PMID- 34163179
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 1178-6965 (Print)
IS  - 1178-6965 (Electronic)
IS  - 1178-6965 (Linking)
VI  - 14
DP  - 2021
TI  - Assessment of Airway Remodeling Using Endobronchial Ultrasound in Asthma-COPD 
      Overlap.
PG  - 663-674
LID - 10.2147/JAA.S306421 [doi]
AB  - PURPOSE: The aim of this study was to evaluate the structural changes of the 
      airways using the endobronchial ultrasound (EBUS) in ACO patients compared to 
      severe asthma and COPD patients. PATIENTS AND METHODS: The study included 17 
      patients with ACO, 17 patients with COPD and 33 patients with severe asthma. 
      Detailed clinical data were obtained from all participants. Basic laboratory 
      tests were performed, including measurement of eosinophil counts in blood and 
      serum immunoglobulin E (IgE) concentrations. All patients underwent spirometry 
      and bronchoscopy with EBUS (a 20‑MHz ultrasound probe) to measure the total 
      thicknesses of the bronchial walls and their particular layers in segmental 
      bronchi of the right lower lobe. EBUS allows to distinguish five layers of the 
      bronchial wall. Layer 1 (L(1)) and layer 2 (L(2)) were analyzed separately, while 
      the outer layers (layers 3-5 [L(3-5)]) that correspond to cartilage were assessed 
      together. RESULTS: In patients with ACO the thicknesses of the L(1) and L(2) 
      layers, which are mainly responsible for remodeling, were significantly greater 
      than in patients with COPD and significantly smaller than in patients with severe 
      asthma (median L(1)= 0.17 mm vs 0.16 mm vs 0.18 mm, p<0.001; median L(2)= 0.18 mm 
      vs 0.17 mm vs 0.20 mm, p<0.001, respectively). The thicknesses of the total 
      bronchial walls (L(1)+L(2)+L(3-5)) and L(3-5) were significantly smaller in ACO 
      and COPD patients compared to asthma patients (median L(1)+L(2)+L(3-5)= 1.2 mm vs 
      1.14 mm vs 1.31 mm, p<0.001; median L(3-5)= 0.85 mm vs, 0.81 mm vs 0.92 mm, 
      p=0.001, respectively). CONCLUSION: The process of structural changes in the 
      airways assessed by EBUS is more advanced in individuals with ACO compared to 
      patients with COPD, and less pronounced compared to patients with severe asthma. 
      It seems that EBUS may provide useful information about differences in airway 
      remodeling between ACO, COPD and severe asthma.
CI  - (c) 2021 Gorka et al.
FAU - Gorka, Karolina
AU  - Gorka K
AUID- ORCID: 0000-0002-6404-7233
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - 2nd Department of Internal Medicine, Jagiellonian University Medical College, 
      Krakow, Poland.
FAU - Gross-Sondej, Iwona
AU  - Gross-Sondej I
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - 2nd Department of Internal Medicine, Jagiellonian University Medical College, 
      Krakow, Poland.
FAU - Gorka, Jacek
AU  - Gorka J
AD  - Centre for Intensive Care and Perioperative Medicine, Jagiellonian University 
      Medical College, Krakow, Poland.
FAU - Stachura, Tomasz
AU  - Stachura T
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - 2nd Department of Internal Medicine, Jagiellonian University Medical College, 
      Krakow, Poland.
FAU - Polok, Kamil
AU  - Polok K
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - Centre for Intensive Care and Perioperative Medicine, Jagiellonian University 
      Medical College, Krakow, Poland.
FAU - Celejewska-Wojcik, Natalia
AU  - Celejewska-Wojcik N
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - 2nd Department of Internal Medicine, Jagiellonian University Medical College, 
      Krakow, Poland.
FAU - Mikrut, Slawomir
AU  - Mikrut S
AUID- ORCID: 0000-0002-4389-7562
AD  - Faculty of Mining Surveying and Environmental Engineering, AGH University of 
      Science and Technology, Krakow, Poland.
FAU - Andrychiewicz, Anna
AU  - Andrychiewicz A
AD  - Department of Endoscopy, University Hospital, Krakow, Poland.
FAU - Sladek, Krzysztof
AU  - Sladek K
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - 2nd Department of Internal Medicine, Jagiellonian University Medical College, 
      Krakow, Poland.
FAU - Soja, Jerzy
AU  - Soja J
AUID- ORCID: 0000-0003-4562-6675
AD  - Department of Pulmonology and Allergology, University Hospital, Krakow, Poland.
AD  - 2nd Department of Internal Medicine, Jagiellonian University Medical College, 
      Krakow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210614
PL  - New Zealand
TA  - J Asthma Allergy
JT  - Journal of asthma and allergy
JID - 101543450
PMC - PMC8214023
OTO - NOTNLM
OT  - airway remodeling
OT  - asthma-COPD overlap
OT  - bronchial wall layers
OT  - endobronchial ultrasound
OT  - total bronchial wall
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/06/25 06:00
MHDA- 2021/06/25 06:01
PMCR- 2021/06/14
CRDT- 2021/06/24 06:30
PHST- 2021/02/12 00:00 [received]
PHST- 2021/04/30 00:00 [accepted]
PHST- 2021/06/24 06:30 [entrez]
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2021/06/25 06:01 [medline]
PHST- 2021/06/14 00:00 [pmc-release]
AID - 306421 [pii]
AID - 10.2147/JAA.S306421 [doi]
PST - epublish
SO  - J Asthma Allergy. 2021 Jun 14;14:663-674. doi: 10.2147/JAA.S306421. eCollection 
      2021.