PMID- 34165048
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 62
IP  - 9
DP  - 2021 Sep
TI  - Molecular characterization of Burkitt lymphoma in the breast or ovary.
PG  - 2120-2129
LID - 10.1080/10428194.2021.1907374 [doi]
AB  - Breast and ovary have been described as rare but typical sites of presentation of 
      Burkitt lymphoma (BL) in females, particularly after puberty. We revised a 
      historic series of 44 lymphomas of the breast or the ovary in women diagnosed 
      between 1973 and 2014 as BL. Fluorescence in situ hybridization (FISH) was 
      applied to all, and array-based copy number analysis as well as expression 
      profiling to a subset of those cases. Of the 42 cases evaluable for FISH, 19 
      cases showed an IG-MYC translocation but only 9 of those fulfilled the criteria 
      of the current WHO classification for the diagnosis of BL. Those nine cases 
      resembled BL of other sites with regard to molecular features. Our findings along 
      with literature data suggest that breast and ovarian BL (1) seem to be rarer than 
      hitherto assumed, (2) share typical molecular features with other BL, and (3) 
      predominantly affect women in the fertile age.
FAU - Elgaafary, Shaymaa
AU  - Elgaafary S
AUID- ORCID: 0000-0002-2846-6000
AD  - Institute of Human Genetics, Ulm University and Ulm University Medical Center, 
      Ulm, Germany.
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
AD  - Department of Human Cytogenetics, National Research centre, Division of Human 
      Genetics and Genome Research, Cairo, Egypt.
FAU - Lopez, Cristina
AU  - Lopez C
AUID- ORCID: 0000-0001-6644-1659
AD  - Institute of Human Genetics, Ulm University and Ulm University Medical Center, 
      Ulm, Germany.
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Nagel, Inga
AU  - Nagel I
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
AD  - Institute of Experimental and Clinical Pharmacology, Christian-Albrechts 
      University Kiel and University, Hospital Schleswig-Holstein, Campus Kiel, Kiel, 
      Germany.
FAU - Vater, Inga
AU  - Vater I
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Bens, Susanne
AU  - Bens S
AD  - Institute of Human Genetics, Ulm University and Ulm University Medical Center, 
      Ulm, Germany.
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Szczepanowski, Monika
AU  - Szczepanowski M
AD  - Hematopathology Section and Lymph Node Registry, Christian-Albrechts University 
      Kiel and University Hospital, Schleswig-Holstein, Campus Kiel, Kiel, Germany.
AD  - Clinic of Internal Medicine II, Laboratory of Hematology, University Hospital 
      Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Aukema, Sietse M
AU  - Aukema SM
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
AD  - Hematopathology Section and Lymph Node Registry, Christian-Albrechts University 
      Kiel and University Hospital, Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Wagener, Rabea
AU  - Wagener R
AD  - Institute of Human Genetics, Ulm University and Ulm University Medical Center, 
      Ulm, Germany.
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Hopp, Lydia
AU  - Hopp L
AD  - Institute of Medical Informatics, Statistics and Epidemiology, University of 
      Leipzig, Leipzig, Germany.
FAU - Binder, Hans
AU  - Binder H
AD  - Institute of Medical Informatics, Statistics and Epidemiology, University of 
      Leipzig, Leipzig, Germany.
FAU - de Leval, Laurence
AU  - de Leval L
AD  - Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Klapper, Wolfram
AU  - Klapper W
AD  - Hematopathology Section and Lymph Node Registry, Christian-Albrechts University 
      Kiel and University Hospital, Schleswig-Holstein, Campus Kiel, Kiel, Germany.
FAU - Siebert, Reiner
AU  - Siebert R
AD  - Institute of Human Genetics, Ulm University and Ulm University Medical Center, 
      Ulm, Germany.
AD  - Institute of Human Genetics, Christian-Albrechts University Kiel and University 
      Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210624
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - *Burkitt Lymphoma/diagnosis/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lymphoma/genetics
MH  - *Lymphoma, Large B-Cell, Diffuse/genetics
MH  - Ovary
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - Burkitt
OT  - MYC
OT  - Ovary
OT  - breast
OT  - lymphoma
EDAT- 2021/06/25 06:00
MHDA- 2023/02/25 06:00
CRDT- 2021/06/24 08:48
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2021/06/24 08:48 [entrez]
AID - 10.1080/10428194.2021.1907374 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2021 Sep;62(9):2120-2129. doi: 10.1080/10428194.2021.1907374. Epub 
      2021 Jun 24.