PMID- 34161165
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 24
IP  - 6
DP  - 2021 Jun
TI  - Improvement of Fatigue Symptoms and Endurance Capacity by the Combined 
      Administration of Cervus elaphus L., Angelica gigas Nakai, and Astragalus 
      membranaceus Bunge.
PG  - 577-585
LID - 10.1089/jmf.2020.4743 [doi]
AB  - Fatigue is a common phenomenon usually observed in healthy, as well as in 
      nonhealthy, individuals that affects their performance and quality of life. 
      Efficient supplementation to relieve fatigue is of significant importance. This 
      study was designed to investigate the efficacy of three prescreened natural 
      resources (Cervus elaphus L. [CEL], Angelica gigas Nakai [AGN], and Astragalus 
      membranaceus Bunge [AMB]) against fatigue symptoms induced by heavy exercise. 
      Effects on muscle fatigue and endurance capacity during exercise were 
      investigated in C2C12 myoblasts and exercised mice. A combination of CEL, AGN, 
      and AMB (CEL:AGN:AMB, 1:2:1) treatment in myoblasts reduced intracellular 
      reactive oxygen species levels induced by hydrogen peroxide by  approximately 20 times 
      (P < .001). The optimal mixture extract combination was determined as 
      CEL:AGN:AMB, 1:2:1 (CAA), which was recombined by applying the extraction yield 
      of individual substance for in vivo study. Compared to the exercise control (EC) 
      group, the serum lactate dehydrogenase level decreased by  approximately 40% due to CAA 
      administration. The proliferator-activated receptor gamma coactivator 1-alpha 
      protein expression increased significantly (P < .05) after CAA administration 
      compared to that observed in the normal control group. In parallel, CAA treatment 
      significantly (P < .05) enhanced the maximum running time compared to the EC 
      group. Overall, combinatorial administration exhibited greater efficacy compared 
      to each individual treatment, indicating that CAA could be used as an efficient 
      ergogenic and antifatigue supplement.
FAU - Huang, Wen Yan
AU  - Huang WY
AD  - Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Youk, Jin Soo
AU  - Youk JS
AD  - Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Han, Bok Kyung
AU  - Han BK
AD  - Department of Food and Biotechnology, Korea University, Sejong, Korea.
FAU - Heo, Wan
AU  - Heo W
AD  - Department of Food Science and Engineering, School of Convergence Bioscience and 
      Technology, Seowon University, Chungcheongbuk-do, Korea.
FAU - Yun, Beom Sik
AU  - Yun BS
AD  - R&D Center, Kwangdong Pharm Co., Ltd., Seoul, Korea.
FAU - Kim, Jin Soo
AU  - Kim JS
AD  - R&D Center, Kwangdong Pharm Co., Ltd., Seoul, Korea.
FAU - Koo, Young Tae
AU  - Koo YT
AD  - R&D Center, Kwangdong Pharm Co., Ltd., Seoul, Korea.
FAU - Hwang, Kyung-A
AU  - Hwang KA
AD  - Department of Agrofood Resources, National Institute of Agricultural Sciences, 
      Rural Development Administration, Jeollabuk-do, Korea.
FAU - Yoon, Jin A
AU  - Yoon JA
AD  - Department of Food and Nutrition, KC University, Seoul, Korea.
FAU - Kim, Young Jun
AU  - Kim YJ
AUID- ORCID: 0000-0003-1447-7857
AD  - Department of Food and Biotechnology, Korea University, Sejong, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Benzopyrans)
RN  - 0 (Butyrates)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - *Angelica
MH  - Animals
MH  - Astragalus propinquus
MH  - Benzopyrans
MH  - Butyrates
MH  - Mice
MH  - Plant Extracts
MH  - Quality of Life
OTO - NOTNLM
OT  - Angelica gigas Nakai
OT  - Astragalus membranaceus Bunge
OT  - Cervus elaphus L.
OT  - antifatigue
OT  - antioxidant
OT  - endurance capacity
EDAT- 2021/06/24 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/06/23 17:14
PHST- 2021/06/23 17:14 [entrez]
PHST- 2021/06/24 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
AID - 10.1089/jmf.2020.4743 [doi]
PST - ppublish
SO  - J Med Food. 2021 Jun;24(6):577-585. doi: 10.1089/jmf.2020.4743.