD  - The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 
      Nanchang, China.
LA  - eng
GR  - 2020ZGJ01/Jiangxi Provincial Administration of Traditional Chinese Medicine/
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Acupuncture Therapy/*adverse effects
MH  - Feasibility Studies
MH  - Femur Head Necrosis/complications/diagnosis/*therapy
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Musculoskeletal Pain/diagnosis/etiology/*therapy
MH  - Pain Management/adverse effects/*methods
MH  - Pain Measurement/statistics & numerical data
MH  - Randomized Controlled Trials as Topic
MH  - Severity of Illness Index
MH  - Systematic Reviews as Topic
MH  - Treatment Outcome
PMC - PMC8238343
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/06/24 06:00
MHDA- 2021/07/02 06:00
PMCR- 2021/06/25
CRDT- 2021/06/23 12:20
PHST- 2021/05/30 00:00 [received]
PHST- 2021/06/03 00:00 [accepted]
PHST- 2021/06/23 12:20 [entrez]
PHST- 2021/06/24 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2021/06/25 00:00 [pmc-release]
AID - 00005792-202106250-00047 [pii]
AID - MD-D-21-03932 [pii]
AID - 10.1097/MD.0000000000026400 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Jun 25;100(25):e26400. doi: 
      10.1097/MD.0000000000026400.