PMID- 34162240
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220517
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 32
IP  - 3
DP  - 2022 May
TI  - How do intracranial tumors associated with visual pathways affect quadrant and 
      sectoral based optical coherence tomography measurements: The effect of 
      intracranial tumors on RNFL and GC-IPL thickness.
PG  - 1751-1759
LID - 10.1177/11206721211028035 [doi]
AB  - AIM: To investigate the quantitative sectoral and regional changes of retinal 
      nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) 
      thickness in different types of intracranial tumors associated with visual 
      pathways. METHODS: This comparative retrospective study included 58 eyes of 30 
      patients with intracranial tumors and the data of 62 eyes of 31 healthy subjects. 
      The RNFL and GCIPL thicknesses were analyzed using spectral-domain optical 
      coherence tomography (OCT). The tumors were classified into ones that affect 
      pre-geniculate and post-geniculate pathway. RESULTS: The mean RNFL thickness in 
      temporal quadrant was significantly thinner in eyes with intracranial tumors 
      affecting the pre-geniculate optic pathway compared to controls (p = 0.04). In 
      contrast, the mean superior quadrant RNFL thickness was significantly thicker in 
      eyes with brain tumors associated with post-geniculate optic pathway (p = 0.01). 
      The mean GC-IPL thicknesses of the inner ring superotemporal, superonasal, 
      inferotemporal and inferionasal sectors and outer ring superonasal and 
      inferonasal sectors were significantly thinner in eyes with intracranial tumors 
      affecting the pre-geniculate optic pathway compared to control eyes (p = 0.02, 
      p = 0.001, p = 0.02, p = 0.003, p = 0.008 and p = 0.03 respectively). CONCLUSION: 
      The results of this study showed that significant changes can be seen in the 
      different RNFL quadrants and GC-IPL sectors in eyes with intracranial tumors 
      affecting pre-geniculate or post-geniculate optic pathway. OCT is a very useful 
      imaging technique to quantify these structural changes which take place during 
      the neurodegeneration process of visual pathways in intracranial tumors.
FAU - Ozcan, Yasin
AU  - Ozcan Y
AUID- ORCID: 0000-0003-4536-1785
AD  - Ophthalmology Department, Yeditepe University Medical Faculty, Yeditepe 
      University Speciality Hospital, Istanbul, Turkey.
FAU - Talipinar, Sinan
AU  - Talipinar S
AD  - Ophthalmology Department, Yeditepe University Medical Faculty, Yeditepe Eye 
      Center, Istanbul, Turkey.
FAU - Kayiran, Alp
AU  - Kayiran A
AD  - Ophthalmology Department, Yeditepe University Medical Faculty, Yeditepe Eye 
      Center, Istanbul, Turkey.
FAU - Ture, Ugur
AU  - Ture U
AD  - Department of Neurosurgeon, Yeditepe University Medical Faculty, Yeditepe 
      University Speciality Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210624
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - *Brain Neoplasms/diagnostic imaging
MH  - Humans
MH  - Nerve Fibers/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence/methods
MH  - Visual Pathways/pathology
OTO - NOTNLM
OT  - Neuro-imaging
OT  - diagnostic techniques
OT  - neuro-ophthalmic disease
OT  - optic neuropathy
OT  - tumors/neoplasms
EDAT- 2021/06/25 06:00
MHDA- 2022/05/18 06:00
CRDT- 2021/06/24 05:27
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2021/06/24 05:27 [entrez]
AID - 10.1177/11206721211028035 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2022 May;32(3):1751-1759. doi: 10.1177/11206721211028035. Epub 
      2021 Jun 24.