PMID- 34161163
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20220531
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 24
IP  - 6
DP  - 2021 Jun
TI  - Fermented Red Ginseng Alleviates Ovalbumin-Induced Inflammation in Mice by 
      Suppressing Interleukin-4 and Immunoglobulin E Expression.
PG  - 569-576
LID - 10.1089/jmf.2020.4854 [doi]
AB  - Ginseng (the root of Panax ginseng Meyer) has been reported to have many biologic 
      therapeutic effects, including anti-inflammatory properties, and ginsenosides are 
      considered as one of the factors responsible for these therapeutic effects. To 
      improve their therapeutic action, probiotic bacteria are used to ferment and 
      chemically transform ginsenosides in red ginseng (RG). In this study, we aimed to 
      investigate the beneficial effects of RG fermented by probiotic bacteria (FRG) 
      against ovalbumin (OVA)-induced allergic rhinitis in a mouse model. We induced 
      the mouse model via OVA inhalation; experimental results revealed increased 
      immunoglobulin E (IgE) and interleukin (IL)-4 levels, leading to Th2-type 
      cytokine response. The mice with induced allergy were then orally administered RG 
      and FRG over 2 weeks, as a result of which, IL-4 and IgE levels in 
      bronchoalveolar lavage fluid, nasal fluid, and serum were found to be ameliorated 
      more effectively by FRG than by RG, suggesting that FRG has better immune 
      regulatory effects than RG. FRG also downregulated immune cell levels, such as 
      those of eosinophils and basophils, and significantly decreased the thickness of 
      OVA-induced respiratory epithelium compared to RG. Collectively, the results 
      showed that FRG treatment alleviates inflammation, thereby extending a protective 
      effect to mice with OVA-induced inflammatory allergic rhinitis.
FAU - Bae, Chu Hyun
AU  - Bae CH
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Kim, Jisoo
AU  - Kim J
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Nam, Woo
AU  - Nam W
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Kim, Hyeonji
AU  - Kim H
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Kim, Jooyun
AU  - Kim J
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Nam, Bora
AU  - Nam B
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Park, Soodong
AU  - Park S
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Lee, Junglyoul
AU  - Lee J
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
FAU - Sim, Jaehun
AU  - Sim J
AD  - R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Cytokines)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Cytokines/genetics
MH  - Disease Models, Animal
MH  - *Fermented Foods
MH  - *Immunoglobulin E
MH  - Inflammation
MH  - *Interleukin-4/genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - Panax
MH  - *Rhinitis, Allergic/drug therapy
OTO - NOTNLM
OT  - OVA
OT  - allergic rhinitis
OT  - fermented red ginseng
OT  - probiotics
EDAT- 2021/06/24 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/06/23 17:14
PHST- 2021/06/23 17:14 [entrez]
PHST- 2021/06/24 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
AID - 10.1089/jmf.2020.4854 [doi]
PST - ppublish
SO  - J Med Food. 2021 Jun;24(6):569-576. doi: 10.1089/jmf.2020.4854.