PMID- 34164252
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210625
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 6
DP  - 2021 Jun 19
TI  - Herpes Simplex Virus-2 Meningitis Masquerading as Pseudotumor Cerebri.
PG  - e15764
LID - 10.7759/cureus.15764 [doi]
LID - e15764
AB  - We report a case of a 27-year-old obese female presenting with headache, blurry 
      and double vision. She was found to have bilateral papilledema by an 
      ophthalmologist and sent to the emergency department (ED). Cerebrospinal fluid 
      (CSF) analysis showed elevated opening pressure and lymphocytic pleocytosis. 
      Symptoms improved significantly after lumbar puncture (LP). Subsequently, 
      polymerase chain reaction (PCR) for herpes simplex virus-2 (HSV-2) came back 
      positive. This case represents an unusual presentation of HSV-2 meningitis, where 
      the clinical picture was suggestive of pseudotumor cerebri or idiopathic 
      intracranial hypertension (IIH), but CSF analysis revealed HSV-2. Papilledema and 
      elevated intracranial pressure has not previously been described in association 
      with HSV-2. Therefore, patients presenting with typical signs and meeting all 
      diagnostic criteria for IIH in the presence of CSF pleocytosis may represent a 
      distinct group of viral-induced intracranial hypertension. In these cases, an 
      investigation of viral etiologies should be conducted.
CI  - Copyright (c) 2021, Sherchan et al.
FAU - Sherchan, Robin
AU  - Sherchan R
AD  - Internal Medicine, Northwestern Medicine McHenry Hospital, Rosalind Franklin 
      University of Medicine and Science, McHenry, USA.
FAU - Shrestha, Jishna
AU  - Shrestha J
AD  - Internal Medicine, Northwestern Medicine McHenry Hospital, Rosalind Franklin 
      University of Medicine and Science, McHenry, USA.
FAU - Omotosho, Yetunde B
AU  - Omotosho YB
AD  - Internal Medicine, Northwestern Medicine McHenry Hospital, Rosalind Franklin 
      University of Medicine and Science, McHenry, USA.
FAU - Dyatlova, Nataliia
AU  - Dyatlova N
AD  - Internal Medicine, Northwestern Medicine McHenry Hospital, Rosalind Franklin 
      University of Medicine and Science, McHenry, USA.
FAU - Nepomuceno, Jenie S
AU  - Nepomuceno JS
AD  - Internal Medicine, Northwestern Medicine McHenry Hospital, Metro Infectious 
      Disease Consultants, McHenry, USA.
LA  - eng
PT  - Case Reports
DEP - 20210619
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8214452
OTO - NOTNLM
OT  - aseptic meningitis
OT  - elevated intracranial pressure
OT  - herpes simplex virus
OT  - hsv meningitis
OT  - hsv-2
OT  - idiopathic intracranial hypertension
OT  - intracranial hypertension secondary to viral infection
OT  - papilledema
OT  - pseudotumor cerebri
OT  - viral meningitis causing elevated icp
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/06/25 06:00
MHDA- 2021/06/25 06:01
PMCR- 2021/06/19
CRDT- 2021/06/24 06:38
PHST- 2021/06/24 06:38 [entrez]
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2021/06/25 06:01 [medline]
PHST- 2021/06/19 00:00 [pmc-release]
AID - 10.7759/cureus.15764 [doi]
PST - epublish
SO  - Cureus. 2021 Jun 19;13(6):e15764. doi: 10.7759/cureus.15764.