PMID- 34163222
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 14
DP  - 2021
TI  - Release Profile of Cardiac Troponin T and Risk Factors of Postoperative 
      Myocardial Injury in Patients Undergoing CABG.
PG  - 2541-2551
LID - 10.2147/IJGM.S315691 [doi]
AB  - BACKGROUND: Cardiac troponin T (cTnT) is currently one of the important 
      indicators for clinical diagnosis of myocardial injury, which is inevitable in 
      cardiac surgery, especially coronary artery bypass grafting (CABG). Describing 
      the release profile of cTnT and finding out the risk factors of postoperative 
      myocardial injury (PMI) are of great significance. The purposes of this study are 
      to explore the release profile of cTnT in patients undergoing CABG and to search 
      for independent risk factors of PMI. METHODS: In this retrospective study, 
      clinical data of CABG patients were collected. The cTnT was measured at 24 hours 
      before and 6, 12, 24, 48, 72, 96 and 120 hours after operation separately. The 
      release profiles and peak time of cTnT in total cohort and sub-cohorts were 
      observed. Independent risk factors of PMI were explored via univariate and 
      multivariate logistic regression analyses. RESULTS: In total, 2084 patients were 
      enrolled, including 998 patients in a cTnT group and 1086 patients in a 
      high-sensitive cTnT (hs-cTnT) group. PMI was recognized in 797 patients. In both 
      groups, cTnT showed a trend of rising first and then falling within 120 hours 
      after operation. The peak cTnT appeared within 12-24 hours after operation, while 
      the peak hs-cTnT occurred mostly within 24-48 hours after operation. Univariate 
      logistic analysis showed that body mass index (BMI), New York Heart Association 
      (NYHA) classification, coronary artery disease (CAD) classification, 
      cerebrovascular disease, left ventricular ejection fraction, number of diseased 
      vessels, valvular disease, intra-aortic balloon pump (IABP) implantation, chronic 
      obstructive pulmonary disease, pulmonary hypertension, previous percutaneous 
      coronary intervention (PCI), BMI, bypass graft number, cardiopulmonary bypass, 
      and preoperative cTnT were related risk factors. Multivariate logistic regression 
      analysis showed that NYHA classification, CAD classification, valvular disease, 
      IABP implantation, pulmonary hypertension, previous PCI, bypass graft number, 
      cardiopulmonary bypass, and preoperative cTnT were independent risk factors of 
      PMI. CONCLUSION: NYHA classification, CAD classification, valvular disease, IABP 
      implantation, pulmonary hypertension, previous PCI, bypass graft number, 
      cardiopulmonary bypass, and preoperative cTnT are independent risk factors of PMI 
      in patients undergoing CABG.
CI  - (c) 2021 Gu et al.
FAU - Gu, Yuying
AU  - Gu Y
AD  - Department of Cardiology, Shanghai East Hospital, Tongji University School of 
      Medicine, Shanghai, People's Republic of China.
FAU - Shan, Lingtong
AU  - Shan L
AUID- ORCID: 0000-0002-3041-7515
AD  - Department of Thoracic Surgery, Sheyang County People's Hospital, Yancheng, 
      Jiangsu, People's Republic of China.
FAU - Liu, Ban
AU  - Liu B
AD  - Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, Shanghai, People's Republic of China.
FAU - Lv, Mengwei
AU  - Lv M
AD  - Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, People's Republic of China.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, People's Republic of China.
FAU - Yan, Tao
AU  - Yan T
AD  - Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, 
      Shanghai, People's Republic of China.
FAU - Shi, Yu
AU  - Shi Y
AD  - Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, People's Republic of China.
FAU - Chen, Jiapeng
AU  - Chen J
AD  - Xinglin College, Nantong University, Nantong, Jiangsu, People's Republic of 
      China.
FAU - Li, Zhi
AU  - Li Z
AUID- ORCID: 0000-0003-2674-8255
AD  - Department of Cardiovascular Surgery, Jiangsu Province Hospital, The First 
      Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, People's 
      Republic of China.
FAU - Zhang, Yangyang
AU  - Zhang Y
AUID- ORCID: 0000-0003-3754-8291
AD  - Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210615
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC8214547
OTO - NOTNLM
OT  - cardiac troponin T
OT  - coronary artery bypass grafting
OT  - myocardial injury
COIS- The authors declare that they have no competing interests.
EDAT- 2021/06/25 06:00
MHDA- 2021/06/25 06:01
PMCR- 2021/06/15
CRDT- 2021/06/24 06:30
PHST- 2021/04/14 00:00 [received]
PHST- 2021/05/27 00:00 [accepted]
PHST- 2021/06/24 06:30 [entrez]
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2021/06/25 06:01 [medline]
PHST- 2021/06/15 00:00 [pmc-release]
AID - 315691 [pii]
AID - 10.2147/IJGM.S315691 [doi]
PST - epublish
SO  - Int J Gen Med. 2021 Jun 15;14:2541-2551. doi: 10.2147/IJGM.S315691. eCollection 
      2021.