PMID- 34161168 OWN - NLM STAT- MEDLINE DCOM- 20220111 LR - 20220419 IS - 1557-7465 (Electronic) IS - 1079-9907 (Linking) VI - 41 IP - 6 DP - 2021 Jun TI - Long Noncoding RNA LINC00899/miR-944/ESR1 Axis Regulates Cervical Cancer Cell Proliferation, Migration, and Invasion. PG - 220-233 LID - 10.1089/jir.2021.0023 [doi] AB - Cervical cancer (CC) is a common malignancy in women. Long noncoding RNA LINC00899 plays a role in cancer, but its effects in CC are unknown. Our experiment aims to investigate the specific effects of LINC00899 in CC. LINC00899 was lowly expressed in CC tissues and cells, and overexpressed LINC0089 inhibited the viability, proliferation, migration, and invasion of CC cells, whereas silencing of LINC00899 had the opposite effect. There is a targeting relationship between LINC0089 and miR-944. It was found that miR-944 could competitively bind with LINC00899, and LINC00899 in turn, could downregulate expression of miR-944. Moreover, estrogen receptor 1 (ESR1) was the target gene of miR-944. Overexpressed miR-944 inhibited ESR1 expression, yet enhanced the migration and invasion of CC cells and promoted the expression levels of N-cadherin and Vimentin while inhibiting the expression of E-cadherin. However, overexpressed ESR1 reversed the effect of miR-944 overexpression on CC cells. LINC00899/miR-944/ESR1 axis regulates the proliferation, migration, and invasion of CC cells by regulating the expression levels of related proteins. FAU - Chen, Yu AU - Chen Y AD - Department of Gynecology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China. FAU - Gu, Yingjie AU - Gu Y AD - Department of Gynecology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China. FAU - Gu, Yanfang AU - Gu Y AD - Department of Gynecology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China. FAU - Wu, Jia AU - Wu J AUID- ORCID: 0000-0002-6177-4689 AD - Department of Gynecology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Interferon Cytokine Res JT - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research JID - 9507088 RN - 0 (ESR1 protein, human) RN - 0 (Estrogen Receptor alpha) RN - 0 (MIRN-944 microRNA, human) RN - 0 (MicroRNAs) RN - 0 (RNA, Long Noncoding) SB - IM EIN - J Interferon Cytokine Res. 2022 Apr;42(4):191. PMID: 35275748 MH - Cell Movement MH - Cell Proliferation MH - Estrogen Receptor alpha/genetics/*metabolism MH - Female MH - Humans MH - MicroRNAs/genetics/*metabolism MH - Middle Aged MH - RNA, Long Noncoding/genetics/*metabolism MH - Uterine Cervical Neoplasms/*metabolism/pathology OTO - NOTNLM OT - ESR1 OT - LINC00899 OT - cervical cancer OT - invasion OT - miR-944 OT - migration OT - proliferation EDAT- 2021/06/24 06:00 MHDA- 2022/01/12 06:00 CRDT- 2021/06/23 17:14 PHST- 2021/06/23 17:14 [entrez] PHST- 2021/06/24 06:00 [pubmed] PHST- 2022/01/12 06:00 [medline] AID - 10.1089/jir.2021.0023 [doi] PST - ppublish SO - J Interferon Cytokine Res. 2021 Jun;41(6):220-233. doi: 10.1089/jir.2021.0023.